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New topics page 37

Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 37 of 40

Topic	Participants	Replies	Views	Activity
Journal club: indirect comparison between two programmes, defended and attacked — one year on Evidence › Journal club randomised trial risk of bias effect size estimand Posting this under the heading it deserves: Journal club: indirect comparison between two programmes, defended and attacked — one year on Everything below is what sits behind that. Comparing SURPASS-2 ( N…	+45	50	3k	9mo
About the Semaglutide category Compounds › Semaglutide semaglutide STEP programme SELECT trial Pinned Wiki Closed GLP-1 receptor agonist. Dosing, published trial data, tolerability, and formulation questions. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…		4	4.2k	11mo
Import rules for personal quantities, by jurisdiction, dated Sourcing › Regulatory compounding MHRA FDA personal import On the subject in the title: Import rules for personal quantities, by jurisdiction, dated Working notes rather than a conclusion. Structured report rather than an opinion, following the format the maintainers…		3	60k	12mo
Coming back to: Oxidation and deamidation mass shifts, tabulated Analytics › Mass spectrometry LC-MS charge states MALDI-TOF high-resolution MS Oxidation and deamidation mass shifts, tabulated — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it checked. retatrutide has a…	+34	38	4.8k	10mo
How to bring a laboratory report to an appointment usefully Clinical › Bloodwork thyroid function lipase & amylase lipid panel eGFR & renal function How to bring a laboratory report to an appointment usefully — that is the question, and I have not found it answered plainly anywhere I have looked. General question, not a request for advice about my own…		2	41k	14mo
A well-designed study with a badly written abstract Evidence › Study critique disputed effect size risk of bias observational data Posting this under the heading it deserves: A well-designed study with a badly written abstract Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with LEADER ( N Engl J Med ,…	+117	128	7.2k	14mo
Coming back to: Over-dilution: when your dose falls below one readable graduation Practice › Reconstitution worked example dead volume syringe units bacteriostatic water Over-dilution: when your dose falls below one readable graduation Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a…	+90	97	1.1k	7mo
A certificate with no method stated: what can you conclude? Analytics › COA interpretation certificate of analysis batch & lot numbers documentation quality Solved A certificate with no method stated: what can you conclude? I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what this number means before I…	+49	57	1.2k	16mo
Retatrutide phase 2 in type 2 diabetes: the Lancet paper Compounds › Retatrutide randomised trial preprint effect size retatrutide Solved Closed On the subject in the title: Retatrutide phase 2 in type 2 diabetes: the Lancet paper Working notes rather than a conclusion. I have seen STEP 2 ( Lancet , 2021) cited in support of a claim I do not think it…	+12	16	50k	12mo
Review cadence: how often is a page actually re-checked? Documentation › Doc review maintainership review date promoted to docs Solved Asking directly, because I could not find a straight answer: Review cadence: how often is a page actually re-checked? Nominating something for promotion into the documentation commons. The topic in question…	+20	24	20k	15mo
[2026 update] Building a sensible monitoring schedule with your prescriber Clinical › Bloodwork thyroid function HbA1c lipid panel lipase & amylase Closed Posting this under the heading it deserves: Building a sensible monitoring schedule with your prescriber Everything below is what sits behind that. General question, not a request for advice about my own care…	+22	26	5.1k	14mo
Excipient function in a licensed injectable Pharmacology › Formulation chemistry bacteriostatic water cloudy or discoloured solution sterile water Solved Wiki Closed Excipient function in a licensed injectable Writing it up because I had to work it out twice and would rather nobody else did. Posting the method first, because I know what the first three replies will…	+3	7	36k	14mo
Sequence verification for an obscure compound: how it is done Compounds › Other compounds needs a source custom synthesis research use only mislabelling Sequence verification for an obscure compound: how it is done Writing it up because I had to work it out twice and would rather nobody else did. Comparing SUSTAIN 6 ( N Engl J Med , 2016) with SURMOUNT-1 ( N…	+104	114	10k	12mo
Second pass at: Reading a combination trial: attributing effect to components Compounds › Cagrilintide & amylin analogues cagrilintide randomised trial amylin analogues effect size Second pass at: Reading a combination trial: attributing effect to components — setting out what I have, and where I think it stops being reliable. I have seen SURMOUNT-2 ( Lancet , 2023) cited in support of…	+39	43	7.3k	12mo
Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Compounds › Tirzepatide SURMOUNT programme tirzepatide randomised trial effect size Posting this under the heading it deserves: Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Everything below is what sits behind that. I have seen SCALE ( N Engl J Med , 2015) cited in support…	+4	8	14k	8mo
