Topic summary

Signs of dehydration worth acting on

Safety › Adverse events gallbladder delayed gastric emptying pancreatitis vomiting Solved

This is a generated summary. It shows the 6 most-liked posts from a topic of 39, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

t.ndiayeTL2 Moderator28 Jul 2024#1

Signs of dehydration worth acting on — setting out what I have, and where I think it stops being reliable.

Asking about a population rather than about a person.

The published trials in this class mostly enrolled a fairly specific group, and the questions here frequently come from people well outside it. I would like to understand what the honest position is when someone falls outside the studied population: not "it is fine" and not "there is no data", but what the reasoning actually looks like.

42 likes 2y

IsaksenTL3Regular Solution14 Aug 2024#5

Where to report: in many countries there is a pharmacovigilance system where adverse events can be reported. FDA MedWatch in the US, Yellow Card in UK, EudraVigilance in EU.

31 likes 23mo

s.lundgrenTL2 Moderator3 Sep 2024#12

Medullary thyroid carcinoma is the reason these compounds are contraindicated in people with personal or family history of MTC or multiple endocrine neoplasia type 2. Rodent toxicology showed a signal; human evidence of causation is absent but caution is appropriate.

26 likes 23mo

h.lindqvistTL2 Moderator11 Oct 2024#28

Pancreatitis is a genuine serious adverse event to know: severe epigastric pain, back pain, elevated lipase (≥3× upper limit of normal). If this constellation appears, stopping the drug and seeking urgent evaluation is appropriate.

28 likes 22mo

ch.correiaTL2 Moderator26 Oct 2024 · edited#35

post #34 is right about the mechanism and I think understates the practical bit.

Reporting to regulatory agencies: if you have had a serious event, reporting it to the regulatory agency in your country can help with signal detection across the population.

24 likes 21mo

s.lindqvistTL2 Moderator3 Nov 2024#39

Allergic reactions: true allergy (anaphylaxis, severe rash) is rare with these peptide compounds but possible. Distinguishing true allergy from GI intolerance matters.

32 likes 21mo

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About the Adverse events categorySafety › Adverse events · 6 replies

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