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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 40 of 40

Topic	Participants	Replies	Views	Activity
Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Evidence › Journal club randomised trial effect size journal club risk of bias Solved Posting this under the heading it deserves: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Everything below is what sits behind that. Comparing SURMOUNT-4 ( JAMA , 2024) with SCALE ( N Engl J…	+47	51	617	16mo
UK access routes, dated and sourced Regional › UK & Ireland NHS personal import MHRA Closed UK access routes, dated and sourced Writing it up because I had to work it out twice and would rather nobody else did. Documenting an access outcome, dated, because everything in this category expires. As of…		2	5.8k	15mo
[2026 update] US compounding rules and how they changed Regional › North America FDA compounding insurance Solved US compounding rules and how they changed Writing it up because I had to work it out twice and would rather nobody else did. Documenting an access outcome, dated, because everything in this category expires.…	+32	37	7.4k	10mo
Deconvolution of a multiply charged envelope Analytics › Mass spectrometry MALDI-TOF charge states mass error (ppm) counter-ion content Closed Deconvolution of a multiply charged envelope — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it checked. tirzepatide has a…		2	63	10mo
Journal club: STEP 4 and what a withdrawal design can prove Evidence › Journal club randomised trial risk of bias effect size Solved On the subject in the title: Journal club: STEP 4 and what a withdrawal design can prove Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before…	+61	65	2k	13mo
Requesting a page: what makes a good request Documentation › Wiki requests wiki post maintainership promoted to docs review date Requesting a page: what makes a good request Writing it up because I had to work it out twice and would rather nobody else did. Nominating something for promotion into the documentation commons. The topic in…	+65	71	9.3k	15mo
Counter-ion form: the field almost nobody reports — one year on Analytics › COA interpretation documentation quality reference standards batch & lot numbers On the subject in the title: Counter-ion form: the field almost nobody reports — one year on Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a…	+121	139	31k	16mo
Follow-up: Attributing a new peak: degradation product or excipient? Analytics › Impurities & related substances water content HPLC forced degradation endotoxin testing Solved Attributing a new peak: degradation product or excipient? I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first…	+15	19	671	17mo
[2026 update] Sulphur-smelling eructation: mechanism and what helps Practice › Side effects fatigue delayed gastric emptying hair shedding vomiting Posting this under the heading it deserves: Sulphur-smelling eructation: mechanism and what helps Everything below is what sits behind that. I have read the maintained page on this and I still have a gap, so…		2	7.3k	10mo
SNAC and the mechanism of oral peptide absorption Compounds › Oral incretins orforglipron randomised trial PIONEER programme oral semaglutide On the subject in the title: SNAC and the mechanism of oral peptide absorption Working notes rather than a conclusion. Comparing SELECT ( N Engl J Med , 2023) with SURPASS-4 ( Lancet , 2021) and finding the…	+13	17	14k	17mo
A ten-fold dose error caught before injection Devices › Syringes & needles needle gauge & length worked example syringe units dead volume Closed A ten-fold dose error caught before injection — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the pattern is useful to anyone…	+95	103	26k	10mo
What a 2 ppm match establishes, and what it does not Analytics › Mass spectrometry high-resolution MS charge states LC-MS MALDI-TOF What a 2 ppm match establishes, and what it does not — that is the question, and I have not found it answered plainly anywhere I have looked. Working through the identity arithmetic and I would like it…	+56	60	5.2k	9mo
[2026 update] Heterogeneity as information rather than as a nuisance Evidence › Meta-analyses publication bias heterogeneity meta-analysis Heterogeneity as information rather than as a nuisance Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I…		4	32k	11mo
Validating a method you did not develop — does this still hold? Analytics › Method validation stability-indicating method LOD & LOQ precision & repeatability recovery Solved Validating a method you did not develop — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what this number means…	+128	148	47k	16mo
Revisiting: Filter needles: when they help and what they cost you Devices › Syringes & needles worked example needle gauge & length subcutaneous injection dead volume Closed Revisiting: Filter needles: when they help and what they cost you — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have been doing the…	+48	52	6.6k	11mo
