Tags · Evidence

heterogeneity

Variation in effect across studies or subgroups.

35 topics 12 solved Group: Evidence

35 topics · page 1 of 2

Topic	Participants	Replies	Views	Activity
When a network meta-analysis is defensible and when it is not Evidence › Meta-analyses effect size heterogeneity publication bias Solved When a network meta-analysis is defensible and when it is not I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing SUSTAIN 6 ( N Engl J Med , 2016) with LEADER (…		2	27k	4h
[2026 update] Correlation in a self-tracked dataset: what it can support Research Methods › Statistics number needed to treat effect size worked example heterogeneity Posting this under the heading it deserves: Correlation in a self-tracked dataset: what it can support Everything below is what sits behind that. I have seen SURMOUNT-4 ( JAMA , 2024) cited in support of a…		2	31k	6h
Revisiting: What pooling buys you and what it destroys Evidence › Meta-analyses heterogeneity effect size publication bias Solved On the subject in the title: Revisiting: What pooling buys you and what it destroys Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before posting; the…	+97	107	4k	19h
Risk-of-bias tools and the judgement they conceal — does this still hold? Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Solved Risk-of-bias tools and the judgement they conceal — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021)…	+26	30	5.8k	23h
Publication bias detection and its low power Evidence › Meta-analyses heterogeneity publication bias effect size On the subject in the title: Publication bias detection and its low power Working notes rather than a conclusion. I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a claim I do not think it…		2	3.2k	1d
Sample size intuition for a personal experiment — does this still hold? Research Methods › Statistics effect size heterogeneity number needed to treat Solved Sample size intuition for a personal experiment — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Comparing STEP 1 ( N Engl J Med , 2021) with…	+33	38	26k	23d
What a confidence interval means, from scratch Research Methods › Statistics number needed to treat confounding worked example heterogeneity What a confidence interval means, from scratch — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen STEP 8 ( JAMA , 2022) cited in support of a claim I do not…		2	2.6k	2mo
Measurement error in home scales, with a worked standard deviation — the long version Research Methods › Statistics number needed to treat worked example heterogeneity effect size Solved On the subject in the title: Measurement error in home scales, with a worked standard deviation — the long version Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022).…	+96	105	2k	2mo
Publication bias detection and its low power — does this still hold? Evidence › Meta-analyses publication bias risk of bias meta-analysis heterogeneity Solved The question in the title: Publication bias detection and its low power — does this still hold? I will give what I have already checked below so nobody repeats it. I have seen LEADER ( N Engl J Med , 2016)…	+24	28	2.4k	3mo
Second pass at: What pooling buys you and what it destroys Evidence › Meta-analyses risk of bias meta-analysis heterogeneity Posting this under the heading it deserves: Second pass at: What pooling buys you and what it destroys Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of a claim…	+32	36	19k	4mo
Prediction intervals and why they are more honest than confidence intervals Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Solved Closed Posting this under the heading it deserves: Prediction intervals and why they are more honest than confidence intervals Everything below is what sits behind that. Comparing SURMOUNT-4 ( JAMA , 2024) with FLOW…	+21	25	46k	4mo
Measurement error in home scales, with a worked standard deviation Research Methods › Statistics effect size heterogeneity number needed to treat confounding Solved Wiki Measurement error in home scales, with a worked standard deviation Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet , 2021) with STEP 1 ( N Engl…	+26	31	4.3k	4mo
Heterogeneity as information rather than as a nuisance Evidence › Meta-analyses heterogeneity risk of bias meta-analysis effect size Posting this under the heading it deserves: Heterogeneity as information rather than as a nuisance Everything below is what sits behind that. Session topic: SCALE ( N Engl J Med , 2015). Please read it before…	+88	95	1.2k	6mo
Measurement error in home scales, with a worked standard deviation — a second dataset Research Methods › Statistics effect size confounding heterogeneity number needed to treat Solved Measurement error in home scales, with a worked standard deviation — a second dataset — setting out what I have, and where I think it stops being reliable. Comparing FLOW ( N Engl J Med , 2024) with SURPASS-2…		2	13k	7mo
About the Statistics category Research Methods › Statistics effect size number needed to treat heterogeneity Pinned Wiki Effect sizes, intervals, multiplicity, and the difference between absent and undetected. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+4	8	2.3k	7mo
