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On the live site this tab tracks what you have not read. In this static rendering it shows every topic with activity in the last 45 days, which is the closest honest equivalent — we would rather explain the difference than pretend a static page knows your reading history.

414 topics · page 1 of 14

Topic	Participants	Replies	Views	Activity
I joined for one answer and stayed for a year — what changed my mind Start Here › Welcome guidelines onboarding trust levels Posting this under the heading it deserves: I joined for one answer and stayed for a year — what changed my mind Everything below is what sits behind that. Question in the title. Context below, and I have…	+96	114	17k	just now
What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still hold? Compounds › Retatrutide randomised trial effect size TRIUMPH programme retatrutide Solved Asking directly, because I could not find a straight answer: What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still hold? Session topic: STEP 2 ( Lancet , 2021). Please read…	+43	47	5.5k	just now
Rotating between abdomen, thigh and upper arm: absorption differences — one year on Practice › Administration injection site reaction needle gauge & length aseptic technique injection site rotation Rotating between abdomen, thigh and upper arm: absorption differences — one year on — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still…	+82	102	24k	just now
Journal club: indirect comparison between two programmes, defended and attacked Evidence › Journal club journal club randomised trial number needed to treat risk of bias Journal club: indirect comparison between two programmes, defended and attacked Writing it up because I had to work it out twice and would rather nobody else did. Comparing SUSTAIN 6 ( N Engl J Med , 2016)…	+122	131	5.2k	just now
eGFR fluctuation and the creatinine denominator problem — the long version Clinical › Bloodwork thyroid function eGFR & renal function liver enzymes lipase & amylase Under review eGFR fluctuation and the creatinine denominator problem — the long version — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The…	+43	47	17k	just now
Receptor desensitisation as a tolerance hypothesis, and its weak evidence Pharmacology › Receptor biology tirzepatide retatrutide amylin analogues long read Under review Receptor desensitisation as a tolerance hypothesis, and its weak evidence — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a…	+52	57	25k	just now
Reading a syringe in poor light, and how to avoid needing to Devices › Syringes & needles syringe units dead volume needle gauge & length worked example Solved Reading a syringe in poor light, and how to avoid needing to Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen…		2	22k	just now
Semaglutide formulation: what is in the licensed product besides the peptide Compounds › Semaglutide SELECT trial type 2 diabetes semaglutide Semaglutide formulation: what is in the licensed product besides the peptide — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURMOUNT-1 ( N…	+29	35	4.4k	1h
What consumer-accessible tests can and cannot determine Analytics › Home & field testing documentation quality ELISA third-party testing What consumer-accessible tests can and cannot determine — that is the question, and I have not found it answered plainly anywhere I have looked. Posting the method first, because I know what the first three…		2	17k	1h
Language barriers in accessing a prescription abroad Access › International personal import telehealth EMA Solved Language barriers in accessing a prescription abroad Writing it up because I had to work it out twice and would rather nobody else did. Documenting an access outcome, dated, because everything in this…		2	22k	1h
Cleaning a self-reported dataset and what you throw away — what changed since Data & Tools › Datasets observational data site feedback data table confounding Solved Posting this under the heading it deserves: Cleaning a self-reported dataset and what you throw away — what changed since Everything below is what sits behind that. Posting the method first, because I know…		2	2k	1h
Where to report an adverse event officially, by region Safety › Adverse events pancreatitis gallbladder vomiting hypoglycaemia Solved Where to report an adverse event officially, by region Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…		2	27k	1h
Revisiting: The best-written scientific paper you have read Lounge › Off topic beginner friendly long read Posting this under the heading it deserves: Revisiting: The best-written scientific paper you have read Everything below is what sits behind that. Lower-stakes topic, but the sourcing rule still applies if…	+102	121	21k	1h
GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Compounds › Secretagogues & GH axis CJC-1295 observational data ipamorelin needs a source Solved On the subject in the title: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Working notes rather than a conclusion. I have seen STEP 2 ( Lancet , 2021) cited in support of…	+47	53	6.9k	2h
