f.fonseca

TL2 Moderator · Trondheim

Contributes reviews on supplier material. Based in Trondheim.

Joined 1 October 2025 · last posted 5d

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Restarting after a long gap: what the labelling implies Replied, post #40 · Practice › Dosing & titration · 23 Jul 2026 · 21 likes Steady state means the plasma concentration is stable from dose to dose. That happens around 4 to 5 half-lives. Before that, the concentration is rising with each dose.…
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #111 · Evidence › Journal club · 16 Jul 2026 · 24 likes On post #107 — agreed on the reasoning, with one qualification. STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most…
Tracking intake honestly when appetite is absent Replied, post #85 · Nutrition & Training › Protein & intake · 4 Jul 2026 · 21 likes Picking up post #82: that is the part I would want checked first. Micronutrition alongside protein: eating protein foods that are also good sources of micronutrients…
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #73 · Evidence › Journal club · 1 Jul 2026 · 1 like Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the design answer that question? (3) Was the population sufficiently similar to your…
Coming back to: Where the four-week escalation interval comes from, and what it is not Replied, post #5 · marked as the solution · Practice › Dosing & titration · 29 Jun 2026 · 7 likes Titrating on tolerability rather than on the calendar: some people escalate when they tolerate a dose well, others escalate on the prescribed schedule regardless. The…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #95 · Practice › Reconstitution · 23 Jun 2026 · 7 likes Osmolarity and reconstitution: the osmolarity of the reconstituted solution affects comfort on injection. Isotonic solutions (close to blood osmolarity) are less…
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #91 · Evidence › Journal club · 14 Jun 2026 · 3 likes post #90 answers the question as asked. The question underneath it is different. Session format: read the paper before posting. The discussion is much better when…
Prescription requirements and telehealth models — a second dataset Replied, post #40 · Sourcing › Regulatory · 24 May 2026 · 6 likes Labelling and intended use: a compound sold as "research-use-only" does not change its pharmacology if ingested. It changes the legal status of the sale. The labelling…
How much fluid is actually needed, and how you would know Replied, post #11 · Nutrition & Training › Hydration & electrolytes · 22 May 2026 · 4 likes This follows post #8 rather than contradicting it. Sodium: losing weight involves losing some sodium. Electrolyte drinks or salty foods help maintain sodium balance.…
Revisiting: What pooling buys you and what it destroys Replied, post #28 · Evidence › Meta-analyses · 20 May 2026 · 0 likes I read post #26 twice before replying, because I had assumed the opposite. Pooled estimates and heterogeneity: when trials differ in population, duration, or…
Fasting versus non-fasting and which tests care Replied, post #26 · Clinical › Bloodwork · 10 May 2026 · 0 likes post #25 answers the question as asked. The question underneath it is different. Renal function markers: eGFR is estimated, not measured. It depends on creatinine, age,…
Type 2 diabetes and the largest part of the evidence base — does this still hold? Replied, post #8 · marked as the solution · Clinical › Comorbidities · 8 May 2026 · 8 likes PCOS and metabolic overlap: polycystic ovary syndrome has metabolic overlap with obesity and insulin resistance. Data on compounds in this class in PCOS specifically is…