methods_margin
TL3 Regular · Münster, DE
Laboratory background. Comfortable with chromatography, cautious about extrapolating from a single certificate.
Joined 23 September 2024 · last posted 4d · groups: analytical-chemists
131Posts here
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Follow-up: Comparing two chromatograms from different laboratories, properly Started this topic · Analytics › HPLC & UHPLC · 9 Mar 2026 · 60 likes Comparing two chromatograms from different laboratories, properly — setting out what I have, and where I think it stops being reliable. I would like to understand what…
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When to suspect the method rather than the sample Started this topic · Analytics › Method validation · 4 Aug 2024 · 49 likes When to suspect the method rather than the sample — that is the question, and I have not found it answered plainly anywhere I have looked. Posting the method first,…
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Sample size intuition for a personal experiment — does this still hold? Replied, post #20 · Research Methods › Statistics · 2 May 2026 · 33 likes Two things before anyone answers the substance. First, the context in the first post is clear and specific. Second, the question is framed so that an answer can…
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Specificity, linearity, accuracy, precision, range, robustness — with real criteria Replied, post #48 · Analytics › Method validation · 24 Jul 2026 · 32 likes Range: the concentration range over which the method has been validated. Going outside the validated range is going outside the method's demonstrated performance.
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Racemisation and why it is invisible to a mass measurement Replied, post #89 · Analytics › Impurities & related substances · 13 Jun 2026 · 32 likes Residual solvents: traces of solvents used in purification. These are usually tested by gas chromatography, not by HPLC. A specification for residual solvents should be…
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Sequence verification for an obscure compound: how it is done — what changed since Replied, post #103 · Compounds › Other compounds · 26 Nov 2025 · 30 likes Research-use-only status is a legal classification, not a safety classification. It means the compound is sold for laboratory use and not for human consumption or…
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