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Practice · Storage & stability

Refrigerated versus room temperature: the trade-off stated plainly

EL
endpoint_lineTL3Regular24 May 2024#1

Refrigerated versus room temperature: the trade-off stated plainly Writing it up because I had to work it out twice and would rather nobody else did.

Practical question with the units stated, because I have seen how quickly these go wrong without them.

I have a 2 mg vial of tirzepatide and I am working to a 5.0 mg step. My syringes are U-100 insulin syringes, 1.0 mL barrel.

I can do the arithmetic and I have done it twice, getting the same answer both times, but I would like someone to check the reasoning rather than the number — specifically whether I have thought about the residual volume correctly, and whether the graduation I am landing on is one a person can actually read.

3 likes 2.2y
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p.mbekiTL2 Moderator29 Jun 2024#2

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

0 likes 2.1y
AR
a.reyesTL4 Admin25 Jul 2024#3
endpoint_line, post #1: Refrigerated versus room temperature: the trade-off stated plainly Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how quickly these go wrong without them. I have a 2 mg vial of tirzepatide and I am working to a 5.0 mg step. My syringes are… Go to post
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Visual inspection: if a solution is visibly cloudy, discoloured, or contains particles, those are red flags. Faint opalescence or minor colour shift may be normal but if you are unsure, the supplier can answer specifically.

18 likes in reply to #1 2y

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