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TL3 Regular · Leeuwarden, NL
Clinician. Posts general information only, and says so every time.
Joined 8 November 2024 · last posted 2h · groups: clinicians
143Posts here
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A widely repeated interaction claim that turns out to be unsupported — what changed since Replied, post #95 · Practice › Interactions · 28 Jul 2026 · 18 likes post #94 answers the question as asked. The question underneath it is different. I disagree with the reply above, and I think the disagreement is substantive rather…
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Follow-up: The most useful thing you learned here that was not the answer you came for Replied, post #34 · Lounge › Off topic · 26 Jul 2026 · 12 likes post #33 is right about the mechanism and I think understates the practical bit. I disagree with the reply above, and I think the disagreement is substantive rather…
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What is genuinely unknown about long-term amylin agonism Replied, post #89 · Compounds › Cagrilintide & amylin analogues · 26 Jul 2026 · 8 likes post #88 is right about the mechanism and I think understates the practical bit. I disagree with the reply above, and I think the disagreement is substantive rather…
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What is genuinely unknown about long-term amylin agonism Replied, post #56 · Compounds › Cagrilintide & amylin analogues · 19 Jul 2026 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
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Tirzepatide storage and stability: what is published versus what is assumed Replied, post #9 · Compounds › Tirzepatide · 12 Jul 2026 · 5 likes SURMOUNT-OSA is notable because it used an objective physiological endpoint, the apnoea-hypopnoea index, rather than a symptom scale. Two parallel trials, with and…
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A critique that turned out to be unfair, retracted by its author Replied, post #28 · Evidence › Study critique · 11 Jul 2026 · 2 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #54 · Practice › Dosing & titration · 11 Jul 2026 · 1 like I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
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Why we ask for units every single time, with three examples of what goes wrong Replied, post #112 · Start Here › How to Ask · 9 Jul 2026 · 16 likes Five questions in one post gets you one answer: the easiest one, usually not the one you needed most. Post them separately or pick the one that depends on the others…
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A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #116 · Practice › Reconstitution · 8 Jul 2026 · 1 like A 10 mg vial reconstituted three different ways: 1 mL diluent gives 10 mg/mL, 2 mL gives 5 mg/mL, 4 mL gives roughly 2.5 mg/mL. The arithmetic is the same; the…
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Tracking a shortage from primary sources rather than rumour Replied, post #76 · Access › Shortages · 29 Jun 2026 · 13 likes On post #72 — agreed on the reasoning, with one qualification. Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking…
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Journal club: what we got wrong in an earlier session Replied, post #28 · Evidence › Journal club · 25 Jun 2026 · 0 likes SURMOUNT-OSA (N Engl J Med 2024): Tirzepatide in obstructive sleep apnoea, using an objective physiological endpoint. Notable because soft endpoints are avoided. Two…
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NHS criteria and how they are applied in practice Replied, post #10 · Regional › UK & Ireland · 24 Jun 2026 · 13 likes Ireland: the Health Products Regulatory Authority implements EU framework. Prescription-only. Reimbursement for weight management has been more restrictive than for…