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Tags · Compound

cagrilintide

Long-acting amylin analogue, studied alone and with semaglutide.

19 topics 5 solved Synonyms: cagri Group: Compound

Related in this group: semaglutide · tirzepatide · retatrutide · cagrisema · liraglutide · dulaglutide · exenatide · orforglipron · oral semaglutide · survodutide · mazdutide · amylin analogues

19 topics

Topic	Participants	Replies	Views	Activity
Why cagrilintide alone is discussed so much less than in combination — does this still hold? Compounds › Cagrilintide & amylin analogues cagrisema randomised trial cagrilintide effect size Solved Under review Why cagrilintide alone is discussed so much less than in combination — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURMOUNT-4…	+27	31	1.2k	22h
Historical amylin analogues and what happened to them Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide cagrisema effect size Posting this under the heading it deserves: Historical amylin analogues and what happened to them Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in support of a…	+29	36	31k	1d
What is genuinely unknown about long-term amylin agonism Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide cagrisema amylin analogues Solved What is genuinely unknown about long-term amylin agonism — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing STEP 8 ( JAMA , 2022) with SURMOUNT-1 ( N Engl J Med…	+83	91	46k	1d
Is "synergy" the right word for the combination data? Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide effect size Is "synergy" the right word for the combination data? — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SCALE ( N Engl J Med , 2015). Please read it…	+5	9	13k	25d
Nausea profile of amylin analogues compared with GLP-1 agonists Compounds › Cagrilintide & amylin analogues cagrilintide amylin analogues cagrisema Nausea profile of amylin analogues compared with GLP-1 agonists Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURPASS-4 ( Lancet , 2021). Please read it…	+70	76	3k	4mo
[2026 update] Amylin and gastric emptying: overlapping mechanisms with incretins Compounds › Cagrilintide & amylin analogues amylin analogues randomised trial effect size cagrisema Amylin and gastric emptying: overlapping mechanisms with incretins — setting out what I have, and where I think it stops being reliable. Session topic: FLOW ( N Engl J Med , 2024). Please read it before…	+21	25	44k	5mo
Amylin analogue mechanism: satiety signalling separate from GLP-1 — does this still hold? Compounds › Cagrilintide & amylin analogues cagrisema randomised trial cagrilintide amylin analogues Closed Amylin analogue mechanism: satiety signalling separate from GLP-1 — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Session topic: SURMOUNT-4 (…	+21	25	45k	7mo
Cagrilintide's dosing interval and the pharmacokinetics behind it Compounds › Cagrilintide & amylin analogues effect size randomised trial amylin analogues cagrisema Solved Cagrilintide's dosing interval and the pharmacokinetics behind it — setting out what I have, and where I think it stops being reliable. Comparing LEADER ( N Engl J Med , 2016) with SELECT ( N Engl J Med ,…	+98	105	24k	10mo
The CagriSema phase 2 paper and what a fixed combination buys Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide effect size Posting this under the heading it deserves: The CagriSema phase 2 paper and what a fixed combination buys Everything below is what sits behind that. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in…	+88	93	29k	11mo
Reading a combination trial: attributing effect to components Compounds › Cagrilintide & amylin analogues cagrisema amylin analogues effect size cagrilintide Closed On the subject in the title: Reading a combination trial: attributing effect to components Working notes rather than a conclusion. Session topic: PIONEER 6 ( N Engl J Med , 2019). Please read it before…		4	19k	11mo
About the Cagrilintide & amylin analogues category Compounds › Cagrilintide & amylin analogues cagrilintide cagrisema amylin analogues Pinned Wiki Long-acting amylin analogues alone and in combination. Mechanism, published data, and the open questions. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	1.8k	11mo
Cagrilintide molecular characteristics and analytical considerations Compounds › Cagrilintide & amylin analogues cagrilintide randomised trial amylin analogues cagrisema Cagrilintide molecular characteristics and analytical considerations — setting out what I have, and where I think it stops being reliable. I have seen SURMOUNT-2 ( Lancet , 2023) cited in support of a claim I…		4	41k	12mo
Coming back to: Amylin analogue mechanism: satiety signalling separate from GLP-1 Compounds › Cagrilintide & amylin analogues cagrisema effect size randomised trial cagrilintide On the subject in the title: Amylin analogue mechanism: satiety signalling separate from GLP-1 Working notes rather than a conclusion. I have seen SELECT ( N Engl J Med , 2023) cited in support of a claim I…	+27	31	671	12mo
Second pass at: Reading a combination trial: attributing effect to components Compounds › Cagrilintide & amylin analogues cagrilintide randomised trial amylin analogues effect size Second pass at: Reading a combination trial: attributing effect to components — setting out what I have, and where I think it stops being reliable. I have seen SURMOUNT-2 ( Lancet , 2023) cited in support of…	+39	43	7.3k	12mo
Coming back to: Nausea profile of amylin analogues compared with GLP-1 agonists Compounds › Cagrilintide & amylin analogues effect size cagrilintide cagrisema amylin analogues Posting this under the heading it deserves: Nausea profile of amylin analogues compared with GLP-1 agonists Everything below is what sits behind that. Comparing SCALE ( N Engl J Med , 2015) with FLOW ( N Engl…	+48	53	31k	13mo
Amylin analogue mechanism: satiety signalling separate from GLP-1 Compounds › Cagrilintide & amylin analogues effect size randomised trial cagrilintide cagrisema Solved Amylin analogue mechanism: satiety signalling separate from GLP-1 — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SCALE ( N Engl J Med , 2015) and…	+128	142	38k	13mo
The CagriSema phase 2 paper and what a fixed combination buys — the long version Compounds › Cagrilintide & amylin analogues amylin analogues cagrisema cagrilintide The CagriSema phase 2 paper and what a fixed combination buys — the long version Writing it up because I had to work it out twice and would rather nobody else did. I have seen STEP 1 ( N Engl J Med , 2021)…	+137	158	17k	13mo
Follow-up: Is "synergy" the right word for the combination data? Compounds › Cagrilintide & amylin analogues cagrilintide cagrisema amylin analogues effect size Solved Under review Is "synergy" the right word for the combination data? I have a specific reason for asking rather than idle curiosity, and the context is below. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a…		2	41k	14mo
Second pass at: Historical amylin analogues and what happened to them Compounds › Cagrilintide & amylin analogues amylin analogues effect size cagrilintide cagrisema Closed Second pass at: Historical amylin analogues and what happened to them — setting out what I have, and where I think it stops being reliable. I have seen FLOW ( N Engl J Med , 2024) cited in support of a claim…	+15	19	22k	18mo

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