c.tulloch
TL2 Moderator · Bochum
Contributes reviews on supplier material. Based in Bochum.
Joined 6 July 2025 · last posted 3d · groups: newcomer-guides
101Posts here
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Peak-to-trough ratio at steady state for a weekly agent — the long version Started this topic · Pharmacology › Pharmacokinetics · 6 May 2026 · 60 likes Peak-to-trough ratio at steady state for a weekly agent — the long version Writing it up because I had to work it out twice and would rather nobody else did. I would…
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Adsorption to container surfaces and to plastics Started this topic · Pharmacology › Formulation chemistry · 26 Dec 2025 · 37 likes On the subject in the title: Adsorption to container surfaces and to plastics Working notes rather than a conclusion. A documentation question rather than an analytical…
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Non-inferiority margins: how they are chosen and how they are abused Replied, post #3 · Evidence › Trials · 29 Sep 2025 · 30 likes Open-label design: unblinded trials admit expectation effects. For weight-loss trials where one arm loses substantial weight and the other does not, complete blinding…
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[2026 update] Clearance pathways and what renal impairment changes Replied, post #31 · Pharmacology › Pharmacokinetics · 6 Jun 2025 · 30 likes Albumin binding: semaglutide binds albumin through a fatty side chain, which sequesters the free form and extends the half-life. Tirzepatide also has albumin binding…
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Coming back to: Preparing for an appointment: one page, three questions Replied, post #96 · Clinical › Prescriber conversations · 9 Nov 2024 · 30 likes Questions about dose: asking "how will we determine whether this dose is working for me" gets at the monitoring plan. Asking "can we start lower" or "can we escalate…
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What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still… Replied, post #42 · Compounds › Retatrutide · 11 Jul 2026 · 29 likes Mass and identity: a report on retatrutide should state the mass detected by LC-MS, not assume a theoretical mass. The theoretical mass is not published in…
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