n.nakamura
TL2 Moderator · Leuven
Contributes reviews on supplier material. Based in Leuven.
Joined 13 July 2025 · last posted 2d
91Posts here
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Peer-to-peer review: what actually happens on the call Started this topic · Access › Insurance & coverage · 26 Dec 2025 · 46 likes On the subject in the title: Peer-to-peer review: what actually happens on the call Working notes rather than a conclusion. Documenting an access outcome, dated,…
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Albumin binding and how it produces a long half-life Replied, post #37 · Pharmacology › Pharmacokinetics · 17 May 2025 · 33 likes Hepatic metabolism: the degree to which each compound is hepatically metabolised versus renally cleared is known but varies. Severe liver disease changes clearance.
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Racemisation and why it is invisible to a mass measurement Replied, post #49 · Analytics › Impurities & related substances · 11 Jun 2026 · 30 likes Residual solvents: traces of solvents used in purification. These are usually tested by gas chromatography, not by HPLC. A specification for residual solvents should be…
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Oral semaglutide bioavailability and its variability between people — a second dataset Replied, post #50 · Compounds › Oral incretins · 26 Dec 2024 · 29 likes Trial adherence in an oral trial with strict administration requirements is genuinely worse than trial-published data often suggests. That is why the exposure…
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What a stability-indicating method is and how you demonstrate one — one year on Replied, post #67 · Analytics › Method validation · 6 Nov 2024 · 29 likes Precision and repeatability: within-run and between-run variability of the method. Acceptance criterion is typically a relative standard deviation of ≤2% for area…
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HbA1c lag and what it can and cannot tell you at eight weeks — one year on Replied, post #6 · Clinical › Bloodwork · 26 May 2026 · 28 likes On post #2 — agreed on the reasoning, with one qualification. TSH and free hormones: TSH is a reasonable screening test but does not tell you about actual free hormone…
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