This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.
Coming back to post #29, because the follow-up matters more than the original answer.
Antioxidants: compounds that prevent oxidation (which damages peptides) are sometimes included. Methionine oxidation is a common degradation pathway and antioxidants help prevent it.
Picking up post #29: that is the part I would want checked first.
Amino acid residues and formulation: the specific sequence and composition of a peptide affects what formulation conditions it tolerates. Sequences high in methionine need more antioxidant protection. Sequences prone to aggregation need different pH or additive protection.
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Follow-up: Lyophilisation and why the cake looks the way it does
Lyophilisation and why the cake looks the way it does Writing it up because I had to work it out twice and would rather nobody else did. I would like to understand what this number means before I repeat it…
|
+10 | 14 | 11k | 3mo |
|
Second pass at: Isotonicity and what happens when you get it wrong
Second pass at: Isotonicity and what happens when you get it wrong — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it checked.…
|
+1 | 5 | 2.6k | 11mo |
|
Excipient function in a licensed injectable — the long version
Posting this under the heading it deserves: Excipient function in a licensed injectable — the long version Everything below is what sits behind that. Working through the identity arithmetic and I would like…
|
2 | 100 | 15mo | |
|
Coming back to: Solubility limits and what a cloudy solution is telling you
On the subject in the title: Solubility limits and what a cloudy solution is telling you Working notes rather than a conclusion. A documentation question rather than an analytical one. I have a certificate in…
|
+38 | 43 | 29k | 13h |
|
Coming back to: Adsorption to container surfaces and to plastics
Adsorption to container surfaces and to plastics — setting out what I have, and where I think it stops being reliable. Posting the method first, because I know what the first three replies will otherwise be.…
|
2 | 459 | 17mo |
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Residual solvents and scavengers: what is looked for
On the subject in the title: Residual solvents and scavengers: what is looked for Working notes rather than a conclusion. Posting the method first, because I know what the first three replies will otherwise…
|
+19 | 23 | 39k | 14mo |
|
Freeze-thaw and why one cycle is not the same as five
On the subject in the title: Freeze-thaw and why one cycle is not the same as five Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am asking rather…
|
+21 | 25 | 41k | 8mo |
|
Impurity thresholds: where the common numbers come from — what changed since
Posting this under the heading it deserves: Impurity thresholds: where the common numbers come from — what changed since Everything below is what sits behind that. A documentation question rather than an…
|
2 | 61k | 3mo | |
|
About the Cold chain category
Domestic refrigeration, travel, temperature logging, and assessing an excursion after the fact. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…
|
4 | 2k | 17mo | |
|
Isotope patterns and why the monoisotopic peak is not the tallest
Isotope patterns and why the monoisotopic peak is not the tallest — setting out what I have, and where I think it stops being reliable. Working through the identity arithmetic and I would like it checked.…
|
+12 | 16 | 7.5k | 17mo |