BGiordano
TL2 Member · Salzburg, AT
Here for the documentation. Occasionally files a wiki request when a page has drifted out of date.
Joined 24 September 2024 · last posted 2d
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PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one Replied, post #28 · Compounds › Oral incretins · 26 Jul 2026 · 2 likes post #27 is right about the mechanism and I think understates the practical bit. Oral bioavailability is variable between people. Some people absorb well; others absorb…
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Common supplements people ask about, assessed one at a time Replied, post #94 · Practice › Interactions · 25 Jul 2026 · 24 likes Worth separating two things that post #90 runs together. Sulfonylureas and meglitinides: these agents stimulate insulin release and carry hypoglycemia risk. Combining…
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Reading order for a first week here, and what to skip until later — what changed since Replied, post #68 · Start Here › Welcome · 21 Jul 2026 · 32 likes Your introduction is well framed. You have given enough context that people can actually answer. That is rarer than it sounds and it matters more than it sounds.
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #95 · Evidence › Journal club · 21 Jul 2026 · 0 likes On post #91 — agreed on the reasoning, with one qualification. Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what…
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Mass error in ppm: the arithmetic and the caveat — a second dataset Replied, post #22 · Analytics › Mass spectrometry · 19 Jul 2026 · 0 likes Worth separating two things that post #18 runs together. What mass accuracy establishes: the measured mass is consistent with a specific composition. What it does not…
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Second pass at: Sleep apnoea improving and the equipment implications Replied, post #83 · Wellbeing › Sleep · 12 Jul 2026 · 1 like post #82 is right about the mechanism and I think understates the practical bit. Apnoea monitoring: if you have diagnosed or suspected sleep apnoea, periodic monitoring…
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Primary endpoint hierarchies and why order matters — one year on Replied, post #39 · Evidence › Trials · 8 Jul 2026 · 0 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
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[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Replied, post #19 · Analytics › HPLC & UHPLC · 7 Jul 2026 · 0 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #32 · Practice › Dosing & titration · 2 Jul 2026 · 6 likes post #31 is right about the mechanism and I think understates the practical bit. How the published trials escalated: they used specific step sizes and intervals. The…
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Why we ask for units every single time, with three examples of what goes wrong Replied, post #87 · Start Here › How to Ask · 1 Jul 2026 · 24 likes Picking up post #84: that is the part I would want checked first. Disagreement-style questions: "I read this and it contradicts what I heard here, which is right?" is…
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Molecular mass of semaglutide and why the figure differs between sources Replied, post #89 · Compounds › Semaglutide · 29 Jun 2026 · 10 likes Gastric emptying delay is the mechanism behind most of the gastrointestinal side effects. Slowing the stomach empties it feeds less food into the intestines at a time,…
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Athletes in weight-category sports: a different risk calculus Replied, post #5 · Clinical › Special populations · 27 Jun 2026 · 1 like Adolescents: a distinct evidence base exists. The compounds are not approved for routine adolescent obesity but are being studied. Adolescent physiology and psychology…