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Access · Pricing · continued

Cost per milligram, computed honestly across formats — the long version posts 91–120

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

AL
a.lindholmTL2 Moderator7 May 2025#91
a.kowalski, post #9: International pricing: the same compound costs very different amounts in different countries because healthcare systems and regulatory frameworks differ. Generally, US prices are higher than other developed nations. Go to post

Price variation between pharmacies: identical prescriptions can cost different amounts at different pharmacies because pharmacies negotiate individually with insurers and manufacturers.

5 likes in reply to #9 15mo
BD
b.demirTL2 Moderator8 May 2025#92

International pricing: the same compound costs very different amounts in different countries because healthcare systems and regulatory frameworks differ. Generally, US prices are higher than other developed nations.

13 likes 15mo
SB
s.bruunTL2 Moderator8 May 2025#93

This follows post #90 rather than contradicting it.

For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.

0 likes 15mo
BO
b.oseiTL2 Moderator9 May 2025#94

Biosimilars and future generics: as patents expire, biosimilar and generic versions might become available and prices might fall. That has already happened for some proteins; incretin agonist pricing might follow.

0 likes 15mo
HA
h.amankwahTL2 Moderator10 May 2025#95
s.bruun, post #93: This follows post #90 rather than contradicting it. For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use. Go to post

Insurance tier placement: a compound might be covered but on a higher tier (higher copay). Moving to a lower tier usually requires prior authorization or documented failure of cheaper alternatives.

8 likes in reply to #93 15mo
B
BGiordanoTL2Member11 May 2025#96

Cost per milligram is the only comparison that survives format differences, but even then it needs care. A pen and a vial are not the same product and cannot be compared on price per milligram alone because dead volume, wastage, and number of doses actually obtainable differ.

19 likes 15mo
BV
b.vestergaardTL2 Moderator12 May 2025#97

Picking up post #94: that is the part I would want checked first.

Subscription services and subscriptions: some online clinics bundle compounds into subscription models with different pricing. Understanding the terms before committing matters.

0 likes 15mo
CD
c.delgadoTL2 Moderator13 May 2025#98

Coming back to post #96, because the follow-up matters more than the original answer.

Compute cost per delivered dose at your dose if you want a number you can act on. That requires knowing your dose, vial volume, and whether you are using a vial or a pen.

2 likes 15mo
HB
h.bhattacharyaTL2 Moderator13 May 2025#99

post #98 is right about the mechanism and I think understates the practical bit.

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

13 likes 14mo
CI
c.inglethorpeTL3Regular14 May 2025 · edited#100
OTeixeira, post #52: Subscription services and subscriptions: some online clinics bundle compounds into subscription models with different pricing. Understanding the terms before committing matters. Go to post

Worth separating two things that post #96 runs together.

List prices versus negotiated prices: the price a pharmaceutical company publishes and the price an insurance company or pharmacy actually pays differ substantially. List price is not what anyone pays.

26 likes in reply to #52 14mo
RE
r.erdoganTL2 Moderator15 May 2025#101

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

2 likes 14mo
DB
dr_bhattacharyaTL3Physician16 May 2025#102

Subscription services and subscriptions: some online clinics bundle compounds into subscription models with different pricing. Understanding the terms before committing matters.

9 likes 14mo
TD
t.duarteTL2 Moderator17 May 2025#103

Picking up post #100: that is the part I would want checked first.

Insurance tier placement: a compound might be covered but on a higher tier (higher copay). Moving to a lower tier usually requires prior authorization or documented failure of cheaper alternatives.

21 likes 14mo
EF
e.ferreiraTL3Regular18 May 2025 · edited#104
r.erdogan, post #101: I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient. Go to post

Cost per milligram is the only comparison that survives format differences, but even then it needs care. A pen and a vial are not the same product and cannot be compared on price per milligram alone because dead volume, wastage, and number of doses actually obtainable differ.

0 likes in reply to #101 14mo
EV
e.vargaTL2 Moderator18 May 2025#105

Compute cost per delivered dose at your dose if you want a number you can act on. That requires knowing your dose, vial volume, and whether you are using a vial or a pen.

5 likes 14mo
RA
r.aldana_pharmdTL4Pharmacist19 May 2025#106

List prices versus negotiated prices: the price a pharmaceutical company publishes and the price an insurance company or pharmacy actually pays differ substantially. List price is not what anyone pays.

14 likes 14mo
SO
s.okaforTL2 Moderator20 May 2025#107
g.ibarra, post #69: Worth separating two things that post #65 runs together. List prices versus negotiated prices: the price a pharmaceutical company publishes and the price an insurance company or pharmacy actually pays differ substantially. List price is not what anyone pays. Go to post

This follows post #104 rather than contradicting it.

Pharmacy acquisition cost: a pharmacy pays less than the patient pays, even at insurance rates. That margin is where the pharmacy's costs and profit live.

