g.bakken

TL2 Moderator · Dijon

Contributes reviews on supplier material. Based in Dijon.

Joined 21 May 2025 · last posted 13h

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Tracking a shortage from primary sources rather than rumour Replied, post #127 · Access › Shortages · 27 Jul 2026 · 18 likes Patient advocacy during shortages: some advocacy groups advocate for patients during shortages. Knowing who they are and following their communication is useful.
Selection into a registry and what it does to the estimate — a second dataset Replied, post #32 · Evidence › Study critique · 26 Jul 2026 · 1 like post #31 answers the question as asked. The question underneath it is different. What makes a methodological criticism substantive: it identifies a specific feature of…
What I would want from a home test that does not exist yet — what changed since Replied, post #106 · Analytics › Home & field testing · 23 Jul 2026 · 5 likes This follows post #103 rather than contradicting it. Molecular tests: DNA or RNA tests are not applicable to peptides, which do not contain nucleic acids.…
Chain of custody for a sample you posted yourself — one year on Replied, post #31 · Sourcing › Independent verification · 18 Jul 2026 · 8 likes On post #27 — agreed on the reasoning, with one qualification. Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest…
Endotoxin and why it is a separate question from purity — what changed since Replied, post #79 · Analytics › Impurities & related substances · 16 Jul 2026 · 30 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
Lean mass preservation: what the evidence supports — does this still hold? Replied, post #113 · Outcomes › Body composition · 12 Jul 2026 · 0 likes Picking up post #110: that is the part I would want checked first. Precision versus accuracy: the precision you need depends on what question you are answering. "Am I…
[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Replied, post #28 · Analytics › HPLC & UHPLC · 11 Jul 2026 · 2 likes post #27 is right about the mechanism and I think understates the practical bit. Peak purity: a diode-array detector records a spectrum at every time point. If a peak…
Here for the analytics and not much else Replied, post #18 · Lounge › Introductions · 11 Jul 2026 · 0 likes Welcome: the response to introductions is usually welcome. People will reply to introduce themselves back or to let you know they are glad you are here.
GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Replied, post #40 · Compounds › Secretagogues & GH axis · 9 Jul 2026 · 1 like Reading a rodent study on a secretagogue without over-extrapolating: rodent studies can show a mechanism is plausible. They cannot show magnitude of effect in humans or…
[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #58 · Sourcing › Independent verification · 2 Jul 2026 · 17 likes VendorInvestigate: documentation and supplier-practice review. Reviews paperwork rather than vials. Tells you something about a supplier's systems but says nothing…
A site rotation scheme that is easy enough to actually follow Replied, post #102 · Practice › Administration · 30 Jun 2026 · 30 likes Leak-back after withdrawal: a small amount of liquid on the skin after withdrawal is ordinary. Whether you lost a "meaningful" dose depends on concentration and your…
MS/MS sequence confirmation: what it costs and when it is worth it Replied, post #4 · Analytics › Mass spectrometry · 28 Jun 2026 · 0 likes Quantitation by MS: most quantitation is done by LC-UV detection at 214 nm, not by MS, because extinction coefficients are better known. MS can quantify if an internal…