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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 1 of 40

Topic	Participants	Replies	Views	Activity
Distinguishing a red flag from an inconvenience — a second dataset Sourcing › Red flags moderation documentation quality disputed On the subject in the title: Distinguishing a red flag from an inconvenience — a second dataset Working notes rather than a conclusion. A logistics question, since the answers here are usually better than…	+8	12	9.6k	1d
PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one Compounds › Oral incretins PIONEER programme SOUL trial randomised trial orforglipron Solved PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one — setting out what I have, and where I think it stops being reliable. Session topic: FLOW ( N Engl J Med , 2024). Please…	+25	29	22k	1d
How to ask about something you suspect is a bad idea — a second dataset Start Here › How to Ask beginner friendly onboarding site feedback Solved How to ask about something you suspect is a bad idea — a second dataset — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I…		2	3.3k	4h
Coming back to: Preparing for an appointment: one page, three questions Clinical › Prescriber conversations telehealth beginner friendly type 2 diabetes prior authorisation Preparing for an appointment: one page, three questions — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I know the…	+51	56	1.4k	2d
Why the Start Here categories exist, and what they are not for Start Here › Welcome guidelines trust levels onboarding beginner friendly Solved Why the Start Here categories exist, and what they are not for — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I have tried…	+40	44	32k	1d
A structured critique template this community uses Evidence › Study critique observational data effect size risk of bias A structured critique template this community uses — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with SURPASS-4 ( Lancet , 2021) and finding the…		2	18k	1d
Irish differences from the UK position — what changed since Regional › UK & Ireland personal import cost per milligram NHS Irish differences from the UK position — what changed since — setting out what I have, and where I think it stops being reliable. Documenting an access outcome, dated, because everything in this category…	+8	12	782	1d
What to bring: records that a clinician can actually use Clinical › Prescriber conversations beginner friendly type 2 diabetes prior authorisation Solved Asking directly, because I could not find a straight answer: What to bring: records that a clinician can actually use Asking about a population rather than about a person. The published trials in this class…	+15	19	6.4k	1d
eGFR fluctuation and the creatinine denominator problem — the long version Clinical › Bloodwork thyroid function eGFR & renal function liver enzymes lipase & amylase Under review eGFR fluctuation and the creatinine denominator problem — the long version — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The…	+43	47	17k	just now
What a statistical analysis plan adds that the paper does not Evidence › Trials open label discontinuation & dropout randomised trial surrogate endpoints Solved What a statistical analysis plan adds that the paper does not — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SCALE ( N Engl J Med , 2015) cited in support…		2	6.6k	10h
About the Reconstitution category Practice › Reconstitution reconstitution concentration maths syringe units Pinned Wiki Diluent choice, volumes, resulting concentrations, worked examples, and the errors we see most often. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+1	5	15k	16h
Priming a pen and whether the primed volume is wasted Devices › Pens & autoinjectors storage missed dose dead volume Solved Wiki Priming a pen and whether the primed volume is wasted Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+19	23	1.3k	2d
Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Compounds › Retatrutide retatrutide randomised trial effect size preprint Solved Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med ,…	+10	14	8.4k	16h
Tirzepatide storage and stability: what is published versus what is assumed Compounds › Tirzepatide SURPASS programme randomised trial SURMOUNT programme effect size On the subject in the title: Tirzepatide storage and stability: what is published versus what is assumed Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read…	+17	21	17k	12d
Transit times by route, from a logged dataset Sourcing › Logistics packaging customs shipping Solved Transit times by route, from a logged dataset Writing it up because I had to work it out twice and would rather nobody else did. A logistics question, since the answers here are usually better than anywhere…	+34	38	3.6k	18h
What the GIP component of tirzepatide is thought to contribute, and how confident we can be Compounds › Tirzepatide tirzepatide SURPASS programme SURMOUNT programme effect size Solved What the GIP component of tirzepatide is thought to contribute, and how confident we can be I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing STEP 1 ( N Engl…	+16	20	23k	19h
