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1,535 topics · page 3 of 40

Topic	Participants	Replies	Views	Activity
About the Welcome category Start Here › Welcome onboarding guidelines beginner friendly Pinned Wiki Introductions, orientation, and the pinned reading list for new members. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a note.…	+4	8	11k	27d
Personal or family history of medullary thyroid carcinoma Safety › Contraindications thyroid C-cell question pancreatitis pregnancy & planning Personal or family history of medullary thyroid carcinoma Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+31	37	709	26d
The five documentation pages worth reading before you post anything — a second dataset Start Here › Welcome beginner friendly trust levels guidelines onboarding Solved On the subject in the title: The five documentation pages worth reading before you post anything — a second dataset Working notes rather than a conclusion. Question in the title. Context below, and I have…		2	24k	1d
A site rotation scheme that is easy enough to actually follow — a second dataset Practice › Administration subcutaneous injection needle gauge & length injection site rotation missed dose A site rotation scheme that is easy enough to actually follow — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated,…	+6	10	1.2k	7h
Follow-up: Signs of dehydration worth acting on Safety › Adverse events delayed gastric emptying pancreatitis hypoglycaemia Posting this under the heading it deserves: Signs of dehydration worth acting on Everything below is what sits behind that. General question, not a request for advice about my own care — I know the difference…	+35	39	9.8k	1d
Retatrutide mass and identity: what a report should show Compounds › Retatrutide TRIUMPH programme preprint retatrutide effect size Solved Posting this under the heading it deserves: Retatrutide mass and identity: what a report should show Everything below is what sits behind that. Comparing SURMOUNT-4 ( JAMA , 2024) with STEP 4 ( JAMA , 2021)…	+22	27	872	22h
Deamidation and the close-eluting pair it produces — the long version Analytics › Impurities & related substances counter-ion content endotoxin testing data table Posting this under the heading it deserves: Deamidation and the close-eluting pair it produces — the long version Everything below is what sits behind that. I would like to understand what this number means…		3	347	24d
Reading a rodent study on a secretagogue without over-extrapolating — the long version Compounds › Secretagogues & GH axis observational data tesamorelin ipamorelin needs a source Reading a rodent study on a secretagogue without over-extrapolating — the long version — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support…	+59	66	30k	4h
Why pulsatile secretion matters for interpreting secretagogue claims Compounds › Secretagogues & GH axis CJC-1295 GHRP class tesamorelin Why pulsatile secretion matters for interpreting secretagogue claims — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SURPASS-2 ( N Engl J Med , 2021) cited…	+5	9	1.6k	15h
Publication bias detection and its low power Evidence › Meta-analyses heterogeneity publication bias effect size On the subject in the title: Publication bias detection and its low power Working notes rather than a conclusion. I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a claim I do not think it…		2	3.2k	1d
Stepping down deliberately, and how to do it without losing progress — what changed since Practice › Dosing & titration tirzepatide semaglutide titration missed dose Under review Posting this under the heading it deserves: Stepping down deliberately, and how to do it without losing progress — what changed since Everything below is what sits behind that. Practical question with the…	+94	99	29k	2d
Repeatability versus intermediate precision — what changed since Analytics › Method validation recovery precision & repeatability linearity system suitability Posting this under the heading it deserves: Repeatability versus intermediate precision — what changed since Everything below is what sits behind that. Working through the identity arithmetic and I would like…		4	21k	5h
Aggregate verification data across the directory, with caveats Sourcing › Independent verification Medutest blind sampling PeptideMeter Under review On the subject in the title: Aggregate verification data across the directory, with caveats Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…	+64	74	4.6k	14h
Muscle cramps: the ordinary causes before the exotic ones — a second dataset Practice › Side effects constipation delayed gastric emptying fatigue hair shedding Solved Posting this under the heading it deserves: Muscle cramps: the ordinary causes before the exotic ones — a second dataset Everything below is what sits behind that. Reporting something rather than asking about…	+65	77	39k	1d
