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Wellbeing · Mental health · continued

Anxiety in the first weeks: drug, situation, or both — what changed since posts 61–90

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

LG
lc_gradientTL3Analytical chemist10 Dec 2025#61

Worth separating two things that post #57 runs together.

Sleep and mental health: these compounds can affect sleep for some people. Sleep deprivation worsens mood and anxiety. Addressing sleep separately from mood matters.

2 likes 8mo
RZ
r.zielinskiTL2 Moderator13 Dec 2025#62
quiet_lurker, post #60: On post #56 — agreed on the reasoning, with one qualification. Substance use: if someone has a history of substance use, appetite suppression and weight loss can shift thinking about body and substance use. This is a risk factor worth acknowledging. Go to post

Support and community: some people process weight change through community (online or in-person). Others prefer privacy. Knowing what you need and seeking it proactively helps.

0 likes in reply to #60 7mo
DB
dr_bhattacharyaTL3Physician15 Dec 2025#63

Two things before anyone answers the substance.

First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound.

27 likes 7mo
DV
d.vukovicTL2 Moderator17 Dec 2025 · edited#64

Disordered eating history: a history of anorexia, bulimia, or other eating disorders changes the risk-benefit calculation. Appetite suppression might trigger relapse. Specialist input is prudent.

13 likes 7mo
MD
m.dalgaardTL3Regular19 Dec 2025#65
PharmNotes_Whitfield, post #7: I read post #5 twice before replying, because I had assumed the opposite. Substance use: if someone has a history of substance use, appetite suppression and weight loss can shift thinking about body and substance use. This is a risk factor worth acknowledging. Go to post

On post #61 — agreed on the reasoning, with one qualification.

Mood and anxiety: mood changes and anxiety are reported by some people. Baseline mental health status matters for risk. Someone with a history of depression should plan closer monitoring.

0 likes in reply to #7 7mo
RM
r.mensaTL2 Moderator22 Dec 2025#66
m.radich, post #57: This follows post #54 rather than contradicting it. Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the kind that comes from remembering a figure instead of looking it up. Go to post

post #65 answers the question as asked. The question underneath it is different.

For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.

0 likes in reply to #57 7mo
TD
titration_diaryTL3Regular24 Dec 2025#67

Substance use: if someone has a history of substance use, appetite suppression and weight loss can shift thinking about body and substance use. This is a risk factor worth acknowledging.

19 likes 7mo
AJ
a.jansenTL2 Moderator26 Dec 2025#68

Sleep and mental health: these compounds can affect sleep for some people. Sleep deprivation worsens mood and anxiety. Addressing sleep separately from mood matters.

8 likes 7mo
PM
p.marchettiTL2 Moderator28 Dec 2025#69
a.jansen, post #68: Sleep and mental health: these compounds can affect sleep for some people. Sleep deprivation worsens mood and anxiety. Addressing sleep separately from mood matters. Go to post

Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive.

8 likes in reply to #68 7mo
DB
d.bakkerTL2 Moderator31 Dec 2025#70

post #69 is right about the mechanism and I think understates the practical bit.

When to involve a professional: if mood changes are persistent, deepen over weeks, or interfere with function, involving a mental health professional is appropriate. These are not trivialities to ignore.

2 likes 7mo
AH
a.hartmannTL2 Moderator2 Jan 2026#71
endpoint_line, post #12: Identity and self-image: for some people, weight and body size are central to identity. Large change to body size can affect identity. This is not pathological; it is human. Go to post

Body image and weight loss: large weight loss changes a person's relationship with their body in ways that can be psychologically complex. Some of that is positive; some might involve adjustment or processing.

5 likes in reply to #12 7mo
BM
buffer_marginTL34 Jan 2026#72
SV
s.vanheckeTL2 Moderator6 Jan 2026#73

post #72 is right about the mechanism and I think understates the practical bit.

Identity and self-image: for some people, weight and body size are central to identity. Large change to body size can affect identity. This is not pathological; it is human.

28 likes 7mo
EC
excursion_checkTL3Regular8 Jan 2026#74

Motivation and expectation: starting with clear motivation and realistic expectations about what will happen and when helps with psychological adjustment.

