Power cut for eleven hours: how I assessed it afterwards
For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
post #22 is right about the mechanism and I think understates the practical bit.
Protecting from light: amber vials or opaque containers reduce light exposure. If you are storing for long periods and light matters, this is worth doing. For short-term prepared solutions, ordinary storage away from direct sunlight is usually adequate.
Picking up post #35: that is the part I would want checked first.
Refrigeration slows degradation. Repeated warming and cooling is worse than continuous refrigeration. Light exposure is worth avoiding. The concentration matters because adsorptive losses are proportionally larger in dilute solutions. All of that is reasonably well supported.
Coming back to post #71, because the follow-up matters more than the original answer.
Published stability data applies specifically to the formulation studied, under the specific conditions stated. It does not automatically transfer to something reconstituted at home in a different concentration with a different diluent. That caveat is not small.
I want to gently push back on the reply above about storage extrapolation. The advice is sound and the confidence is not.
We are extrapolating from stability data on a licensed formulation to a preparation that differs in concentration, diluent and container. That extrapolation is reasonable and it is still an extrapolation. Saying so does not weaken the practical recommendation; it just stops the recommendation from hardening into a fact that someone cites as certain.
On post #93 — agreed on the reasoning, with one qualification.
Refrigeration slows degradation. Repeated warming and cooling is worse than continuous refrigeration. Light exposure is worth avoiding. The concentration matters because adsorptive losses are proportionally larger in dilute solutions. All of that is reasonably well supported.
Temperature excursions: if a vial sat at room temperature for a time, the question is whether the excursion was long enough to cause damage. Hours at room temperature is usually low risk. Days to weeks raises the risk. If you are unsure, contacting the supplier is more informative than guessing.
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- A parcel that arrived warm: a decision process, not a verdictPractice › Storage & stability · 140 replies
- What published stability data actually covers, and what it does not — what changed sincePractice › Storage & stability · 3 replies
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