Wellbeing · Mental health

Anxiety in the first weeks: drug, situation, or both — what changed since

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bias_varianceTL4Biostatistician16 Jun 2025#1

Anxiety in the first weeks: drug, situation, or both — what changed since Writing it up because I had to work it out twice and would rather nobody else did.

Asking about a population rather than about a person.

The published trials in this class mostly enrolled a fairly specific group, and the questions here frequently come from people well outside it. I would like to understand what the honest position is when someone falls outside the studied population: not "it is fine" and not "there is no data", but what the reasoning actually looks like.

1 like 13mo

s.mbekiTL2 Moderator24 Jun 2025#2

Disordered eating history: a history of anorexia, bulimia, or other eating disorders changes the risk-benefit calculation. Appetite suppression might trigger relapse. Specialist input is prudent.

0 likes 13mo

dietitian_hollisTL3Dietitian29 Jun 2025#3

s.mbeki, post #2: Disordered eating history: a history of anorexia, bulimia, or other eating disorders changes the risk-benefit calculation. Appetite suppression might trigger relapse. Specialist input is prudent. Go to post

Coming back to the opening post, because the follow-up matters more than the original answer.

Social and relationship impacts: weight change affects how others perceive and interact with a person. Those impacts are real and can be psychologically significant.

2 likes in reply to #2 13mo

h.agyemanTL2 Moderator4 Jul 2025 · edited#4

dietitian_hollis, post #3: Coming back to the opening post, because the follow-up matters more than the original answer. Social and relationship impacts: weight change affects how others perceive and interact with a person. Those impacts are real and can be psychologically significant. Go to post

Picking up post #2: that is the part I would want checked first.

Body image and weight loss: large weight loss changes a person's relationship with their body in ways that can be psychologically complex. Some of that is positive; some might involve adjustment or processing.

4 likes in reply to #3 13mo

bench_notesTL4 Moderator8 Jul 2025#5

Motivation and expectation: starting with clear motivation and realistic expectations about what will happen and when helps with psychological adjustment.

1 like 13mo

v.baptistaTL2 Moderator12 Jul 2025 · edited#6

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

0 likes 13mo

PharmNotes_WhitfieldTL4Pharmacist16 Jul 2025#7

I read post #5 twice before replying, because I had assumed the opposite.

Substance use: if someone has a history of substance use, appetite suppression and weight loss can shift thinking about body and substance use. This is a risk factor worth acknowledging.

18 likes 12mo

s.cabreraTL2 Moderator20 Jul 2025#8

bench_notes, post #5: Motivation and expectation: starting with clear motivation and realistic expectations about what will happen and when helps with psychological adjustment. Go to post

Sleep and mental health: these compounds can affect sleep for some people. Sleep deprivation worsens mood and anxiety. Addressing sleep separately from mood matters.

7 likes in reply to #5 12mo

n.ekstromTL2Regular23 Jul 2025#9

On post #5 — agreed on the reasoning, with one qualification.

Mood and anxiety: mood changes and anxiety are reported by some people. Baseline mental health status matters for risk. Someone with a history of depression should plan closer monitoring.

13 likes in reply to #2 12mo

s.vukovicTL2 Moderator27 Jul 2025#10

post #9 answers the question as asked. The question underneath it is different.

Support and community: some people process weight change through community (online or in-person). Others prefer privacy. Knowing what you need and seeking it proactively helps.

4 likes 12mo

i.dumitruTL2 Moderator30 Jul 2025#11

bench_notes, post #5: Motivation and expectation: starting with clear motivation and realistic expectations about what will happen and when helps with psychological adjustment. Go to post

When to involve a professional: if mood changes are persistent, deepen over weeks, or interfere with function, involving a mental health professional is appropriate. These are not trivialities to ignore.

0 likes in reply to #5 12mo

endpoint_lineTL3Regular3 Aug 2025#12

Identity and self-image: for some people, weight and body size are central to identity. Large change to body size can affect identity. This is not pathological; it is human.

4 likes 12mo

in.guerreroTL2 Moderator6 Aug 2025#13

This follows post #10 rather than contradicting it.

Identity and self-image: for some people, weight and body size are central to identity. Large change to body size can affect identity. This is not pathological; it is human.

18 likes 12mo

h.nicolaidesTL3Regular9 Aug 2025#14

Motivation and expectation: starting with clear motivation and realistic expectations about what will happen and when helps with psychological adjustment.