0 likes 7mo
TV
t.verhoevenTL2 Moderator11 Jan 2026#75
gradient_file, post #21: Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive. Go to post

Picking up post #72: that is the part I would want checked first.

For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.

2 likes in reply to #21 7mo
TT
taper_tableTL3Regular13 Jan 2026 · edited#76
s.stavrianos, post #38: Mood and anxiety: mood changes and anxiety are reported by some people. Baseline mental health status matters for risk. Someone with a history of depression should plan closer monitoring. Go to post

Coming back to post #74, because the follow-up matters more than the original answer.

Support and community: some people process weight change through community (online or in-person). Others prefer privacy. Knowing what you need and seeking it proactively helps.

9 likes in reply to #38 6mo
EM
e.mensaTL2 Moderator15 Jan 2026#77

Disordered eating history: a history of anorexia, bulimia, or other eating disorders changes the risk-benefit calculation. Appetite suppression might trigger relapse. Specialist input is prudent.

21 likes 6mo
LC
l.chevalierTL3Regular17 Jan 2026#78

When to involve a professional: if mood changes are persistent, deepen over weeks, or interfere with function, involving a mental health professional is appropriate. These are not trivialities to ignore.

0 likes 6mo
BN
b.nilsenTL2 Moderator19 Jan 2026 · edited#79
g.verhoeven, post #30: Support and community: some people process weight change through community (online or in-person). Others prefer privacy. Knowing what you need and seeking it proactively helps. Go to post

This follows post #76 rather than contradicting it.

Body image and weight loss: large weight loss changes a person's relationship with their body in ways that can be psychologically complex. Some of that is positive; some might involve adjustment or processing.

13 likes in reply to #30 6mo
SD
s.dziedzicTL2 Moderator22 Jan 2026#80

Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive.

27 likes 6mo
GR
g.rasmussenTL2 Moderator24 Jan 2026#81
excursion_check, post #74: Motivation and expectation: starting with clear motivation and realistic expectations about what will happen and when helps with psychological adjustment. Go to post

Coming back to post #79, because the follow-up matters more than the original answer.

Mood and anxiety: mood changes and anxiety are reported by some people. Baseline mental health status matters for risk. Someone with a history of depression should plan closer monitoring.

0 likes in reply to #74 6mo
SB
s.bruunTL2 Moderator26 Jan 2026#82

Picking up post #79: that is the part I would want checked first.

For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.

20 likes 6mo
BD
b.demirTL2 Moderator28 Jan 2026#83

Social and relationship impacts: weight change affects how others perceive and interact with a person. Those impacts are real and can be psychologically significant.

5 likes 6mo
HM
h.mensahTL2 Moderator30 Jan 2026#84

Identity and self-image: for some people, weight and body size are central to identity. Large change to body size can affect identity. This is not pathological; it is human.

0 likes 6mo
LP
l.piresTL2 Moderator1 Feb 2026#85
p.marchetti, post #69: Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive. Go to post

Two things before anyone answers the substance.

First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound.

29 likes in reply to #69 6mo
ME
m.ekstromTL2 Moderator3 Feb 2026#86
e.iyer, post #51: Identity and self-image: for some people, weight and body size are central to identity. Large change to body size can affect identity. This is not pathological; it is human. Go to post

This follows post #83 rather than contradicting it.

Motivation and expectation: starting with clear motivation and realistic expectations about what will happen and when helps with psychological adjustment.

14 likes in reply to #51 6mo
ME
m.eriksenTL2 Moderator6 Feb 2026#87

Substance use: if someone has a history of substance use, appetite suppression and weight loss can shift thinking about body and substance use. This is a risk factor worth acknowledging.

2 likes 6mo
HA
h.amankwahTL2 Moderator8 Feb 2026#88

Sleep and mental health: these compounds can affect sleep for some people. Sleep deprivation worsens mood and anxiety. Addressing sleep separately from mood matters.

0 likes 6mo
MV
m.vukovicTL210 Feb 2026#89
NG
np_gilmoreTL3Nurse practitioner12 Feb 2026#90
crossover_review, post #44: I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient. Go to post

Disordered eating history: a history of anorexia, bulimia, or other eating disorders changes the risk-benefit calculation. Appetite suppression might trigger relapse. Specialist input is prudent.

0 likes in reply to #44 5mo