Pooling trials with different estimands — what changed since Evidence › Meta-analyses publication bias risk of bias meta-analysis effect size Pooling trials with different estimands — what changed since — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SURPASS-4 ( Lancet , 2021) and finding…	+57	64	12k	7mo
What pooling buys you and what it destroys Evidence › Meta-analyses publication bias risk of bias meta-analysis heterogeneity Solved The question in the title: What pooling buys you and what it destroys I will give what I have already checked below so nobody repeats it. Comparing SURMOUNT-2 ( Lancet , 2023) with LEADER ( N Engl J Med ,…	+74	83	6.6k	8mo
What a confidence interval means, from scratch — the long version Research Methods › Statistics effect size worked example confounding number needed to treat The question in the title: What a confidence interval means, from scratch — the long version I will give what I have already checked below so nobody repeats it. I have seen SURMOUNT-2 ( Lancet , 2023) cited…	+16	20	2.3k	8mo
Risk-of-bias tools and the judgement they conceal Evidence › Meta-analyses meta-analysis heterogeneity publication bias effect size Wiki Risk-of-bias tools and the judgement they conceal Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of a claim I do…	+8	12	21k	11mo
Multiplicity when you track fifteen variables Research Methods › Statistics effect size heterogeneity confounding worked example Solved Multiplicity when you track fifteen variables — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SURMOUNT-OSA ( N Engl J Med , 2024) and finding…		2	60k	11mo
[2026 update] Heterogeneity as information rather than as a nuisance Evidence › Meta-analyses publication bias heterogeneity meta-analysis Heterogeneity as information rather than as a nuisance Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I…		4	32k	11mo
Regression to the mean in progress reports Research Methods › Statistics number needed to treat heterogeneity confounding effect size On the subject in the title: Regression to the mean in progress reports Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before posting; the discussion…	+30	34	49k	12mo
Random versus fixed effects: choosing rather than defaulting Evidence › Meta-analyses effect size publication bias risk of bias heterogeneity Closed Random versus fixed effects: choosing rather than defaulting — setting out what I have, and where I think it stops being reliable. Session topic: FLOW ( N Engl J Med , 2024). Please read it before posting;…	+16	20	22k	13mo
About the Meta-analyses category Evidence › Meta-analyses meta-analysis heterogeneity publication bias Pinned Wiki Pooled estimates, heterogeneity, publication bias, and when pooling was a mistake. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	15k	13mo
Individual participant data versus aggregate data Evidence › Meta-analyses heterogeneity risk of bias meta-analysis publication bias Posting this under the heading it deserves: Individual participant data versus aggregate data Everything below is what sits behind that. Session topic: SCALE ( N Engl J Med , 2015). Please read it before…	+30	34	64k	14mo
Second pass at: Regression to the mean in progress reports Research Methods › Statistics effect size worked example heterogeneity Second pass at: Regression to the mean in progress reports Writing it up because I had to work it out twice and would rather nobody else did. Comparing SUSTAIN 6 ( N Engl J Med , 2016) with STEP 4 ( JAMA ,…	+71	75	4k	17mo
Coming back to: Reading a meta-analysis you disagree with, fairly Evidence › Meta-analyses meta-analysis publication bias heterogeneity risk of bias Reading a meta-analysis you disagree with, fairly Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of a claim I do…	+30	34	9.3k	17mo
Random versus fixed effects: choosing rather than defaulting — a second dataset Evidence › Meta-analyses heterogeneity risk of bias publication bias On the subject in the title: Random versus fixed effects: choosing rather than defaulting — a second dataset Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it…	+95	106	20k	17mo
Second pass at: Multiplicity when you track fifteen variables Research Methods › Statistics number needed to treat confounding effect size worked example Posting this under the heading it deserves: Second pass at: Multiplicity when you track fifteen variables Everything below is what sits behind that. I have seen SCALE ( N Engl J Med , 2015) cited in support…		2	12k	18mo
Sample size intuition for a personal experiment Research Methods › Statistics number needed to treat heterogeneity confounding effect size On the subject in the title: Sample size intuition for a personal experiment Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before posting; the discussion is…		4	62k	18mo

Sponsored PeptideMeter — peptide analytics and supplier verificationPurity analysis and structured supplier verification, published as dated records rather than scores. Referenced throughout our sourcing documentation.View analytics →