Nardone
TL2 Member · Dijon, FR
Practical questions, practical answers. Not interested in speculation without a source.
Joined 10 December 2024 · last posted 8d
85Posts here
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Second pass at: When your prescriber and the evidence disagree Replied, post #53 · Clinical › Prescriber conversations · 20 Jul 2026 · 30 likes post #52 answers the question as asked. The question underneath it is different. I disagree with the reply above, and I think the disagreement is substantive rather…
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An 18-month record including the parts that went badly Replied, post #74 · Outcomes › Progress reports · 19 Jul 2026 · 0 likes Measurement noise: day-to-day body mass varies by more than a kilogram on hydration, glycogen, and gut contents alone. A weekly reading is a single noisy sample of a…
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Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Replied, post #6 · Compounds › Retatrutide · 17 Jul 2026 · 21 likes post #5 answers the question as asked. The question underneath it is different. Triple agonism: is the effect additive, synergistic, or neither? A phase 2 comparison of…
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Washout with a one-week half-life: the arithmetic — does this still hold? Replied, post #41 · Research Methods › N-of-1 designs · 15 Jul 2026 · 0 likes post #40 is right about the mechanism and I think understates the practical bit. Stopping rules: decide in advance when you will stop measuring (after a defined…
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Specificity, linearity, accuracy, precision, range, robustness — with real criteria Replied, post #42 · Analytics › Method validation · 12 Jul 2026 · 10 likes For anyone arriving from a search: the marked solution above is the direct answer, and the replies underneath it add the caveats that make it safe to use.
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Private prescribing in the UK: what is actually involved Replied, post #61 · Regional › UK & Ireland · 10 Jul 2026 · 5 likes post #60 is right about the mechanism and I think understates the practical bit. Compounding pharmacies: UK allows compounding under specific conditions when a licensed…
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[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Replied, post #17 · Analytics › HPLC & UHPLC · 7 Jul 2026 · 0 likes Before anything else: what was the gradient, and at what wavelength? Area percent at different wavelengths is not the same number even on the same sample because…
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Designing a personal experiment that could change your mind — one year on Replied, post #71 · Research Methods › N-of-1 designs · 6 Jul 2026 · 1 like I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
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What a simple presence test is genuinely useful for Replied, post #2 · Analytics › Home & field testing · 5 Jul 2026 · 3 likes Sample handling matters: if a sample is contaminated or degraded before testing, the test gives you the result for the degraded sample, not for fresh material. That is…
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How much context is too much context in a first post? Replied, post #16 · Start Here › How to Ask · 5 Jul 2026 · 8 likes Chromatogram questions: describe the method first. Column type, gradient, wavelength, detection method. Everything else follows from method. A chromatogram without…
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Follow-up: Reading an interaction checker output critically Replied, post #31 · Practice › Interactions · 4 Jul 2026 · 0 likes Anticoagulants: no direct interaction with the compounds in this class. Weight loss and body composition changes might affect the clearance or effect of warfarin if you…
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Review: a draft on reconstitution arithmetic, with objections — one year on Replied, post #38 · Documentation › Doc review · 3 Jul 2026 · 0 likes Citation checking: if a maintained page cites a paper, the citation should match what the paper actually says. If you notice a mismatch, post it here.