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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 36 of 40

Topic	Participants	Replies	Views	Activity
Water content on a certificate and why it changes the arithmetic Analytics › COA interpretation certificate of analysis reference standards batch & lot numbers Closed Water content on a certificate and why it changes the arithmetic — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a…	+19	23	24k	14mo
Metformin co-administration and additive GI effects Practice › Interactions insulin hypoglycaemia metformin delayed gastric emptying Metformin co-administration and additive GI effects Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about it, in case the pattern is…	+28	32	2.1k	15mo
Risk-of-bias tools and the judgement they conceal Evidence › Meta-analyses meta-analysis heterogeneity publication bias effect size Wiki Risk-of-bias tools and the judgement they conceal Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of a claim I do…	+8	12	21k	11mo
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Evidence › Journal club risk of bias number needed to treat randomised trial Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Comparing STEP 2 ( Lancet , 2021) with SURMOUNT-4 ( JAMA , 2024) and…	+118	132	12k	15mo
Reading a rodent study on a secretagogue without over-extrapolating Compounds › Secretagogues & GH axis observational data GHRP class CJC-1295 needs a source Closed Posting this under the heading it deserves: Reading a rodent study on a secretagogue without over-extrapolating Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of…	+50	54	32k	10mo
Guidelines revision: what changed and why — does this still hold? Meta › Announcements trust levels site feedback guidelines moderation Guidelines revision: what changed and why — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Process question about how this site works. I have…		2	58k	7mo
Excipient function in a licensed injectable — the long version Pharmacology › Formulation chemistry sterile water storage bacteriostatic water Posting this under the heading it deserves: Excipient function in a licensed injectable — the long version Everything below is what sits behind that. Working through the identity arithmetic and I would like…		2	100	15mo
Follow-up: Documentation that appears only after payment Sourcing › Red flags disputed mislabelling underdosing documentation quality Wiki Posting this under the heading it deserves: Documentation that appears only after payment Everything below is what sits behind that. I would like to talk about documentation quality as a signal, separately…	+82	87	50k	14mo
Reflectance and photometric devices: precision in practice Analytics › Home & field testing third-party testing documentation quality LOD & LOQ Solved On the subject in the title: Reflectance and photometric devices: precision in practice Working notes rather than a conclusion. I would like to understand what this number means before I repeat it anywhere. A…		2	2.2k	10mo
Micronutrient status when intake falls substantially Clinical › Bloodwork lipase & amylase thyroid function lipid panel HbA1c Solved Wiki Closed On the subject in the title: Micronutrient status when intake falls substantially Working notes rather than a conclusion. Asking about a population rather than about a person. The published trials in this…	+26	30	367	11mo
Shakes versus food: a pragmatic assessment — the long version Nutrition & Training › Protein & intake micronutrients fatigue constipation On the subject in the title: Shakes versus food: a pragmatic assessment — the long version Working notes rather than a conclusion. Maintenance rather than loss, which is the part of this that almost nobody…	+36	41	28k	14mo
Comparing tirzepatide and semaglutide is harder than the tables suggest Compounds › Tirzepatide SURMOUNT programme randomised trial effect size Posting this under the heading it deserves: Comparing tirzepatide and semaglutide is harder than the tables suggest Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with STEP…		2	3.8k	10mo
Coming back to: Checking someone else's arithmetic: a worked example thread Practice › Reconstitution concentration maths reconstitution bacteriostatic water dead volume Posting this under the heading it deserves: Checking someone else's arithmetic: a worked example thread Everything below is what sits behind that. Practical question with the units stated, because I have seen…	+13	17	293	11mo
Regression to the mean in progress reports Research Methods › Statistics number needed to treat heterogeneity confounding effect size On the subject in the title: Regression to the mean in progress reports Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before posting; the discussion…	+30	34	49k	12mo
A pen that felt like it delivered nothing: diagnosing it afterwards Devices › Pens & autoinjectors storage subcutaneous injection missed dose dead volume Solved On the subject in the title: A pen that felt like it delivered nothing: diagnosing it afterwards Working notes rather than a conclusion. A question about technique rather than about dose. I have been doing…	+35	39	584	6mo