29 likes in reply to #69 14mo
LG
lc_gradientTL3Analytical chemist21 May 2025#108
b.osei, post #94: Biosimilars and future generics: as patents expire, biosimilar and generic versions might become available and prices might fall. That has already happened for some proteins; incretin agonist pricing might follow. Go to post

I read post #106 twice before replying, because I had assumed the opposite.

Discount programmes and coupons: manufacturers often offer coupons that reduce out-of-pocket costs if insurance is not covering or is covering at a high copay. These have eligibility restrictions but can save money.

0 likes in reply to #94 14mo
AN
a.nwosuTL2 Moderator22 May 2025#109
s.okafor, post #107: This follows post #104 rather than contradicting it. Pharmacy acquisition cost: a pharmacy pays less than the patient pays, even at insurance rates. That margin is where the pharmacy's costs and profit live. Go to post

post #108 answers the question as asked. The question underneath it is different.

Price variation between pharmacies: identical prescriptions can cost different amounts at different pharmacies because pharmacies negotiate individually with insurers and manufacturers.

0 likes in reply to #107 14mo
AB
a.batistaTL2 Moderator22 May 2025#110

On post #106 — agreed on the reasoning, with one qualification.

International pricing: the same compound costs very different amounts in different countries because healthcare systems and regulatory frameworks differ. Generally, US prices are higher than other developed nations.

3 likes 14mo
AC
a.cabreraTL2 Moderator23 May 2025#111

I read post #109 twice before replying, because I had assumed the opposite.

Biosimilars and future generics: as patents expire, biosimilar and generic versions might become available and prices might fall. That has already happened for some proteins; incretin agonist pricing might follow.

0 likes 14mo
CD
c.draganovTL1Member24 May 2025 · edited#112
b.osei, post #94: Biosimilars and future generics: as patents expire, biosimilar and generic versions might become available and prices might fall. That has already happened for some proteins; incretin agonist pricing might follow. Go to post

I disagree with the reply above, and I think the disagreement is substantive rather than terminological.

The distinction being drawn does not survive when you look at the published data for this specific question. I would be glad to be shown wrong on this, because the version I am arguing against is more convenient.

0 likes in reply to #94 14mo
VK
v.kjaerTL2 Moderator25 May 2025#113

International pricing: the same compound costs very different amounts in different countries because healthcare systems and regulatory frameworks differ. Generally, US prices are higher than other developed nations.

20 likes 14mo
DB
d.bramleyTL3Regular26 May 2025#114

Price variation between pharmacies: identical prescriptions can cost different amounts at different pharmacies because pharmacies negotiate individually with insurers and manufacturers.

8 likes 14mo
VB
v.bruunTL2 Moderator26 May 2025#115

List prices versus negotiated prices: the price a pharmaceutical company publishes and the price an insurance company or pharmacy actually pays differ substantially. List price is not what anyone pays.

2 likes 14mo
NT
nl_translatorTL2Translator · NL27 May 2025#116
a.batista, post #110: On post #106 — agreed on the reasoning, with one qualification. International pricing: the same compound costs very different amounts in different countries because healthcare systems and regulatory frameworks differ. Generally, US prices are higher than other developed nations. Go to post

Compute cost per delivered dose at your dose if you want a number you can act on. That requires knowing your dose, vial volume, and whether you are using a vial or a pen.

0 likes in reply to #110 14mo
BD
b.dumitruTL2 Moderator28 May 2025#117
a.vukovic, post #73: post #72 is right about the mechanism and I think understates the practical bit. Price variation between pharmacies: identical prescriptions can cost different amounts at different pharmacies because pharmacies negotiate individually with insurers and manufacturers. Go to post

Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own records is not any individual result; it is that they are dated and consecutive.

27 likes in reply to #73 14mo
EN
electrolyte_notesTL2Regular29 May 2025#118

post #117 answers the question as asked. The question underneath it is different.

Insurance tier placement: a compound might be covered but on a higher tier (higher copay). Moving to a lower tier usually requires prior authorization or documented failure of cheaper alternatives.

13 likes 14mo
YI
y.ibarraTL2 Moderator30 May 2025 · edited#119
dr_bhattacharya, post #102: Subscription services and subscriptions: some online clinics bundle compounds into subscription models with different pricing. Understanding the terms before committing matters. Go to post

I read post #117 twice before replying, because I had assumed the opposite.

Biosimilars and future generics: as patents expire, biosimilar and generic versions might become available and prices might fall. That has already happened for some proteins; incretin agonist pricing might follow.

0 likes in reply to #102 14mo
DM
d.moreauTL2Regular30 May 2025#120

This follows post #117 rather than contradicting it.

Subscription services and subscriptions: some online clinics bundle compounds into subscription models with different pricing. Understanding the terms before committing matters.

21 likes 14mo