Topic summary

History of disordered eating and why it changes the conversation

Clinical › Special populations older adults chronic kidney disease adolescents bariatric surgery history disordered eating Closed

This is a generated summary. It shows the 5 most-liked posts from a topic of 25, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

b.aaltoTL2 Moderator26 Jul 2025#6

Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the kind that comes from remembering a figure instead of looking it up.

29 likes 12mo

y.asanteTL2 Moderator18 Aug 2025#9

dr_okonkwo, post #2: the opening post answers the question as asked. The question underneath it is different. Medullary thyroid carcinoma history: an absolute contraindication because of the preclinical findings in rodent toxicology. The history (personal or family, especially multiple endocrine neoplasia type 2) is an important screening question. Go to post

Hypoglycemia risk: in people already on insulin or sulfonylureas, adding a GLP-1 agonist requires insulin dose reduction and close monitoring for hypoglycemia. This is manageable with attention.

23 likes in reply to #2 11mo

s.okonkwoTL2 Moderator23 Sep 2025#14

journalclub_wren, post #10: Disordered eating history: a history of anorexia nervosa, bulimia, or other eating disorders changes the risk-benefit calculation because appetite suppression might trigger relapse. This population requires specialist input. Go to post

Hypoglycemia risk: in people already on insulin or sulfonylureas, adding a GLP-1 agonist requires insulin dose reduction and close monitoring for hypoglycemia. This is manageable with attention.

23 likes in reply to #10 10mo

t.batistaTL2 Moderator19 Oct 2025#18

bench_peak, post #11: post #10 is right about the mechanism and I think understates the practical bit. Gastroparesis: pre-existing severe delayed gastric emptying can worsen with compounds that slow it further. Discussion with a clinician is prudent if this history exists. Go to post

Older adults: sarcopenia risk is higher, polypharmacy is common, and the clinical trials did not enroll many people over 75. Extrapolating to very old people is extrapolating beyond the data.

31 likes in reply to #11 9mo

OTeixeiraTL3Regular13 Nov 2025#22

Renal impairment: the compounds are cleared renally to some degree. Dose adjustments might be needed in severe renal impairment. Consulting with a clinician familiar with renal dosing is prudent.

31 likes 8mo

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This topic was referenced in

Pregnancy and pregnancy planning: contraindication and washoutClinical › Special populations · 122 replies

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