0 likes 12mo

a.cabreraTL2 Moderator12 Aug 2025#15

bench_notes, post #5: Motivation and expectation: starting with clear motivation and realistic expectations about what will happen and when helps with psychological adjustment. Go to post

Disordered eating history: a history of anorexia, bulimia, or other eating disorders changes the risk-benefit calculation. Appetite suppression might trigger relapse. Specialist input is prudent.

1 like in reply to #5 12mo

CFairweatherTL1Member15 Aug 2025#16

Two things before anyone answers the substance.

First, the context in the first post is clear and specific. Second, the question is framed so that an answer can actually address it. Both are the norm here and both matter more than they sound.

7 likes 11mo

s.demirTL2 Moderator19 Aug 2025#17

Picking up post #14: that is the part I would want checked first.

Support and community: some people process weight change through community (online or in-person). Others prefer privacy. Knowing what you need and seeking it proactively helps.

25 likes 11mo

RidgewayTL3Regular22 Aug 2025#18

s.demir, post #17: Picking up post #14: that is the part I would want checked first. Support and community: some people process weight change through community (online or in-person). Others prefer privacy. Knowing what you need and seeking it proactively helps. Go to post

Coming back to post #16, because the follow-up matters more than the original answer.

Mood and anxiety: mood changes and anxiety are reported by some people. Baseline mental health status matters for risk. Someone with a history of depression should plan closer monitoring.

0 likes in reply to #17 11mo

z.szaboTL2 Moderator25 Aug 2025#19

post #18 is right about the mechanism and I think understates the practical bit.

Sleep and mental health: these compounds can affect sleep for some people. Sleep deprivation worsens mood and anxiety. Addressing sleep separately from mood matters.

4 likes 11mo

k.redgraveTL2Member28 Aug 2025 · edited#20

Worth separating two things that post #16 runs together.

Substance use: if someone has a history of substance use, appetite suppression and weight loss can shift thinking about body and substance use. This is a risk factor worth acknowledging.

12 likes 11mo

gradient_fileTL231 Aug 2025#21

Post hidden by community flags

Staff rationale: Hidden by community flags. The claim about a named supplier was not accompanied by a batch, a date, a method or a document, which R6 requires.

Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive.

The corresponding entry is in the public moderation log. Hidden posts are never deleted.

s.kravchenkoTL2 Moderator2 Sep 2025#22

post #21 answers the question as asked. The question underneath it is different.

18 likes 11mo

WoodhouseTL2Member5 Sep 2025#23

Coming back to post #21, because the follow-up matters more than the original answer.

7 likes 11mo

ca.vermeulenTL2 Moderator8 Sep 2025#24

Social and relationship impacts: weight change affects how others perceive and interact with a person. Those impacts are real and can be psychologically significant.

1 like 11mo

RidgewayTL3Regular11 Sep 2025#25

bias_variance, post #1: Anxiety in the first weeks: drug, situation, or both — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published trials in this class mostly enrolled a fairly specific group, and the questions here frequently come from people… Go to post

Worth separating two things that post #21 runs together.

Substance use: if someone has a history of substance use, appetite suppression and weight loss can shift thinking about body and substance use. This is a risk factor worth acknowledging.

0 likes in reply to #1 11mo

i.grimaldiTL2 Moderator14 Sep 2025#26

k.redgrave, post #20: Worth separating two things that post #16 runs together. Substance use: if someone has a history of substance use, appetite suppression and weight loss can shift thinking about body and substance use. This is a risk factor worth acknowledging. Go to post

post #25 is right about the mechanism and I think understates the practical bit.

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

25 likes in reply to #20 10mo

endpoint_lineTL3Regular17 Sep 2025 · edited#27

Motivation and expectation: starting with clear motivation and realistic expectations about what will happen and when helps with psychological adjustment.

12 likes 10mo

z.adeyemiTL2 Moderator19 Sep 2025#28

Identity and self-image: for some people, weight and body size are central to identity. Large change to body size can affect identity. This is not pathological; it is human.

4 likes 10mo

r.scholtenTL2Member22 Sep 2025#29

On post #25 — agreed on the reasoning, with one qualification.

Sleep and mental health: these compounds can affect sleep for some people. Sleep deprivation worsens mood and anxiety. Addressing sleep separately from mood matters.

19 likes 10mo

g.verhoevenTL2 Moderator25 Sep 2025#30

h.nicolaides, post #14: Motivation and expectation: starting with clear motivation and realistic expectations about what will happen and when helps with psychological adjustment. Go to post

Support and community: some people process weight change through community (online or in-person). Others prefer privacy. Knowing what you need and seeking it proactively helps.

8 likes in reply to #14 10mo

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