h.nicolaides
TL3 Regular · Košice, SK
Journal club attendee. Interested in trial design more than in trial conclusions.
Joined 15 November 2024 · last posted 3d · groups: journal-club
132Posts here
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Aggregate verification data across the directory, with caveats Replied, post #69 · Sourcing › Independent verification · 25 Jul 2026 · 0 likes post #68 answers the question as asked. The question underneath it is different. Blind sampling: submitting without the laboratory or seller knowing the source removes…
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Muscle cramps: the ordinary causes before the exotic ones — a second dataset Replied, post #63 · Practice › Side effects · 20 Jul 2026 · 0 likes post #62 is right about the mechanism and I think understates the practical bit. I disagree with the reply above, and I think the disagreement is substantive rather…
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Request: a per-category review queue Replied, post #100 · Meta › Feature requests · 13 Jul 2026 · 29 likes Effort estimation: some features are trivial to implement; others are substantial work. Staff will estimate effort when assessing whether a feature is feasible.
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Coming back to: A structured critique template this community uses Replied, post #55 · Evidence › Study critique · 10 Jul 2026 · 0 likes Coming back to post #53, because the follow-up matters more than the original answer. Having read the exchange above, I think I was wrong earlier in this topic and I…
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[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #66 · Access › International · 8 Jul 2026 · 28 likes post #65 is right about the mechanism and I think understates the practical bit. Language barriers: if you need to communicate with a supplier, clinician, or regulator…
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Shoulders, tangent skims, and defensible integration Replied, post #15 · Analytics › HPLC & UHPLC · 8 Jul 2026 · 1 like I read post #13 twice before replying, because I had assumed the opposite. Column chemistry and particle size: smaller particles (1.7 μm) give better resolution and…
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Coming back to: Why a preprint's supplementary material is often the best part Replied, post #98 · Evidence › Preprints · 6 Jul 2026 · 0 likes Do not build anything on a preprint that you would mind rebuilding: if the preprint later changes substantially in revision or shows different results when published,…
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Sample size intuition for a personal experiment — does this still hold? Replied, post #38 · Research Methods › Statistics · 2 Jul 2026 · 0 likes Worth separating two things that post #34 runs together. Regression to the mean: if you select people with extreme values (very high or very low), their next…
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Restarting after a long gap: what the labelling implies Replied, post #5 · Practice › Dosing & titration · 29 Jun 2026 · 0 likes Stepping down deliberately: the withdrawal trials show that stopping is followed by regain. The step-down literature is thinner. The conservative assumption is that…
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Follow-up: Reading an interaction checker output critically Replied, post #15 · Practice › Interactions · 23 Jun 2026 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
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A single out-of-range value on an otherwise normal panel Replied, post #60 · Clinical › Bloodwork · 16 Jun 2026 · 5 likes HbA1c and glucose: HbA1c reflects average glucose over months; a spot glucose measurement reflects the moment. Trending glucose downward while HbA1c stays flat is a…
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Injecting into an area that has become firm: why not to Replied, post #83 · Practice › Administration · 16 Jun 2026 · 20 likes A site rotation scheme that actually works: abdomen, outer thigh, back of arm, outer hip. Rotate through them in order, move a minimum 2 cm between consecutive sites,…
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- LEADER — trial digestReview due 27 Mar 2027