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New topics page 38

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1,535 topics · page 38 of 40

Topic	Participants	Replies	Views	Activity
Follow-up: How much fluid is actually needed, and how you would know Nutrition & Training › Hydration & electrolytes blood pressure heart rate fatigue How much fluid is actually needed, and how you would know — that is the question, and I have not found it answered plainly anywhere I have looked. Maintenance rather than loss, which is the part of this that…	+17	21	12k	13mo
Payment mechanics and the recovery options that do not exist — what changed since Sourcing › Payments documentation quality payments research use only Solved On the subject in the title: Payment mechanics and the recovery options that do not exist — what changed since Working notes rather than a conclusion. A logistics question, since the answers here are usually…	+14	18	17k	13mo
Storing a pen in use versus a pen unopened — what changed since Devices › Pens & autoinjectors subcutaneous injection dead volume missed dose Posting this under the heading it deserves: Storing a pen in use versus a pen unopened — what changed since Everything below is what sits behind that. I have read the maintained page on this and I still have…		2	206	15mo
One lot is one lot: when a report becomes a pattern — the long version Sourcing › Vendor reports third-party testing Janoshik Analytical certificate of analysis batch & lot numbers Closed One lot is one lot: when a report becomes a pattern — the long version — setting out what I have, and where I think it stops being reliable. Structured report rather than an opinion, following the format the…	+137	152	46k	16mo
Follow-up: Review cadence: how often is a page actually re-checked? Documentation › Doc review wiki post citation check maintainership promoted to docs Solved The question in the title: Review cadence: how often is a page actually re-checked? I will give what I have already checked below so nobody repeats it. Nominating something for promotion into the…		2	64k	16mo
Why the timeline is on the right and not the left Meta › Site feedback moderation site feedback guidelines Solved Why the timeline is on the right and not the left — that is the question, and I have not found it answered plainly anywhere I have looked. Nominating something for promotion into the documentation commons.…	+67	73	19k	10mo
The C-cell question: rodent findings and their human context Compounds › Semaglutide STEP programme type 2 diabetes effect size Closed Posting this under the heading it deserves: The C-cell question: rodent findings and their human context Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of a…	+41	45	24k	12mo
Counter-ion content and its effect on measured mass Analytics › Mass spectrometry high-resolution MS charge states MALDI-TOF LC-MS Solved On the subject in the title: Counter-ion content and its effect on measured mass Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. retatrutide has a…	+100	108	45k	12mo
Coverage for the indication versus for the drug Access › Insurance & coverage insurance formulary appeals prior authorisation Coverage for the indication versus for the drug — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines the…	+70	79	18k	14mo
Second pass at: Pen dose counters: what a click does and does not guarantee Devices › Pens & autoinjectors dead volume storage subcutaneous injection Second pass at: Pen dose counters: what a click does and does not guarantee — setting out what I have, and where I think it stops being reliable. A question about technique rather than about dose. I have been…	+63	68	51k	13mo
Maintainer handover: how it works Meta › Wiki maintenance review date moderation citation check wiki post On the subject in the title: Maintainer handover: how it works Working notes rather than a conclusion. Process question about how this site works. I have read the guidelines and the trust-level page and I…	+76	82	14k	16mo
About the Progress reports category Outcomes › Progress reports effect size DXA data table Pinned Wiki Longitudinal self-reports with the method stated. Scales, tape measures, and their error bars. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…		4	139	16mo
Hepatic steatosis: what the MASH trial evidence supports Clinical › Comorbidities MASH / hepatic steatosis PCOS type 2 diabetes chronic kidney disease Hepatic steatosis: what the MASH trial evidence supports — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in…	+77	83	950	13mo
Follow-up: Journal club: the retatrutide phase 2 obesity paper Evidence › Journal club randomised trial risk of bias effect size journal club Closed On the subject in the title: Journal club: the retatrutide phase 2 obesity paper Working notes rather than a conclusion. I have seen SURMOUNT-1 ( N Engl J Med , 2022) cited in support of a claim I do not…	+20	24	8.7k	16mo
Why one laboratory's 98.4% and another's 96.1% may not contradict Analytics › Method validation stability-indicating method LOD & LOQ linearity Solved Wiki Why one laboratory's 98.4% and another's 96.1% may not contradict I have a specific reason for asking rather than idle curiosity, and the context is below. A documentation question rather than an analytical…	+28	37	457	7mo
