Topic summary

An emergency department visit, described afterwards

Safety › Adverse events gallbladder hypoglycaemia pancreatitis

This is a generated summary. It shows the 9 most-liked posts from a topic of 63, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

g.haalandTL3Regular5 Mar 2025#2

Acute kidney injury: rare but reported. Symptoms (decreased urine output, creatinine elevation) warrant urgent evaluation. Severe dehydration during weight loss is a risk factor.

24 likes 17mo

OTeixeiraTL3Regular25 Mar 2025#6

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

32 likes 16mo

j.nwosuTL2 Moderator6 Apr 2025#9

g.haaland, post #2: Acute kidney injury: rare but reported. Symptoms (decreased urine output, creatinine elevation) warrant urgent evaluation. Severe dehydration during weight loss is a risk factor. Go to post

On post #5 — agreed on the reasoning, with one qualification.

Medullary thyroid carcinoma is the reason these compounds are contraindicated in people with personal or family history of MTC or multiple endocrine neoplasia type 2. Rodent toxicology showed a signal; human evidence of causation is absent but caution is appropriate.

25 likes in reply to #2 16mo

j.sandvikTL2 Moderator27 Apr 2025#15

post #14 answers the question as asked. The question underneath it is different.

Acute kidney injury: rare but reported. Symptoms (decreased urine output, creatinine elevation) warrant urgent evaluation. Severe dehydration during weight loss is a risk factor.

29 likes 15mo

a.salcedoTL3Regular16 May 2025#21

ca.haddad, post #3: Coming back to the opening post, because the follow-up matters more than the original answer. Psychological adverse events: mood changes, anxiety, or suicidal ideation warrant discussion with a mental health professional. These are rare but real. Go to post

Two things before anyone answers the substance.

First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound.

29 likes in reply to #3 14mo

k.karlsenTL2 Moderator7 Jul 2025#39

Reporting to regulatory agencies: if you have had a serious event, reporting it to the regulatory agency in your country can help with signal detection across the population.

23 likes 13mo

s.poulsenTL3Regular30 Jul 2025#48

Pancreatitis is a genuine serious adverse event to know: severe epigastric pain, back pain, elevated lipase (≥3× upper limit of normal). If this constellation appears, stopping the drug and seeking urgent evaluation is appropriate.

24 likes 12mo

r.sobczakTL2 Moderator17 Aug 2025#55

k.karlsen, post #39: Reporting to regulatory agencies: if you have had a serious event, reporting it to the regulatory agency in your country can help with signal detection across the population. Go to post

Acute kidney injury: rare but reported. Symptoms (decreased urine output, creatinine elevation) warrant urgent evaluation. Severe dehydration during weight loss is a risk factor.

28 likes in reply to #39 11mo

g.pemberton_ukTL3Regional · UK1 Sep 2025#61

Where to report: in many countries there is a pharmacovigilance system where adverse events can be reported. FDA MedWatch in the US, Yellow Card in UK, EudraVigilance in EU.

31 likes 11mo

Read the full topic (63 posts)

This topic was referenced in

Where to report an adverse event officially, by regionSafety › Adverse events · 2 replies

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