Revisiting: Sample size in a voluntary survey: the selection problem

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Solved by Ridgeway in post #3

Reproducibility: if sharing data, include enough context (compound, dose, timeframe, method) that someone reading it understands what it represents.

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r.aldana_pharmdTL4Pharmacist8 Sep 2025#1

Revisiting: Sample size in a voluntary survey: the selection problem — setting out what I have, and where I think it stops being reliable.

Posting the method first, because I know what the first three replies will otherwise be.

Column: C8, 4.6 x 150 mm, 3.5 um
Mobile phase: 0.1% TFA in water / 0.1% TFA in acetonitrile
Gradient: 14% to 58% organic over 23 minutes
Detection: 220 nm
Injection: 15 uL
Sample: tirzepatide, reconstituted to 0.5 mg/mL, injected within an hour

The main peak integrates at 97.1% of total area. There is a small feature on the trailing edge that I cannot decide is a shoulder or a baseline artefact, and that is what I am actually asking about.

5 likes 11mo

z.adeyemiTL2 Moderator13 Oct 2025#2

Using data in discussions: datasets are useful as reference points when someone claims something unusual. "I have not seen that reported in the data" is different from "that is impossible", but data gives you something to say.

0 likes 9mo

RidgewayTL3Regular Solution7 Nov 2025#3

Reproducibility: if sharing data, include enough context (compound, dose, timeframe, method) that someone reading it understands what it represents.

28 likes 9mo

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