Picking up the opening post: that is the part I would want checked first.
For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Picking up the opening post: that is the part I would want checked first.
For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
Why "add 2 mL" is not an instruction: the powder in the vial takes up space. "Add 2 mL to a 10 mL vial" and "add 2 mL of diluent so the final volume is approximately 2 mL" are different instructions. Stating the final target volume is clearer than stating the diluent added.
Choosing a concentration on purpose rather than by accident: starting with "I want to draw 0.5 mL per dose" and working backward to the required concentration is more efficient than picking a diluent volume and hoping the math works out. State your target volume, then the required concentration follows.
This follows post #3 rather than contradicting it.
Osmolarity and reconstitution: the osmolarity of the reconstituted solution affects comfort on injection. Isotonic solutions (close to blood osmolarity) are less irritating than hypertonic solutions. This is why diluent choice (sterile water vs. saline) matters.
Over-dilution: if your target dose is 0.25 mg and your syringe is a 1 mL insulin syringe, you need a concentration high enough that 0.25 mg fits on the scale. A 0.25 mg/mL solution requires drawing the entire 1 mL syringe — not readable. A 5 mg/mL solution requires drawing 50 μL — also not practical on an insulin syringe.
Read the full topic (13 posts)
| Topic | Participants | Replies | Views | Activity |
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Reconstituting a multi-strength kit without mixing yourself up — what changed since
On the subject in the title: Reconstituting a multi-strength kit without mixing yourself up — what changed since Working notes rather than a conclusion. Practical question with the units stated, because I…
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+42 | 46 | 1k | 7h |
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Over-dilution: when your dose falls below one readable graduation
On the subject in the title: Over-dilution: when your dose falls below one readable graduation Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am…
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+15 | 19 | 248 | 15mo |
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Coming back to: Checking someone else's arithmetic: a worked example thread
Posting this under the heading it deserves: Checking someone else's arithmetic: a worked example thread Everything below is what sits behind that. Practical question with the units stated, because I have seen…
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+13 | 17 | 293 | 11mo |
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Coming back to: Reconstitution volumes that produce round numbers, tabulated
On the subject in the title: Reconstitution volumes that produce round numbers, tabulated Working notes rather than a conclusion. Practical question with the units stated, because I have seen how quickly…
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2 | 24k | 6mo | |
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Follow-up: The decimal-point error, and the habit that catches it
On the subject in the title: The decimal-point error, and the habit that catches it Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am asking…
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+118 | 131 | 50k | 7mo |
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Pre-registering a personal experiment, seriously
Pre-registering a personal experiment, seriously — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SUSTAIN 6 ( N Engl J Med , 2016) and finding the…
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+96 | 119 | 58k | 14mo |
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Choosing a concentration on purpose rather than by accident
On the subject in the title: Choosing a concentration on purpose rather than by accident Working notes rather than a conclusion. Reporting something rather than asking about it, in case the pattern is useful…
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2 | 719 | 1mo | |
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Fixed versus detachable needles: the trade-offs — does this still hold?
Fixed versus detachable needles: the trade-offs — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. A question about technique rather than about…
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+8 | 12 | 39k | 15h |
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Foaming during reconstitution and whether it matters — the long version
Foaming during reconstitution and whether it matters — the long version — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the…
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+100 | 117 | 6k | 3mo |
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Revisiting: Drawing from a pen cartridge with a syringe: how the risk profile changes
Revisiting: Drawing from a pen cartridge with a syringe: how the risk profile changes Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this…
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2 | 18k | 6h |