Incretin analogue dose equivalence
Where a dose sits on its own ladder, and which step of another agent sits at a comparable place. Comparative, not interchangeable.
People switching between agents want to know "what is my equivalent dose". There is no clean answer, because these are different molecules at different receptors with different trial ladders, and no head-to-head study was designed to establish equivalence at every step.
What can honestly be said is where a dose sits as a proportion of its own approved ladder, and which step of another ladder sits at a comparable position. That is what this does. It is a conversation-starter with a prescriber, not a conversion factor.
| Agent | Ladder (mg) | Your position |
|---|
What this cannot tell you
Not how you will respond, not how you will tolerate it, and not what to switch to. Response varies widely between individuals at the same dose, and the tolerability curves differ between agents — the GI adverse events in both programmes were dose-related but not identically so.
SURMOUNT-5 compared tirzepatide against semaglutide directly at their respective maintenance doses, which is the closest thing to a real comparison that exists. It compared endpoints, not equivalence.