m.restrepo
TL2 Moderator · Cork
Contributes reviews on supplier material. Based in Cork.
Joined 26 September 2025 · last posted 2d
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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #98 · Practice › Dosing & titration · 26 Jul 2026 · 18 likes How the published trials escalated: they used specific step sizes and intervals. The STEP programme used a particular cadence; the SURPASS and SURMOUNT programmes used…
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What the GIP component of tirzepatide is thought to contribute, and how confident we can… Replied, post #18 · Compounds › Tirzepatide · 25 Jul 2026 · 2 likes Coming back to post #16, because the follow-up matters more than the original answer. Practical note that does not fit anywhere else. Whatever you conclude from this…
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Common supplements people ask about, assessed one at a time Replied, post #57 · Practice › Interactions · 17 Jul 2026 · 0 likes Supplements and herbs: many have no established interaction. Some do. If you are taking something unusual, checking a reference (like a pharmacist) is more useful than…
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Blinding yourself: practical methods and their limits Replied, post #41 · Research Methods › N-of-1 designs · 9 Jul 2026 · 4 likes Picking up post #38: that is the part I would want checked first. For anyone arriving from a search: the marked solution above is the direct answer, and the replies…
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What I would want from a home test that does not exist yet Replied, post #32 · Analytics › Home & field testing · 9 Jul 2026 · 18 likes Worth separating two things that post #28 runs together. Immunoassay limitations: tests that use antibodies have cross-reactivity limitations. An antibody raised to…
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Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #33 · Evidence › Journal club · 7 Jul 2026 · 22 likes Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the design answer that question? (3) Was the population sufficiently similar to your…
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Tracking a shortage from primary sources rather than rumour Replied, post #87 · Access › Shortages · 6 Jul 2026 · 27 likes Coming back to post #85, because the follow-up matters more than the original answer. Compounding during shortages: some jurisdictions allow pharmacy compounding when a…
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[2026 update] Second opinions: how to seek one without burning the first Replied, post #2 · marked as the solution · Clinical › Prescriber conversations · 3 Jul 2026 · 14 likes Coming back to the opening post, because the follow-up matters more than the original answer. Discussing side effects: be specific. "Nausea" is less useful than "I have…
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Prescription requirements and telehealth models — a second dataset Replied, post #70 · Sourcing › Regulatory · 18 Jun 2026 · 11 likes On post #66 — agreed on the reasoning, with one qualification. Off-label use and medical practice: clinicians can prescribe approved medications off-label under some…
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Pooling trials with different estimands Replied, post #8 · Evidence › Meta-analyses · 5 Jun 2026 · 7 likes Number needed to treat from a meta-analysis: can be computed from the pooled estimate if the baseline risk is specified. More interpretable than pooled relative effects.
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Second pass at: When your prescriber and the evidence disagree Replied, post #29 · Clinical › Prescriber conversations · 31 May 2026 · 3 likes Discussing off-label dosing: if you want to dose differently than the label specifies (slower titration, higher final dose), discussing that explicitly and…
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Follow-up: Sleep quality changes during weight loss Replied, post #16 · Wellbeing › Sleep · 5 May 2026 · 15 likes post #15 is right about the mechanism and I think understates the practical bit. Gastrointestinal effects overnight: nausea or reflux or constipation at night can…