Osteoarthritis and mechanical versus metabolic improvement — one year on Clinical › Comorbidities chronic kidney disease MASH / hepatic steatosis obstructive sleep apnoea blood pressure Under review On the subject in the title: Osteoarthritis and mechanical versus metabolic improvement — one year on Working notes rather than a conclusion. General question, not a request for advice about my own care — I…	+52	56	8.1k	15d
Seven-day rolling means and why weekly readings mislead Outcomes › Progress reports data table DXA effect size long read Seven-day rolling means and why weekly readings mislead Writing it up because I had to work it out twice and would rather nobody else did. Maintenance rather than loss, which is the part of this that almost…	+109	125	42k	10h
Which categories are strict and which are relaxed, honestly Start Here › Welcome onboarding beginner friendly guidelines trust levels Solved Which categories are strict and which are relaxed, honestly I have a specific reason for asking rather than idle curiosity, and the context is below. I want to check my reasoning rather than get a conclusion.…	+47	53	1.8k	2d
Impurity thresholds: where the common numbers come from Analytics › Impurities & related substances water content data table forced degradation counter-ion content Impurity thresholds: where the common numbers come from — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate in…	+11	15	825	2d
Follow-up: How compounding permissions changed when supply normalised Sourcing › Regulatory MHRA personal import research use only How compounding permissions changed when supply normalised I have a specific reason for asking rather than idle curiosity, and the context is below. Structured report rather than an opinion, following the…	+72	77	1.5k	1d
What a certificate commits its issuer to Analytics › COA interpretation reference standards batch & lot numbers amino acid analysis The question in the title: What a certificate commits its issuer to I will give what I have already checked below so nobody repeats it. A documentation question rather than an analytical one. I have a…	+101	116	26k	19h
About the Independent verification category Sourcing › Independent verification Janoshik Analytical Medutest PeptideMeter Pinned Wiki Janoshik, Medutest, PeptideMeter and VendorInvestigate results, how to submit a sample, and how to read what comes back. This post is a community wiki: any member at trust level 3 or above can edit it, and…	+1	5	5.8k	23h
eGFR fluctuation and the creatinine denominator problem Clinical › Bloodwork eGFR & renal function liver enzymes lipid panel On the subject in the title: eGFR fluctuation and the creatinine denominator problem Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the…		2	10k	6d
The anatomy of a question that gets answered within an hour — does this still hold? Start Here › How to Ask beginner friendly onboarding site feedback guidelines The anatomy of a question that gets answered within an hour — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context…	+19	23	40k	14d
Substitution between formats during a shortage — what changed since Access › Shortages shortage formulary FDA compounding Solved Substitution between formats during a shortage — what changed since — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is…	+17	21	2.7k	9d
Here for the analytics and not much else Lounge › Introductions onboarding beginner friendly Here for the analytics and not much else — setting out what I have, and where I think it stops being reliable. Lower-stakes topic, but the sourcing rule still applies if anyone makes a claim. Something…	+93	102	10k	16h
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs matter Practice › Interactions hypoglycaemia metformin insulin needs a source Solved Delayed gastric emptying and oral medication absorption: which drugs matter Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I…	+63	74	11k	1d
Leak-back after withdrawal and whether you lost a meaningful dose Practice › Administration missed dose injection site reaction injection site rotation aseptic technique Posting this under the heading it deserves: Leak-back after withdrawal and whether you lost a meaningful dose Everything below is what sits behind that. Reporting something rather than asking about it, in…		2	3k	3h
Type 1 diabetes: off-label use and the evidence gap Clinical › Special populations pregnancy & planning bariatric surgery history disordered eating Solved On the subject in the title: Type 1 diabetes: off-label use and the evidence gap Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the difference…		2	2.3k	1d

Sponsored PeptideMeter — peptide analytics and supplier verificationPurity analysis and structured supplier verification, published as dated records rather than scores. Referenced throughout our sourcing documentation.View analytics →