Relative retention time as a better inter-laboratory comparator Analytics › Method validation linearity recovery precision & repeatability stability-indicating method On the subject in the title: Relative retention time as a better inter-laboratory comparator Working notes rather than a conclusion. Posting the method first, because I know what the first three replies will…	+7	11	28k	14mo
Reading a trial's population section before its results — does this still hold? Evidence › Trials randomised trial open label intention to treat discontinuation & dropout Closed Reading a trial's population section before its results — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen STEP 1 ( N Engl J Med ,…	+140	154	5.4k	14mo
Why plausible mechanism is not evidence of effect — one year on Compounds › Repair & healing peptides needs a source preprint BPC-157 Solved Closed The question in the title: Why plausible mechanism is not evidence of effect — one year on I will give what I have already checked below so nobody repeats it. Session topic: STEP 4 ( JAMA , 2021). Please read…	+3	7	3.6k	13mo
Vagal afferents and the gut-brain pathway Pharmacology › Receptor biology semaglutide tirzepatide retatrutide long read On the subject in the title: Vagal afferents and the gut-brain pathway Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in front of me that…	+5	9	44k	13mo
Research-use-only status: what it means legally and practically — does this still hold? Compounds › Other compounds custom synthesis mislabelling needs a source research use only Solved Pinned Asking directly, because I could not find a straight answer: Research-use-only status: what it means legally and practically — does this still hold? Session topic: SELECT ( N Engl J Med , 2023). Please read…		2	309	9mo
Why oral semaglutide needs an absorption enhancer at all Compounds › Oral incretins randomised trial orforglipron oral semaglutide SOUL trial Solved Why oral semaglutide needs an absorption enhancer at all I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen STEP 1 ( N Engl J Med , 2021) cited in support of…	+59	65	61k	7mo
Ipamorelin selectivity claims and where they came from — a second dataset Compounds › Secretagogues & GH axis CJC-1295 GHRP class tesamorelin ipamorelin Posting this under the heading it deserves: Ipamorelin selectivity claims and where they came from — a second dataset Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021)…		2	27k	14mo
Reaching a dose and staying there for a year: a longitudinal note Practice › Dosing & titration worked example tirzepatide titration semaglutide Reaching a dose and staying there for a year: a longitudinal note Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a…		2	763	15mo
Journal club: the retatrutide phase 2 obesity paper Evidence › Journal club estimand number needed to treat journal club randomised trial Solved Journal club: the retatrutide phase 2 obesity paper — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim I do not think it…	+7	11	33k	7mo
Which panel is worth repeating and which is worth ignoring Clinical › Bloodwork eGFR & renal function liver enzymes HbA1c Solved The question in the title: Which panel is worth repeating and which is worth ignoring I will give what I have already checked below so nobody repeats it. General question, not a request for advice about my…	+125	133	17k	10mo
Validating a calculator against hand arithmetic — what changed since Data & Tools › Calculators concentration maths site feedback worked example Solved Posting this under the heading it deserves: Validating a calculator against hand arithmetic — what changed since Everything below is what sits behind that. Working through the identity arithmetic and I would…	+121	137	21k	13mo
Trial registration and comparing the protocol with the paper Evidence › Trials randomised trial open label intention to treat Trial registration and comparing the protocol with the paper — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016) cited in support of a claim I do…	+38	44	4.8k	10mo
Carryover and the ghost peak from last week's standard Analytics › HPLC & UHPLC data table UV & DAD detection peak integration system suitability On the subject in the title: Carryover and the ghost peak from last week's standard Working notes rather than a conclusion. Posting the method first, because I know what the first three replies will otherwise…	+80	92	16k	16mo
Mood changes: monitoring, and when to involve a professional Wellbeing › Mental health mood beginner friendly disordered eating Mood changes: monitoring, and when to involve a professional — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I know the…		2	362	13mo
A report I filed that turned out to be wrong, and the correction Sourcing › Vendor reports certificate of analysis disputed third-party testing A report I filed that turned out to be wrong, and the correction Writing it up because I had to work it out twice and would rather nobody else did. Structured report rather than an opinion, following the…	+124	132	12k	13mo