Tags · Technique

linearity

Response proportionality across the working range.

24 topics 6 solved Group: Technique

24 topics

Topic	Participants	Replies	Views	Activity
Repeatability versus intermediate precision — what changed since Analytics › Method validation recovery precision & repeatability linearity system suitability Posting this under the heading it deserves: Repeatability versus intermediate precision — what changed since Everything below is what sits behind that. Working through the identity arithmetic and I would like…		4	21k	5h
Revisiting: Spike-and-recover accuracy for a peptide assay Analytics › Method validation LOD & LOQ system suitability stability-indicating method linearity Revisiting: Spike-and-recover accuracy for a peptide assay — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it anywhere.…		2	6.8k	21h
Specificity, linearity, accuracy, precision, range, robustness — with real criteria Analytics › Method validation precision & repeatability LOD & LOQ linearity Specificity, linearity, accuracy, precision, range, robustness — with real criteria Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this…	+44	48	12k	1d
Coming back to: Specificity, linearity, accuracy, precision, range, robustness — with real criteria Analytics › Method validation linearity recovery precision & repeatability system suitability On the subject in the title: Specificity, linearity, accuracy, precision, range, robustness — with real criteria Working notes rather than a conclusion. Posting the method first, because I know what the first…	+93	99	1.4k	6d
Validating a method you did not develop Analytics › Method validation precision & repeatability recovery linearity stability-indicating method On the subject in the title: Validating a method you did not develop Working notes rather than a conclusion. I would like to understand what this number means before I repeat it anywhere. A VendorInvestigate…	+10	14	15k	3mo
Sample handling between despatch and injection Analytics › Method validation stability-indicating method LOD & LOQ linearity precision & repeatability Sample handling between despatch and injection Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+63	68	2.4k	3mo
Second pass at: Robustness: the parameters worth deliberately varying Analytics › Method validation linearity LOD & LOQ recovery system suitability On the subject in the title: Second pass at: Robustness: the parameters worth deliberately varying Working notes rather than a conclusion. I would like to understand what this number means before I repeat it…	+61	66	9.5k	3mo
Spike-and-recover accuracy for a peptide assay Analytics › Method validation linearity system suitability stability-indicating method LOD & LOQ Wiki Posting this under the heading it deserves: Spike-and-recover accuracy for a peptide assay Everything below is what sits behind that. A documentation question rather than an analytical one. I have a…	+121	126	1.5k	4mo
About the Method validation category Analytics › Method validation stability-indicating method linearity LOD & LOQ Pinned Wiki Specificity, linearity, precision, accuracy, robustness, system suitability, and why two labs disagree. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…	+1	5	468	5mo
Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on Analytics › Method validation LOD & LOQ system suitability linearity stability-indicating method Asking directly, because I could not find a straight answer: Why one laboratory's 98.4% and another's 96.1% may not contradict — one year on Working through the identity arithmetic and I would like it…	+10	14	13k	5mo
Revisiting: Sample handling between despatch and injection Analytics › Method validation recovery precision & repeatability linearity LOD & LOQ Posting this under the heading it deserves: Revisiting: Sample handling between despatch and injection Everything below is what sits behind that. Posting the method first, because I know what the first three…	+5	9	1.1k	6mo
Specificity, linearity, accuracy, precision, range, robustness — with real criteria — a second dataset Analytics › Method validation linearity LOD & LOQ recovery Closed On the subject in the title: Specificity, linearity, accuracy, precision, range, robustness — with real criteria — a second dataset Working notes rather than a conclusion. Working through the identity…	+53	58	7.5k	6mo
What a stability-indicating method is and how you demonstrate one Analytics › Method validation linearity precision & repeatability LOD & LOQ Asking directly, because I could not find a straight answer: What a stability-indicating method is and how you demonstrate one Working through the identity arithmetic and I would like it checked. retatrutide…		4	57k	6mo
Why one laboratory's 98.4% and another's 96.1% may not contradict Analytics › Method validation stability-indicating method LOD & LOQ linearity Solved Wiki Why one laboratory's 98.4% and another's 96.1% may not contradict I have a specific reason for asking rather than idle curiosity, and the context is below. A documentation question rather than an analytical…	+28	37	457	7mo
Robustness: the parameters worth deliberately varying Analytics › Method validation stability-indicating method linearity precision & repeatability Robustness: the parameters worth deliberately varying Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an analytical one. I have a…	+53	57	664	8mo
LOD and LOQ: definitions people get wrong Analytics › Method validation precision & repeatability recovery stability-indicating method linearity Closed LOD and LOQ: definitions people get wrong — setting out what I have, and where I think it stops being reliable. A documentation question rather than an analytical one. I have a certificate in front of me that…		2	43k	8mo
An inter-laboratory comparison on one lot, tabulated Analytics › Method validation linearity LOD & LOQ precision & repeatability system suitability Closed On the subject in the title: An inter-laboratory comparison on one lot, tabulated Working notes rather than a conclusion. Working through the identity arithmetic and I would like it checked. semaglutide has a…		3	17k	10mo
Second pass at: LOD and LOQ: definitions people get wrong Analytics › Method validation recovery precision & repeatability linearity LOD & LOQ Posting this under the heading it deserves: Second pass at: LOD and LOQ: definitions people get wrong Everything below is what sits behind that. Working through the identity arithmetic and I would like it…	+47	51	40k	10mo
Repeatability versus intermediate precision Analytics › Method validation precision & repeatability recovery LOD & LOQ linearity Solved Repeatability versus intermediate precision — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies will otherwise be.…	+119	134	34k	13mo
Relative retention time as a better inter-laboratory comparator Analytics › Method validation linearity recovery precision & repeatability stability-indicating method On the subject in the title: Relative retention time as a better inter-laboratory comparator Working notes rather than a conclusion. Posting the method first, because I know what the first three replies will…	+7	11	28k	14mo
When to suspect the method rather than the sample Analytics › Method validation recovery stability-indicating method linearity system suitability Solved When to suspect the method rather than the sample — that is the question, and I have not found it answered plainly anywhere I have looked. Posting the method first, because I know what the first three replies…	+109	115	63k	15mo
Validating a method you did not develop — does this still hold? Analytics › Method validation stability-indicating method LOD & LOQ precision & repeatability recovery Solved Validating a method you did not develop — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what this number means…	+128	148	47k	16mo
What a stability-indicating method is and how you demonstrate one — one year on Analytics › Method validation precision & repeatability system suitability stability-indicating method recovery Solved What a stability-indicating method is and how you demonstrate one — one year on I have a specific reason for asking rather than idle curiosity, and the context is below. A documentation question rather than…	+100	112	15k	19mo
Coming back to: When to suspect the method rather than the sample Analytics › Method validation precision & repeatability LOD & LOQ linearity recovery Solved Wiki When to suspect the method rather than the sample I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the first three…	+116	135	42k	19mo

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