Retatrutide dose escalation in the published trials Compounds › Retatrutide preprint retatrutide effect size Posting this under the heading it deserves: Retatrutide dose escalation in the published trials Everything below is what sits behind that. Session topic: SURPASS-2 ( N Engl J Med , 2021). Please read it…	+149	159	30k	15mo
What to keep a record of at the point of payment Sourcing › Payments documentation quality payments research use only Solved Pinned What to keep a record of at the point of payment — that is the question, and I have not found it answered plainly anywhere I have looked. Structured report rather than an opinion, following the format the…		2	1.8k	16mo
Why plausible mechanism is not evidence of effect Compounds › Repair & healing peptides TB-500 preprint observational data Solved Closed Asking directly, because I could not find a straight answer: Why plausible mechanism is not evidence of effect Session topic: STEP 2 ( Lancet , 2021). Please read it before posting; the discussion is much…	+14	18	57k	13mo
Coming back to: Sample size calculations, read backwards from the published number Evidence › Trials estimand discontinuation & dropout surrogate endpoints randomised trial On the subject in the title: Sample size calculations, read backwards from the published number Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…	+82	88	1.8k	11mo
Certificates issued by the seller versus by a laboratory Analytics › COA interpretation amino acid analysis certificate of analysis documentation quality Posting this under the heading it deserves: Certificates issued by the seller versus by a laboratory Everything below is what sits behind that. I would like to understand what this number means before I…	+58	65	1.2k	15mo
Pen wastage and its effect on real cost — the long version Access › Pricing formulary data table cost per milligram compounding Posting this under the heading it deserves: Pen wastage and its effect on real cost — the long version Everything below is what sits behind that. Documenting an access outcome, dated, because everything in…		2	34k	13mo
Severe gastroparesis and why this class is a poor fit Safety › Contraindications pancreatitis pregnancy & planning delayed gastric emptying Solved On the subject in the title: Severe gastroparesis and why this class is a poor fit Working notes rather than a conclusion. Asking about a population rather than about a person. The published trials in this…		3	62k	13mo
Second pass at: Retatrutide mass and identity: what a report should show Compounds › Retatrutide retatrutide randomised trial effect size Solved Second pass at: Retatrutide mass and identity: what a report should show — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 4 ( JAMA , 2021)…	+65	71	4.6k	13mo
Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Evidence › Journal club randomised trial risk of bias effect size estimand Posting this under the heading it deserves: Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Everything below is what sits behind that. Comparing STEP 8 ( JAMA , 2022) with FLOW…	+58	64	17k	13mo
Follow-up: Is "synergy" the right word for the combination data? Compounds › Cagrilintide & amylin analogues cagrilintide cagrisema amylin analogues effect size Solved Under review Is "synergy" the right word for the combination data? I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a…		2	41k	14mo
Requesting a translation of an existing page Documentation › Wiki requests wiki post maintainership review date Requesting a translation of an existing page — setting out what I have, and where I think it stops being reliable. Process question about how this site works. I have read the guidelines and the trust-level…	+16	20	7.1k	14mo
Antibiotics and a course of something with delayed emptying Practice › Interactions insulin hypoglycaemia needs a source metformin Antibiotics and a course of something with delayed emptying — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the pattern is useful…	+99	108	1.4k	12mo
Splitting a vial for two laboratories: how to do it without ruining both Sourcing › Independent verification blind sampling PeptideMeter third-party testing Medutest Solved Splitting a vial for two laboratories: how to do it without ruining both — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better…	+64	70	4.4k	13mo
Particulates in a reconstituted solution: identifying the likely source — what changed since Analytics › Impurities & related substances water content HPLC forced degradation counter-ion content Particulates in a reconstituted solution: identifying the likely source — what changed since — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what…		2	129	14mo
Second pass at: Journal club: STEP 4 and what a withdrawal design can prove Evidence › Journal club number needed to treat risk of bias journal club effect size Second pass at: Journal club: STEP 4 and what a withdrawal design can prove Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURMOUNT-OSA ( N Engl J Med ,…	+81	90	54k	9mo