Topic summary

Conditions that change the calculus rather than forbidding it

Safety › Contraindications disordered eating pregnancy & planning pancreatitis delayed gastric emptying

This is a generated summary. It shows the 5 most-liked posts from a topic of 33, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

r.laurentTL2 Moderator26 Mar 2026 · edited#5

b.fonseca, post #3: Disordered eating history: appetite suppression can trigger relapse in people with history of anorexia, bulimia, or other eating disorders. This is a relative contraindication requiring specialist input. Go to post

On the opening post — agreed on the reasoning, with one qualification.

Concurrent insulin or sulfonylureas: not an absolute contraindication but requires dose adjustment and close monitoring for hypoglycemia. The combination is used with caution, not avoided.

26 likes in reply to #3 4mo

taper_shiftTL3Regular16 Apr 2026#9

Severe hepatic impairment: less is known than for kidney disease. Extreme caution or contraindication depending on the specific degree of impairment.

19 likes 3mo

p.iyer_pharmdTL3Pharmacist26 Apr 2026#11

aliquot_line, post #1: Conditions that change the calculus rather than forbidding it Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published trials in this class mostly enrolled a fairly specific group, and the questions here frequently come from people well outside… Go to post

Diabetic retinopathy complications: a signal for this was noted in SUSTAIN 6. Current evidence is mixed. The risk is not zero and some caution is appropriate in people with baseline retinopathy.

22 likes in reply to #1 3mo

j.dahlbergTL2 Moderator5 Jun 2026#20

a.asante, post #2: Severe renal impairment (eGFR Go to post

Medullary thyroid carcinoma (personal or family history) or multiple endocrine neoplasia type 2: absolute contraindication. The rodent preclinical signal is real enough to exclude this population.

23 likes in reply to #2 2mo

t.kulkarniTL3Regular14 Jun 2026#22

g.oyelaran, post #21: Gastroparesis or severe delayed gastric emptying: these compounds slow gastric emptying. Pre-existing severe gastroparesis can be worsened. That is a relative contraindication depending on baseline severity. Go to post

Concurrent insulin or sulfonylureas: not an absolute contraindication but requires dose adjustment and close monitoring for hypoglycemia. The combination is used with caution, not avoided.

25 likes in reply to #21 1mo

Read the full topic (33 posts)

This topic was referenced in

Absolute versus relative contraindicationsSafety › Contraindications · 8 replies
Revisiting: Absolute versus relative contraindicationsSafety › Contraindications · 85 replies

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