n.duarte

TL2 Moderator · Osaka

Contributes reviews on supplier material. Based in Osaka.

Joined 18 September 2024 · last posted 3d

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Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #75 · Evidence › Journal club · 25 Jul 2026 · 27 likes SURPASS-2 (N Engl J Med 2021): Direct comparison of tirzepatide with semaglutide 1.0 mg. The 1.0 mg dose is not the highest available, which is the central and…
Impurity thresholds: where the common numbers come from Replied, post #12 · Analytics › Impurities & related substances · 22 Jul 2026 · 0 likes Truncation products: fragments from incomplete synthesis or from degradation. They elute quite differently from the intact peptide because they are much smaller and…
Pinch or no pinch, and how needle length changes the answer — what changed since Replied, post #60 · Practice › Administration · 21 Jul 2026 · 15 likes Drawing up with one needle and injecting with another: a reasonable practice if you have extra needles. Fresh needle for injection reduces tissue drag and can decrease…
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #94 · Evidence › Journal club · 10 Jul 2026 · 3 likes On post #90 — agreed on the reasoning, with one qualification. STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most…
Revisiting: What pooling buys you and what it destroys Replied, post #85 · Evidence › Meta-analyses · 9 Jul 2026 · 1 like Funnel plots: a plot of study effect size versus sample size that helps detect publication bias. If small studies are missing on the negative side, the funnel is…
Follow-up: Sleep quality changes during weight loss Replied, post #57 · Wellbeing › Sleep · 29 Jun 2026 · 0 likes Coming back to post #55, because the follow-up matters more than the original answer. Practical note that does not fit anywhere else. Whatever you conclude from this…
[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #49 · Sourcing › Independent verification · 28 Jun 2026 · 7 likes This follows post #46 rather than contradicting it. I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The…
Spreadsheets: an appreciation — what changed since Replied, post #78 · Lounge › Off topic · 22 Jun 2026 · 7 likes I read post #76 twice before replying, because I had assumed the opposite. Science communication: if you come across an interesting science paper or article about…
Second pass at: Programming during a large energy deficit Replied, post #31 · Nutrition & Training › Resistance training · 17 Jun 2026 · 17 likes Programming while losing weight quickly: realistic expectations are crucial. Strength often stays surprisingly stable; power output might decline slightly. Expecting…
An appeal that succeeded, with the letter structure — the long version Replied, post #78 · Access › Insurance & coverage · 10 Jun 2026 · 32 likes Prior authorisation: pre-approval requirements and how to satisfy them. Most denials cite specific criteria. Understanding the criterion is the first step in satisfying…
Risk-of-bias tools and the judgement they conceal — does this still hold? Replied, post #13 · Evidence › Meta-analyses · 7 Jun 2026 · 1 like Study quality and weighting: some meta-analyses weight all studies equally; others weight by study size or study quality. The choice affects the result and should be…
Official shortage notices and what they authorise Replied, post #82 · Access › Shortages · 2 Jun 2026 · 0 likes Allocation and rationing: during severe shortages, suppliers might ration allocation to prescribers. Understanding rationing policies from your prescriber matters for…