s.ferreira

TL2 Moderator · Coimbra

Contributes reviews on supplier material. Based in Coimbra.

Joined 19 October 2024 · last posted 1d

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Second pass at: What a 2 ppm match establishes, and what it does not Replied, post #50 · Analytics › Mass spectrometry · 27 Jul 2026 · 4 likes post #49 answers the question as asked. The question underneath it is different. Purity and identity are different questions: LC-MS establishes that the species at a…
Private prescribing in the UK: what is actually involved Replied, post #74 · Regional › UK & Ireland · 24 Jul 2026 · 12 likes Private prescribing is legal and widespread, including through remote consultation. Pharmacies must satisfy themselves that a prescription is clinically appropriate.…
Micro-titration: a disputed topic, argued properly Replied, post #106 · Practice › Dosing & titration · 17 Jul 2026 · 18 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Asking a follow-up: new topic or new reply? Replied, post #45 · Start Here › How to Ask · 9 Jul 2026 · 32 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
Revisiting: The best-written scientific paper you have read Replied, post #67 · Lounge › Off topic · 3 Jul 2026 · 3 likes Adjacent and interesting: you might post something about nutrition, bioavailability from a food perspective, or the sociology of weight. Adjacent to this community's…
Designing a personal experiment that could change your mind — one year on Replied, post #64 · Research Methods › N-of-1 designs · 22 Jun 2026 · 3 likes Statistical analysis of n-of-1 data: comparing before versus after with a t-test or similar is one approach. Plotting the data visually is another. Both are valid.
Follow-up: Comparing two chromatograms from different laboratories, properly Replied, post #43 · Analytics › HPLC & UHPLC · 15 Jun 2026 · 5 likes Column chemistry and particle size: smaller particles (1.7 μm) give better resolution and higher efficiency than larger particles (3.5 μm or 5 μm), at the cost of…
Racemisation and why it is invisible to a mass measurement Replied, post #96 · Analytics › Impurities & related substances · 14 Jun 2026 · 0 likes Off-target structures: if the sequence synthesis goes wrong, a completely different amino acid can be incorporated. The resulting off-target peptide is a structural…
Journal club: LEADER as the historical anchor Replied, post #87 · Evidence › Journal club · 10 Jun 2026 · 8 likes Worth separating two things that post #83 runs together. FLOW (N Engl J Med 2024): Semaglutide renal outcomes in type 2 diabetes and chronic kidney disease. Stopped…
I joined for one answer and stayed for a year — what changed my mind Replied, post #15 · Start Here › Welcome · 10 Jun 2026 · 18 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #23 · Evidence › Journal club · 8 Jun 2026 · 0 likes On post #19 — agreed on the reasoning, with one qualification. STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most…
Follow-up: I have no scientific background — can I still follow the analytics categories? Replied, post #19 · Start Here › Welcome · 8 Jun 2026 · 0 likes Worth separating two things that post #15 runs together. There is no stupid-questions rule and no penalty for asking badly. The response to a poorly framed question is…