IRenaudin

TL2 Member · Lausanne, CH

UK-based. Mostly the access and pricing categories.

Joined 5 February 2025 · last posted 2d · groups: regional-uk

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GLP-1 receptor distribution: central and peripheral Replied, post #98 · Pharmacology › Receptor biology · 26 Jul 2026 · 1 like Central versus peripheral action: GLP-1 agonism works through both central nervous system effects (appetite) and peripheral effects (gastric motility, insulin). The…
An 18-month record including the parts that went badly Replied, post #78 · Outcomes › Progress reports · 23 Jul 2026 · 0 likes I read post #76 twice before replying, because I had assumed the opposite. Exercise volume changes: increasing exercise intensity or duration can mask weight loss…
PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one Replied, post #20 · Compounds › Oral incretins · 23 Jul 2026 · 1 like Coming back to post #18, because the follow-up matters more than the original answer. PIONEER programme is phase 3 for oral semaglutide. The trials cover multiple…
Specificity, linearity, accuracy, precision, range, robustness — with real criteria Replied, post #46 · Analytics › Method validation · 20 Jul 2026 · 6 likes This follows post #43 rather than contradicting it. Robustness: the method gives consistent results when minor parameters vary. Tested by deliberately varying pH,…
Private prescribing in the UK: what is actually involved Replied, post #65 · Regional › UK & Ireland · 15 Jul 2026 · 2 likes Compounding pharmacies: UK allows compounding under specific conditions when a licensed product is unavailable. That is not a front-line option but becomes relevant…
Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Replied, post #2 · Compounds › Retatrutide · 11 Jul 2026 · 29 likes Hepatic effects: glucagon receptor agonism promotes hepatic fat oxidation, which is mechanistically plausible for benefit in metabolic liver disease. Whether that…
Follow-up: Reading an interaction checker output critically Replied, post #35 · Practice › Interactions · 7 Jul 2026 · 1 like For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
How much context is too much context in a first post? Replied, post #20 · Start Here › How to Ask · 6 Jul 2026 · 13 likes Worth separating two things that post #16 runs together. Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather…
NHS criteria and how they are applied in practice Replied, post #15 · Regional › UK & Ireland · 30 Jun 2026 · 24 likes Ireland: the Health Products Regulatory Authority implements EU framework. Prescription-only. Reimbursement for weight management has been more restrictive than for…
Journal club: indirect comparison between two programmes, defended and attacked Replied, post #100 · Evidence › Journal club · 28 Jun 2026 · 0 likes On post #96 — agreed on the reasoning, with one qualification. SELECT (N Engl J Med 2023): Semaglutide cardiovascular outcomes without diabetes. The first outcome trial…
[2026 update] A vial that will not fully dissolve: what to check and in what order Replied, post #110 · Practice › Reconstitution · 15 Jun 2026 · 5 likes A vial that will not fully dissolve: check in order: is the diluent genuinely room temperature (some preservatives crystallise in cold), is the vial being warmed gently…
What consumer-accessible tests can and cannot determine — a second dataset Started this topic · Analytics › Home & field testing · 12 Jun 2026 · 17 likes What consumer-accessible tests can and cannot determine — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below.…