A widely repeated interaction claim that turns out to be unsupported — what changed since Practice › Interactions insulin hypoglycaemia metformin needs a source Solved A widely repeated interaction claim that turns out to be unsupported — what changed since Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on…	+89	94	5.9k	2h
Journal club: LEADER as the historical anchor Evidence › Journal club estimand number needed to treat journal club effect size Pinned Journal club: LEADER as the historical anchor Writing it up because I had to work it out twice and would rather nobody else did. Comparing STEP 1 ( N Engl J Med , 2021) with SURMOUNT-4 ( JAMA , 2024) and…	+103	110	8.1k	2h
Reference intervals: how they are constructed and why one in twenty flags — does this still hold? Clinical › Bloodwork thyroid function liver enzymes lipid panel HbA1c Solved Asking directly, because I could not find a straight answer: Reference intervals: how they are constructed and why one in twenty flags — does this still hold? General question, not a request for advice about…	+18	22	281	2h
Request: a per-category review queue Meta › Feature requests site feedback translation wiki post Request: a per-category review queue Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the documentation commons. The topic in question…	+125	136	13k	2h
Leak-back after withdrawal and whether you lost a meaningful dose Practice › Administration missed dose injection site reaction injection site rotation aseptic technique Posting this under the heading it deserves: Leak-back after withdrawal and whether you lost a meaningful dose Everything below is what sits behind that. Reporting something rather than asking about it, in…		2	3k	3h
Coming back to: Batch date after test date, and other internal inconsistencies Analytics › COA interpretation reference standards amino acid analysis documentation quality certificate of analysis On the subject in the title: Batch date after test date, and other internal inconsistencies Working notes rather than a conclusion. I would like to understand what this number means before I repeat it…	+21	27	420	3h
Revisiting: Liver enzymes drifting down and what that usually means Clinical › Bloodwork thyroid function eGFR & renal function liver enzymes lipase & amylase On the subject in the title: Revisiting: Liver enzymes drifting down and what that usually means Working notes rather than a conclusion. General question, not a request for advice about my own care — I know…	+55	61	39k	3h
What to bring: records that a clinician can actually use — a second dataset Clinical › Prescriber conversations telehealth beginner friendly prior authorisation What to bring: records that a clinician can actually use — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about a population rather than…	+80	86	5.6k	3h
Prescription portability between countries Access › International personal import MHRA telehealth EMA Wiki Prescription portability between countries — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines the…	+104	114	6.1k	3h
Injection timing and sleep disruption Wellbeing › Sleep fatigue heart rate obstructive sleep apnoea Solved Posting this under the heading it deserves: Injection timing and sleep disruption Everything below is what sits behind that. General question, not a request for advice about my own care — I know the…		3	39k	3h
Request: tag synonyms surfaced in search Meta › Feature requests wiki post translation site feedback Solved On the subject in the title: Request: tag synonyms surfaced in search Working notes rather than a conclusion. Process question about how this site works. I have read the guidelines and the trust-level page…	+23	27	38k	3h
About the Announcements category Meta › Announcements guidelines trust levels moderation Pinned Wiki Staff announcements, policy changes, and scheduled maintenance. Read-only except for questions. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…	+3	7	8.7k	4h
Reading order for a first week here, and what to skip until later — what changed since Start Here › Welcome onboarding guidelines beginner friendly trust levels Reading order for a first week here, and what to skip until later — what changed since Writing it up because I had to work it out twice and would rather nobody else did. I want to check my reasoning rather…	+89	93	28k	4h
How to ask a question when you cannot say why you are asking it Start Here › How to Ask beginner friendly site feedback worked example onboarding Solved Asking directly, because I could not find a straight answer: How to ask a question when you cannot say why you are asking it Question in the title. Context below, and I have tried to include the things people…	+49	53	36k	4h
How to ask about something you suspect is a bad idea — a second dataset Start Here › How to Ask beginner friendly onboarding site feedback Solved How to ask about something you suspect is a bad idea — a second dataset — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I…		2	3.3k	4h
Reading a rodent study on a secretagogue without over-extrapolating — the long version Compounds › Secretagogues & GH axis observational data tesamorelin ipamorelin needs a source Reading a rodent study on a secretagogue without over-extrapolating — the long version — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support…	+59	66	30k	4h

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