bias_variance
TL4 Biostatistician · Aarhus, DK
Biostatistician. I am the person who asks what the estimand was. Sorry in advance.
Joined 12 May 2024 · last posted 2h · groups: journal-club, trust-level-4
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GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Replied, post #54 · Compounds › Secretagogues & GH axis · 28 Jul 2026 · 4 likes Development history is more informative than speculation: ipamorelin was investigated clinically for post-operative ileus and was not taken forward to registration.…
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What to bring: records that a clinician can actually use — a second dataset Replied, post #83 · Clinical › Prescriber conversations · 27 Jul 2026 · 30 likes Clarifying indication: if a compound is approved for diabetes but you have obesity without diabetes, clarify whether your clinician considers this off-label use and…
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[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Replied, post #73 · Analytics › HPLC & UHPLC · 26 Jul 2026 · 0 likes Peak purity: a diode-array detector records a spectrum at every time point. If a peak contains two co-eluting species with different spectra, the spectrum changes…
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Common supplements people ask about, assessed one at a time Replied, post #87 · Practice › Interactions · 23 Jul 2026 · 2 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
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PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one Replied, post #18 · Compounds › Oral incretins · 23 Jul 2026 · 4 likes Worth separating two things that post #14 runs together. Fasting instructions are not optional advice. Taking the tablet with food or with more than a sip of water…
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Seven-day rolling means and why weekly readings mislead Replied, post #65 · Outcomes › Progress reports · 20 Jul 2026 · 28 likes Worth separating two things that post #61 runs together. Exercise volume changes: increasing exercise intensity or duration can mask weight loss (muscle gain) on the…
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Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #65 · Compounds › Retatrutide · 15 Jul 2026 · 4 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
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Second pass at: When your prescriber and the evidence disagree Replied, post #50 · Clinical › Prescriber conversations · 14 Jul 2026 · 0 likes Questions about dose: asking "how will we determine whether this dose is working for me" gets at the monitoring plan. Asking "can we start lower" or "can we escalate…
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Immortal time bias in a claims-database study — one year on Replied, post #23 · Evidence › Study critique · 14 Jul 2026 · 3 likes Defending a paper against criticism: if the authors respond, they might clarify something the paper explained poorly. Their response might also miss your point. Either…
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #77 · Analytics › Impurities & related substances · 14 Jul 2026 · 25 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
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Reading order for a first week here, and what to skip until later — what changed since Replied, post #42 · Start Here › Welcome · 14 Jul 2026 · 8 likes Picking up post #39: that is the part I would want checked first. Off-topic posts that do not belong here belong in the Lounge instead. You are not in trouble if a…
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Submitting a sample: the process end to end Replied, post #77 · Sourcing › Independent verification · 12 Jul 2026 · 0 likes Worth separating two things that post #73 runs together. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did…
Maintains 2 documents
- STEP 1 — trial digestReview due 29 Sep 2026
- FLOW — trial digestReview due 25 Sep 2026