o.cousineau
TL3 Regular · Zlín, CZ
Long-standing member. Posts carefully and infrequently, mostly in the practice and analytics categories.
Joined 5 August 2024 · last posted 23h
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Journal club: what we got wrong in an earlier session Replied, post #126 · Evidence › Journal club · 27 Jul 2026 · 8 likes post #125 is right about the mechanism and I think understates the practical bit. Critical appraisal template: (1) What did the trial set out to estimate? (2) Could the…
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Second pass at: What a 2 ppm match establishes, and what it does not Replied, post #49 · Analytics › Mass spectrometry · 25 Jul 2026 · 12 likes On post #45 — agreed on the reasoning, with one qualification. Electrospray ionisation produces multiply charged ions. For a 4 kDa peptide you expect mostly 2+, 3+, and…
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Private prescribing in the UK: what is actually involved Replied, post #73 · Regional › UK & Ireland · 23 Jul 2026 · 26 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
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Micro-titration: a disputed topic, argued properly Replied, post #107 · Practice › Dosing & titration · 19 Jul 2026 · 0 likes Micro-titration: the concept of increments smaller than the labelled steps. It has no evidence base from trials but is described by some people. The downside is that…
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Muscle cramps: the ordinary causes before the exotic ones — a second dataset Replied, post #59 · Practice › Side effects · 18 Jul 2026 · 0 likes I read post #57 twice before replying, because I had assumed the opposite. Having read the exchange above, I think I was wrong earlier in this topic and I want to say…
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Tracking a shortage from primary sources rather than rumour Replied, post #106 · Access › Shortages · 16 Jul 2026 · 1 like Coming back to post #104, because the follow-up matters more than the original answer. Shortage predictions: regulators and suppliers issue shortage alerts before they…
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Revisiting: The best-written scientific paper you have read Replied, post #94 · Lounge › Off topic · 16 Jul 2026 · 0 likes Personal stories: if you want to talk about what led you to this compound, your journey, or how the change has affected your life, the Lounge is the place for that.
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Pooling trials with different estimands Replied, post #90 · Evidence › Meta-analyses · 12 Jul 2026 · 3 likes When a meta-analysis is unhelpful: if the included studies are heterogeneous in population, intervention, or outcome, pooling them produces a number that represents…
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Revisiting: The best-written scientific paper you have read Replied, post #83 · Lounge › Off topic · 10 Jul 2026 · 3 likes This follows post #80 rather than contradicting it. Humour: light, relevant humour is welcome. Cruel humour targeting individuals or groups is not.
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Osteoarthritis and mechanical versus metabolic improvement — one year on Replied, post #22 · Clinical › Comorbidities · 10 Jul 2026 · 0 likes Worth separating two things that post #18 runs together. Multiple comorbidities: a person with diabetes, kidney disease, and cardiovascular disease is outside the…
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Asking a follow-up: new topic or new reply? Replied, post #46 · Start Here › How to Ask · 10 Jul 2026 · 0 likes Asking a follow-up: new topic or reply in the old one? If the answer depends on the previous post, reply. If it is a question that makes sense without the previous…
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Programming during a large energy deficit Replied, post #35 · Nutrition & Training › Resistance training · 8 Jul 2026 · 30 likes post #34 answers the question as asked. The question underneath it is different. Cardio and resistance: the interaction between energy-intense cardiovascular training…