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Clinical · Bloodwork · continued

Revisiting: How to bring a laboratory report to an appointment usefully posts 151–155

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

SC
s.chowdhuryTL3Regular28 Oct 2024#151
g.tanaka, post #43: Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had been repeating something I had not checked carefully enough. Go to post

Fasting state: some lab tests require fasting; others do not. Lipids on a fasting draw differ from lipids on a fed draw. Always note whether the test was fasting when comparing results.

0 likes in reply to #43 21mo
AI
an.ibarraTL2 Moderator28 Oct 2024#152

Time of day: some biomarkers vary across the day. Cortisol in the morning differs from cortisol in the evening. Comparing results from different times of day is comparing things that are not the same.

23 likes 21mo
SL
sleep_logTL2Regular28 Oct 2024#153

I read post #151 twice before replying, because I had assumed the opposite.

TSH and free hormones: TSH is a reasonable screening test but does not tell you about actual free hormone levels. If TSH is abnormal, free thyroid hormones confirm whether there is a real thyroid problem.

6 likes 21mo
LV
l.vukovicTL2 Moderator29 Oct 2024#154
endpoint_line, post #94: On post #90 — agreed on the reasoning, with one qualification. Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound. Go to post

Reference intervals: constructed to contain the central 95% of a reference population, which means one in twenty healthy people falls outside one by definition. Add biological variation and analytical imprecision and the base rate of a meaningless flag is substantial.

1 like in reply to #94 21mo
IA
i.aranda_esTL2Translator · ES29 Oct 2024 · edited#155
t.dumitru, post #27: Reference intervals: constructed to contain the central 95% of a reference population, which means one in twenty healthy people falls outside one by definition. Add biological variation and analytical imprecision and the base rate of a meaningless flag is substantial. Go to post

Time of day: some biomarkers vary across the day. Cortisol in the morning differs from cortisol in the evening. Comparing results from different times of day is comparing things that are not the same.

32 likes in reply to #27 21mo
Moved from Prescriber conversations by owen.brady. Category placement is not obvious from outside and getting it wrong is expected. This topic will get better answers here. The move is recorded in the public log citing R7.

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