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Topic summary

Second pass at: Fasting versus non-fasting and which tests care

This is a generated summary. It shows the 5 most-liked posts from a topic of 26, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
BI
blank_injectionTL2Analytical chemist16 Dec 2025#3
s.antonsen, post #2: I read the opening post twice before replying, because I had assumed the opposite. Renal function markers: eGFR is estimated, not measured. It depends on creatinine, age, and weight. A small change in creatinine might not mean a real change in kidney function. Go to post

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

27 likes in reply to #2 7mo
ZC
z.cardosoTL2 Moderator5 Jan 2026#6
n.villalobos, post #4: HbA1c and glucose: HbA1c reflects average glucose over months; a spot glucose measurement reflects the moment. Trending glucose downward while HbA1c stays flat is a different picture than glucose going up with HbA1c. Go to post

Coming back to post #4, because the follow-up matters more than the original answer.

Fasting state: some lab tests require fasting; others do not. Lipids on a fasting draw differ from lipids on a fed draw. Always note whether the test was fasting when comparing results.

19 likes in reply to #4 7mo
F
FFaulknerTL3Regular28 Jan 2026#10
d.moreau, post #5: Time of day: some biomarkers vary across the day. Cortisol in the morning differs from cortisol in the evening. Comparing results from different times of day is comparing things that are not the same. Go to post

Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing.

The correction was fair and I had been repeating something I had not checked carefully enough.

26 likes in reply to #5 6mo
DS
d.szymanskiTL3Wiki editor13 Feb 2026#13

I read post #11 twice before replying, because I had assumed the opposite.

Reference intervals: constructed to contain the central 95% of a reference population, which means one in twenty healthy people falls outside one by definition. Add biological variation and analytical imprecision and the base rate of a meaningless flag is substantial.

23 likes 5mo
GT
g.tanakaTL3Regular7 Apr 2026#24

Coming back to post #22, because the follow-up matters more than the original answer.

Liver enzymes: elevation does not specify cause. ALT and AST can rise from many things. Bilirubin helps narrow down the cause. Multiple markers together are more informative than one alone.

30 likes 4mo

Read the full topic (26 posts)

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