Second pass at: Obstructive sleep apnoea and a hard endpoint in this class Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea MASH / hepatic steatosis chronic kidney disease Second pass at: Obstructive sleep apnoea and a hard endpoint in this class — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The…		2	726	14mo
Reading order for a first week here, and what to skip until later Start Here › Welcome onboarding guidelines beginner friendly trust levels Reading order for a first week here, and what to skip until later Writing it up because I had to work it out twice and would rather nobody else did. I want to check my reasoning rather than get a conclusion.…	+112	117	3.1k	15mo
Follow-up: Requesting a page: what makes a good request Documentation › Wiki requests promoted to docs review date maintainership wiki post Solved On the subject in the title: Requesting a page: what makes a good request Working notes rather than a conclusion. Nominating something for promotion into the documentation commons. The topic in question keeps…	+44	50	64k	13mo
Coming back to: How to tell whether your question is already answered on a maintained page Start Here › Welcome onboarding guidelines beginner friendly trust levels How to tell whether your question is already answered on a maintained page I have a specific reason for asking rather than idle curiosity, and the context is below. Question in the title. Context below, and I…		2	808	17mo
Airline travel with a temperature-sensitive injectable — what changed since Devices › Cold chain cold chain storage temperature excursion Airline travel with a temperature-sensitive injectable — what changed since Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I…	+89	95	5.3k	9mo
Assessing a warm arrival: the decision process Sourcing › Logistics temperature excursion cold chain shipping Closed Posting this under the heading it deserves: Assessing a warm arrival: the decision process Everything below is what sits behind that. A logistics question, since the answers here are usually better than…	+15	19	3.3k	16mo
Consistent declarations and why they matter more than clever ones Sourcing › Logistics packaging temperature excursion shipping customs Consistent declarations and why they matter more than clever ones — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better than…	+146	164	2k	17mo
Coming back to: Official shortage notices and what they authorise Access › Shortages shortage FDA formulary Solved Closed Official shortage notices and what they authorise — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines…	+39	43	510	17mo
Adjudicated events and why the definition matters — the long version Evidence › Trials intention to treat estimand randomised trial discontinuation & dropout Adjudicated events and why the definition matters — the long version Writing it up because I had to work it out twice and would rather nobody else did. Comparing SURPASS-4 ( Lancet , 2021) with STEP 4 ( JAMA…	+125	146	13k	15mo
Revisiting: Aggregate verification data across the directory, with caveats Sourcing › Independent verification PeptideMeter third-party testing blind sampling Medutest Closed Revisiting: Aggregate verification data across the directory, with caveats — setting out what I have, and where I think it stops being reliable. I would like to talk about documentation quality as a signal,…	+22	26	23k	17mo
Why side effects reset at each escalation and that is not a failure — the long version Practice › Side effects nausea vomiting fatigue delayed gastric emptying The question in the title: Why side effects reset at each escalation and that is not a failure — the long version I will give what I have already checked below so nobody repeats it. Reporting something rather…		2	46k	17mo
Why a pen's dose steps are fixed and what that costs you — one year on Devices › Pens & autoinjectors storage subcutaneous injection missed dose Solved Closed Asking directly, because I could not find a straight answer: Why a pen's dose steps are fixed and what that costs you — one year on I have read the maintained page on this and I still have a gap, so I am…	+30	34	2.9k	11mo
Reading a chromatogram someone posted without axes Analytics › HPLC & UHPLC HPLC UV & DAD detection gradient method data table Reading a chromatogram someone posted without axes — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate in front…	+47	55	9.4k	13mo
Food effects on oral incretin absorption: what is documented Compounds › Oral incretins PIONEER programme SOUL trial randomised trial oral semaglutide Solved Under review On the subject in the title: Food effects on oral incretin absorption: what is documented Working notes rather than a conclusion. Session topic: SURMOUNT-1 ( N Engl J Med , 2022). Please read it before…		2	4.4k	12mo
About the Datasets category Data & Tools › Datasets data table observational data confounding Pinned Wiki Community-collected datasets, their collection methods, and their limitations. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a…	+6	11	42k	12mo