Safety · Adverse events · continued

Follow-up: Signs of dehydration worth acting on posts 31–40

Safety › Adverse events delayed gastric emptying pancreatitis hypoglycaemia

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

KStephanopoulosTL3Regular20 Jul 2026#31

taper_shift, post #18: post #17 answers the question as asked. The question underneath it is different. Acute kidney injury: rare but reported. Symptoms (decreased urine output, creatinine elevation) warrant urgent evaluation. Severe dehydration during weight loss is a risk factor. Go to post

Two things before anyone answers the substance.

First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound.

27 likes in reply to #18 8d

ar.kravchenkoTL2 Moderator20 Jul 2026#32

a.asante, post #11: I read post #9 twice before replying, because I had assumed the opposite. Medullary thyroid carcinoma is the reason these compounds are contraindicated in people with personal or family history of MTC or multiple endocrine neoplasia type 2. Rodent toxicology showed a signal; human evidence of causation is absent but caution is… Go to post

post #31 is right about the mechanism and I think understates the practical bit.

Pancreatitis is a genuine serious adverse event to know: severe epigastric pain, back pain, elevated lipase (≥3× upper limit of normal). If this constellation appears, stopping the drug and seeking urgent evaluation is appropriate.

13 likes in reply to #11 7d

endpoint_marginTL2Member21 Jul 2026#33

I read post #31 twice before replying, because I had assumed the opposite.

Severe gastrointestinal events: persistent vomiting, abdominal pain out of proportion, or signs of bowel obstruction warrant urgent evaluation. Mild nausea and constipation are ordinary; severe versions are not.

2 likes 7d

s.vogelTL2 Moderator22 Jul 2026#34

Acute kidney injury: rare but reported. Symptoms (decreased urine output, creatinine elevation) warrant urgent evaluation. Severe dehydration during weight loss is a risk factor.

0 likes 6d

citation_indexTL223 Jul 2026#35

Collapsed as off-topic by two members at trust level 3 or above

How to document: date, exact symptom or event, severity, duration, outcome, any medical attention sought. Detailed documentation is far more useful than a vague report.

p.fontaineTL2 Moderator24 Jul 2026#36

Where to report: in many countries there is a pharmacovigilance system where adverse events can be reported. FDA MedWatch in the US, Yellow Card in UK, EudraVigilance in EU.

8 likes 4d

footnote_entryTL3Regular24 Jul 2026 · edited#37

Coming back to post #35, because the follow-up matters more than the original answer.

Medullary thyroid carcinoma is the reason these compounds are contraindicated in people with personal or family history of MTC or multiple endocrine neoplasia type 2. Rodent toxicology showed a signal; human evidence of causation is absent but caution is appropriate.

0 likes 3d

m.oyelaranTL2 Moderator25 Jul 2026#38

Picking up post #35: that is the part I would want checked first.

How to document: date, exact symptom or event, severity, duration, outcome, any medical attention sought. Detailed documentation is far more useful than a vague report.

0 likes 3d

cannula_traceTL3Regular26 Jul 2026#39

0 likes 2d

g.amankwahTL2 Moderator27 Jul 2026 · edited#40

crossover_entry, post #6: On post #2 — agreed on the reasoning, with one qualification. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had been repeating something I had not checked carefully enough. Go to post

Acute kidney injury: rare but reported. Symptoms (decreased urine output, creatinine elevation) warrant urgent evaluation. Severe dehydration during weight loss is a risk factor.

26 likes in reply to #6 1d

This topic was referenced in

Severe abdominal pain: why this is not a forum questionSafety › Adverse events · 2 replies
Signs of dehydration worth acting onSafety › Adverse events · 38 replies
Persistent vomiting and the threshold for seeking helpSafety › Adverse events · 88 replies

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