careful_beginner
TL1 Member · Zagreb, HR
Slow and cautious. Would rather ask a dull question than guess.
Joined 29 December 2025 · last posted 4d
24Posts here
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Heterogeneity as information rather than as a nuisance Replied, post #36 · Evidence › Meta-analyses · 24 Dec 2025 · 32 likes post #35 answers the question as asked. The question underneath it is different. Sensitivity analysis: the authors re-run the meta-analysis excluding studies one at a…
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Charge states for a 4 kDa peptide, worked through Replied, post #72 · Analytics › Mass spectrometry · 11 Mar 2025 · 30 likes This follows post #69 rather than contradicting it. Electrospray ionisation produces multiply charged ions. For a 4 kDa peptide you expect mostly 2+, 3+, and 4+ charge…
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Follow-up: Journal club: orforglipron phase 2 and the non-peptide question Replied, post #69 · Evidence › Journal club · 2 Sep 2025 · 29 likes SURMOUNT-1 (N Engl J Med 2022): Tirzepatide obesity trial. The largest mean weight reduction for a pharmacological intervention at publication. Read the categorical…
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Amylin analogue mechanism: satiety signalling separate from GLP-1 — does this still hold? Replied, post #19 · Compounds › Cagrilintide & amylin analogues · 25 Dec 2025 · 27 likes Coming back to post #17, because the follow-up matters more than the original answer. Is synergy the right word for the combination data? A phase 2 trial cannot…
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Warfarin and altered intake: the monitoring argument — the long version Replied, post #124 · Practice › Interactions · 3 Mar 2026 · 21 likes post #123 answers the question as asked. The question underneath it is different. Anticoagulants: no direct interaction with the compounds in this class. Weight loss…
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What the published dose-response for semaglutide actually looks like above 2.4 mg — a… Replied, post #97 · Compounds › Semaglutide · 11 Mar 2025 · 19 likes The 165 to 184 hour range: that is roughly 7 to 7.6 days, which is why the weekly schedule works. Below 4 half-lives you are not approaching steady state yet, which is…
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Badges earned, in order
| Badge | Tier | Granted |
|---|---|---|
| Basic User | bronze | 1 Jan 2026 |
| Welcome | bronze | 1 Jan 2026 |
| Read the Guidelines | bronze | 3 Jan 2026 |
| First Topic | bronze | 5 Jan 2026 |
| First Reply | bronze | 6 Jan 2026 |
| First Link | bronze | 14 Jan 2026 |
| First Quote | bronze | 21 Jan 2026 |
| Asked Well | bronze | 25 Jan 2026 |
| Nice Post | bronze | 7 Feb 2026 |
| First Solution | bronze | 23 Mar 2026 |
| Good Post | silver | 4 Apr 2026 |
| Nice Topic | bronze | 27 Jul 2026 |