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Devices · Syringes & needles · continued

Dead volume across syringe and needle combinations posts 31–60

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

BJ
b.jankowiakTL3Regular29 Nov 2025 · edited#31

I read post #29 twice before replying, because I had assumed the opposite.

Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing.

The correction was fair and I had been repeating something I had not checked carefully enough.

24 likes 8mo
JF
j.falkTL2 Moderator2 Dec 2025#32

This follows post #29 rather than contradicting it.

Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if you have abdominal adiposity.

11 likes 8mo
YM
y.mensahTL3Wiki editor4 Dec 2025#33

Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose.

3 likes 8mo
HE
h.espinozaTL2 Moderator6 Dec 2025#34
j.falk, post #5: Picking up post #2: that is the part I would want checked first. Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error. Go to post

Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it matters if precision matters.

0 likes in reply to #5 8mo
BS
buffer_sheetTL3Regular8 Dec 2025#35
ppm_error, post #25: Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it matters if precision matters. Go to post

Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm your syringe is U-100. Confusion between insulin units and milligrams is the most common syringe error.

32 likes in reply to #25 8mo
BW
b.wikstromTL2 Moderator10 Dec 2025#36

Picking up post #33: that is the part I would want checked first.

Sharps disposal: needles and syringes should be disposed in a sharps container (a rigid, puncture-resistant container). Do not put them in regular trash. Many pharmacies accept filled sharps containers.

16 likes 8mo
BE
bench_entryTL3Regular12 Dec 2025#37

Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice.

6 likes 8mo
IW
i.wojcikTL2 Moderator14 Dec 2025#38
c.okafor, post #2: Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less. Go to post

For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.

1 like in reply to #2 7mo
ED
e.dalgleishTL3Regular16 Dec 2025#39

Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if you have abdominal adiposity.

12 likes 7mo
SS
s.salgadoTL2 Moderator18 Dec 2025#40

Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.

4 likes 7mo
RB
r.bruunTL2 Moderator20 Dec 2025#41
n.cardoso, post #28: Fixed versus detachable needles: insulin syringes usually have fixed needles (no dead volume loss to the hub). Luer-lock syringes use detachable needles (more dead volume). Fixed needles are preferred for small doses. Go to post

Picking up post #38: that is the part I would want checked first.

Fixed versus detachable needles: insulin syringes usually have fixed needles (no dead volume loss to the hub). Luer-lock syringes use detachable needles (more dead volume). Fixed needles are preferred for small doses.

31 likes in reply to #28 7mo
HO
h.oyelowoTL2Regular22 Dec 2025#42
i.wojcik, post #38: For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use. Go to post

Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error.

0 likes in reply to #38 7mo
CC
ch.correiaTL2 Moderator24 Dec 2025#43

Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose.

6 likes 7mo
SC
sourced_claimsTL3Regular26 Dec 2025#44

Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if you have abdominal adiposity.

16 likes 7mo
JB
j.bhattacharyaTL2 Moderator27 Dec 2025 · edited#45

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

23 likes 7mo
QL
quiet_lurkerTL2Regular29 Dec 2025#46
excursion_check, post #1: On the subject in the title: Dead volume across syringe and needle combinations Working notes rather than a conclusion. Practical question with the units stated, because I have seen how quickly these go wrong without them. I have a 15 mg vial of semaglutide and I am working to a 1.0 mg step. My syringes are U-100 insulin syringes, 1.0… Go to post

Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it matters if precision matters.

0 likes in reply to #1 7mo
MR
m.radichTL2 Moderator31 Dec 2025#47

Sharps disposal: needles and syringes should be disposed in a sharps container (a rigid, puncture-resistant container). Do not put them in regular trash. Many pharmacies accept filled sharps containers.

3 likes 7mo
SC
s.chowdhuryTL3Regular2 Jan 2026#48

Worth separating two things that post #44 runs together.

Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm your syringe is U-100. Confusion between insulin units and milligrams is the most common syringe error.

10 likes 7mo
GB
g.bakkenTL2 Moderator4 Jan 2026#49

Fixed versus detachable needles: insulin syringes usually have fixed needles (no dead volume loss to the hub). Luer-lock syringes use detachable needles (more dead volume). Fixed needles are preferred for small doses.

16 likes 7mo
ST
sterile_tableTL3Regular6 Jan 2026#50
buffer_sheet, post #35: Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm your syringe is U-100. Confusion between insulin units and milligrams is the most common syringe error. Go to post

Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error.

32 likes in reply to #35 7mo
TV
t.vargaTL2 Moderator8 Jan 2026 · edited#51

Two things before anyone answers the substance.

First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound.

5 likes 7mo
MD
methods_draftTL2Member10 Jan 2026#52

post #51 answers the question as asked. The question underneath it is different.

Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.

0 likes 7mo
BW
br.wikstromTL2 Moderator12 Jan 2026#53

Coming back to post #51, because the follow-up matters more than the original answer.

Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice.

28 likes 6mo
GR
gradient_reviewTL2Member13 Jan 2026#54
h.oyelowo, post #42: Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error. Go to post

Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose.

14 likes in reply to #42 6mo
AZ
an.zamoraTL2 Moderator15 Jan 2026#55

Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice.

8 likes 6mo
R
RodriguesTL3Regular17 Jan 2026#56

Reading units correctly: look at the marking from the side, not from above or below. The bottom of the plunger tip is the reading. Parallax error (wrong angle) is a source of dosing error.

2 likes 6mo
KO
k.ogunleyeTL2 Moderator19 Jan 2026#57
t.varga, post #51: Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound. Go to post

I read post #55 twice before replying, because I had assumed the opposite.

Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm your syringe is U-100. Confusion between insulin units and milligrams is the most common syringe error.

0 likes in reply to #51 6mo
S
SHermansenTL221 Jan 2026#58
RN
r.novakTL2 Moderator23 Jan 2026#59

Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if you have abdominal adiposity.

0 likes 6mo
OA
o.abrahamsenTL3Regular24 Jan 2026#60

Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.

0 likes 6mo