Why retatrutide discussion here is more cautious than elsewhere — one year on Compounds › Retatrutide TRIUMPH programme effect size preprint retatrutide Asking directly, because I could not find a straight answer: Why retatrutide discussion here is more cautious than elsewhere — one year on Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it…	+92	97	3.6k	20h
Why side effects reset at each escalation and that is not a failure Practice › Side effects constipation nausea fatigue delayed gastric emptying Solved Why side effects reset at each escalation and that is not a failure — that is the question, and I have not found it answered plainly anywhere I have looked. I have read the maintained page on this and I still…	+3	7	11k	14h
GIP receptor agonism and the argument about direction — does this still hold? Pharmacology › Receptor biology long read amylin analogues retatrutide Solved GIP receptor agonism and the argument about direction — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Working through the identity arithmetic…	+10	14	15k	16h
Isotope patterns and why the monoisotopic peak is not the tallest — does this still hold? Analytics › Mass spectrometry charge states counter-ion content high-resolution MS mass error (ppm) Solved Isotope patterns and why the monoisotopic peak is not the tallest — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Working through the identity…		2	4.6k	7h
Request: tag synonyms surfaced in search Meta › Feature requests wiki post translation site feedback Solved On the subject in the title: Request: tag synonyms surfaced in search Working notes rather than a conclusion. Process question about how this site works. I have read the guidelines and the trust-level page…	+23	27	38k	3h
Named, unnamed and unspecified impurities as regulatory categories — the long version Analytics › Impurities & related substances HPLC data table forced degradation counter-ion content Wiki Named, unnamed and unspecified impurities as regulatory categories — the long version — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical…	+112	120	7.6k	5h
About the Hydration & electrolytes category Nutrition & Training › Hydration & electrolytes fatigue blood pressure heart rate Pinned Wiki Fluid intake, sodium, potassium and magnesium, and the very ordinary causes of week-two malaise. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…		4	3.6k	18h
What consumer-accessible tests can and cannot determine — a second dataset Analytics › Home & field testing ELISA LOD & LOQ third-party testing documentation quality Solved What consumer-accessible tests can and cannot determine — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know…	+117	131	45k	10h
Revisiting: How this community labels and discusses unrefereed work Evidence › Preprints needs a source risk of bias preprint effect size Solved Revisiting: How this community labels and discusses unrefereed work Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med , 2024) cited in…	+31	35	7k	1d
Second pass at: Reading a trial's population section before its results Evidence › Trials open label intention to treat estimand surrogate endpoints Solved Second pass at: Reading a trial's population section before its results Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021) cited in…		4	9.5k	10h
[2026 update] Journal club: what we got wrong in an earlier session Evidence › Journal club journal club effect size estimand number needed to treat Solved Journal club: what we got wrong in an earlier session — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support of a claim I do not think it…	+5	9	4.2k	1d
About the Syringes & needles category Devices › Syringes & needles syringe units dead volume needle gauge & length Pinned Wiki Insulin syringe graduations, dead volume, gauge and length selection, and reading units correctly. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…		4	45k	1mo
Journal club: what we got wrong in an earlier session Evidence › Journal club number needed to treat effect size randomised trial journal club On the subject in the title: Journal club: what we got wrong in an earlier session Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before posting; the…	+114	125	2.5k	23h
NHS criteria and how they are applied in practice Regional › UK & Ireland NHS cost per milligram personal import MHRA NHS criteria and how they are applied in practice — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines…	+37	42	31k	2d
Follow-up: Reading an interaction checker output critically Practice › Interactions insulin hypoglycaemia delayed gastric emptying needs a source Solved Reading an interaction checker output critically — setting out what I have, and where I think it stops being reliable. I have read the maintained page on this and I still have a gap, so I am asking rather…	+62	66	13k	2d
The report format the maintainers ask for, and why each field is there Sourcing › Vendor reports disputed documentation quality batch & lot numbers certificate of analysis Solved On the subject in the title: The report format the maintainers ask for, and why each field is there Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…		4	6.3k	1d