Needle changes between doses on a reusable pen Devices › Pens & autoinjectors subcutaneous injection dead volume missed dose storage Posting this under the heading it deserves: Needle changes between doses on a reusable pen Everything below is what sits behind that. I have read the maintained page on this and I still have a gap, so I am…	+34	38	1.5k	10mo
Coming back to: Cross-border purchase rules within the EU Regional › European Union EMA cost per milligram personal import Cross-border purchase rules within the EU Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included, since that is what…	+12	16	2.8k	11mo
Coming back to: A critique that turned out to be unfair, retracted by its author Evidence › Study critique disputed observational data effect size confounding Closed A critique that turned out to be unfair, retracted by its author — setting out what I have, and where I think it stops being reliable. I have seen STEP 4 ( JAMA , 2021) cited in support of a claim I do not…		2	1.3k	14mo
Comparators chosen for regulatory reasons rather than clinical ones — one year on Evidence › Trials randomised trial intention to treat open label estimand Solved Comparators chosen for regulatory reasons rather than clinical ones — one year on — setting out what I have, and where I think it stops being reliable. Session topic: SURMOUNT-2 ( Lancet , 2023). Please read…	+82	87	1.1k	12mo
Aggregated purity results across four services, with caveats Data & Tools › Datasets observational data site feedback data table Posting this under the heading it deserves: Aggregated purity results across four services, with caveats Everything below is what sits behind that. Working through the identity arithmetic and I would like it…		3	24k	9mo
An appeal that failed, and what I would do differently Access › Insurance & coverage insurance appeals prior authorisation An appeal that failed, and what I would do differently Writing it up because I had to work it out twice and would rather nobody else did. A coverage question with the paperwork detail included, since that is…	+4	8	125	12mo
Why cagrilintide alone is discussed so much less than in combination Compounds › Cagrilintide & amylin analogues effect size amylin analogues cagrisema Solved Closed Why cagrilintide alone is discussed so much less than in combination I have a specific reason for asking rather than idle curiosity, and the context is below. Session topic: SURMOUNT-OSA ( N Engl J Med ,…	+93	108	35k	16mo
Publishing an inconvenient result: a case study Sourcing › Independent verification Medutest VendorInvestigate third-party testing Janoshik Analytical Wiki On the subject in the title: Publishing an inconvenient result: a case study Working notes rather than a conclusion. Structured report rather than an opinion, following the format the maintainers asked for.…	+59	70	992	11mo
Coming back to: Why quantitation is the hard part, not detection Analytics › Home & field testing third-party testing documentation quality ELISA LOD & LOQ Why quantitation is the hard part, not detection — that is the question, and I have not found it answered plainly anywhere I have looked. Posting the method first, because I know what the first three replies…	+86	92	54k	8mo
Follow-up: The lowest dose that does anything: is that a real question? Practice › Dosing & titration worked example missed dose tirzepatide dose reduction Closed The question in the title: The lowest dose that does anything: is that a real question? I will give what I have already checked below so nobody repeats it. I have read the maintained page on this and I still…	+70	75	12k	8mo
A supplier who responds to a discrepancy with silence Sourcing › Red flags underdosing documentation quality moderation mislabelling Closed On the subject in the title: A supplier who responds to a discrepancy with silence Working notes rather than a conclusion. Structured report rather than an opinion, following the format the maintainers asked…		2	6.1k	16mo
What happens after your first post: likes, trust levels, and why none of it matters much Start Here › Welcome guidelines beginner friendly trust levels onboarding Solved Asking directly, because I could not find a straight answer: What happens after your first post: likes, trust levels, and why none of it matters much I want to check my reasoning rather than get a conclusion.…	+15	19	17k	16mo
Documenting a supplier's response to a discrepancy — does this still hold? Sourcing › Vendor reports certificate of analysis third-party testing batch & lot numbers Documenting a supplier's response to a discrepancy — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Structured report rather than an opinion,…	+47	52	58k	16mo
Units, standards, and other things that quietly hold the world together Lounge › Off topic long read beginner friendly Closed Units, standards, and other things that quietly hold the world together — setting out what I have, and where I think it stops being reliable. Lower-stakes topic, but the sourcing rule still applies if anyone…	+33	38	31k	15mo
Asking about a compound your prescriber has not heard of Clinical › Prescriber conversations telehealth prior authorisation beginner friendly Asking about a compound your prescriber has not heard of Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice about my own care — I…	+137	148	15k	11mo