Safety · Contraindications · continued

Follow-up: Conditions that change the calculus rather than forbidding it posts 31–35

Safety › Contraindications pancreatitis disordered eating thyroid C-cell question pregnancy & planning

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

n.ibarraTL225 Jul 2024#31

Collapsed as off-topic by two members at trust level 3 or above

Diabetic retinopathy complications: a signal for this was noted in SUSTAIN 6. Current evidence is mixed. The risk is not zero and some caution is appropriate in people with baseline retinopathy.

system_suitabilityTL3Analytical chemist25 Jul 2024#32

post #31 answers the question as asked. The question underneath it is different.

Gastroparesis or severe delayed gastric emptying: these compounds slow gastric emptying. Pre-existing severe gastroparesis can be worsened. That is a relative contraindication depending on baseline severity.

28 likes 2y

s.balogunTL2 Moderator26 Jul 2024#33

system_suitability, post #32: post #31 answers the question as asked. The question underneath it is different. Gastroparesis or severe delayed gastric emptying: these compounds slow gastric emptying. Pre-existing severe gastroparesis can be worsened. That is a relative contraindication depending on baseline severity. Go to post

Coming back to post #31, because the follow-up matters more than the original answer.

Concurrent insulin or sulfonylureas: not an absolute contraindication but requires dose adjustment and close monitoring for hypoglycemia. The combination is used with caution, not avoided.

9 likes in reply to #32 2y

k.otieno_statsTL3Statistician26 Jul 2024#34

Allergy to the specific compound: true allergy is rare but possible. Any prior allergic reaction to the same compound or to structurally similar peptides warrants caution.

2 likes 2y

r.vukovicTL2 Moderator26 Jul 2024 · edited#35

Worth separating two things that post #31 runs together.

Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing.

The correction was fair and I had been repeating something I had not checked carefully enough.

0 likes 2y

Suggested topics

Topic	Participants	Replies	Views	Activity
Severe gastroparesis and why this class is a poor fit Safety › Contraindications pancreatitis pregnancy & planning delayed gastric emptying Solved On the subject in the title: Severe gastroparesis and why this class is a poor fit Working notes rather than a conclusion. Asking about a population rather than about a person. The published trials in this…		3	62k	13mo
Revisiting: Absolute versus relative contraindications Safety › Contraindications disordered eating delayed gastric emptying thyroid C-cell question pancreatitis Revisiting: Absolute versus relative contraindications — setting out what I have, and where I think it stops being reliable. Asking about a population rather than about a person. The published trials in this…	+80	85	7.4k	3mo
Pregnancy as an absolute contraindication — the long version Safety › Contraindications disordered eating pregnancy & planning delayed gastric emptying Under review On the subject in the title: Pregnancy as an absolute contraindication — the long version Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the…		2	5.3k	14mo
Personal or family history of medullary thyroid carcinoma — what changed since Safety › Contraindications pancreatitis thyroid C-cell question delayed gastric emptying Posting this under the heading it deserves: Personal or family history of medullary thyroid carcinoma — what changed since Everything below is what sits behind that. Asking about a population rather than…	+91	96	1.3k	25d
Pancreatitis history and the risk calculus Safety › Contraindications delayed gastric emptying thyroid C-cell question pancreatitis pregnancy & planning Solved Posting this under the heading it deserves: Pancreatitis history and the risk calculus Everything below is what sits behind that. Asking about a population rather than about a person. The published trials in…	+28	32	52k	17h

Related topics — sharing the tags pancreatitis, disordered eating, thyroid C-cell question

Topic	Participants	Replies	Views	Activity
Documenting an adverse event properly — the long version Safety › Adverse events delayed gastric emptying pancreatitis hypoglycaemia gallbladder Posting this under the heading it deserves: Documenting an adverse event properly — the long version Everything below is what sits behind that. General question, not a request for advice about my own care — I…	+1	5	4.8k	14mo
Hepatic impairment and the absence of data — a second dataset Clinical › Special populations adolescents disordered eating pregnancy & planning older adults Pinned On the subject in the title: Hepatic impairment and the absence of data — a second dataset Working notes rather than a conclusion. Asking about a population rather than about a person. The published trials in…		2	4.3k	4mo
Older adults, sarcopenia risk, and the trade-off nobody quantifies — does this still hold? Clinical › Special populations disordered eating chronic kidney disease pregnancy & planning Solved Asking directly, because I could not find a straight answer: Older adults, sarcopenia risk, and the trade-off nobody quantifies — does this still hold? General question, not a request for advice about my own…		2	22k	11mo
Persistent vomiting and the threshold for seeking help — one year on Safety › Adverse events hypoglycaemia vomiting gallbladder delayed gastric emptying Persistent vomiting and the threshold for seeking help — one year on Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice about my own…	+39	43	596	19mo
Mood changes: monitoring, and when to involve a professional Wellbeing › Mental health mood beginner friendly disordered eating Mood changes: monitoring, and when to involve a professional — setting out what I have, and where I think it stops being reliable. General question, not a request for advice about my own care — I know the…		2	362	13mo