s.stavrianos
TL2 Member · Winnipeg, CA
Keeps a personal log and shares the numbers when they are relevant, with the measurement caveats attached.
Joined 21 March 2025 · last posted 2d
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Follow-up: The retatrutide phase 2 obesity paper, read closely Replied, post #24 · Compounds › Retatrutide · 26 Jul 2026 · 5 likes post #23 is right about the mechanism and I think understates the practical bit. I disagree with the reply above, and I think the disagreement is substantive rather…
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[2026 update] Documenting an adverse event properly Replied, post #21 · Safety › Adverse events · 25 Jul 2026 · 28 likes Practical note that does not fit anywhere else. Whatever you conclude from this topic, write down what you did and when. The single most useful thing in your own…
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CJC-1295 with and without DAC: what the modification does Replied, post #117 · Compounds › Secretagogues & GH axis · 20 Jul 2026 · 11 likes Why this subcategory is stricter about sourcing than most: the evidence base is weaker and that is precisely why documentation quality matters more. A supplier page…
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Forced degradation studies: designing one that is informative Replied, post #96 · Analytics › Method validation · 11 Jul 2026 · 0 likes Accuracy: the method measures what you intend to measure. For purity methods, this is tested by spike-and-recover experiments: add a known amount of impurity to a…
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Follow-up: Sleep quality changes during weight loss Replied, post #66 · Wellbeing › Sleep · 10 Jul 2026 · 0 likes Obstructive sleep apnoea: pre-existing OSA can worsen with weight before it improves (apnoea-hypopnoea index goes up as soft tissue inflames before weight is lost).…
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Revisiting: What pooling buys you and what it destroys Replied, post #75 · Evidence › Meta-analyses · 1 Jul 2026 · 24 likes Having read the exchange above, I think I was wrong earlier in this topic and I want to say so plainly rather than quietly editing. The correction was fair and I had…
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Personal or family history of medullary thyroid carcinoma — what changed since Replied, post #77 · Safety › Contraindications · 17 Jun 2026 · 0 likes I read post #75 twice before replying, because I had assumed the opposite. Medullary thyroid carcinoma (personal or family history) or multiple endocrine neoplasia type…
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Second pass at: Programming during a large energy deficit Replied, post #30 · Nutrition & Training › Resistance training · 16 Jun 2026 · 26 likes Intensity: using weights that allow 6 to 12 reps before fatigue is a reasonable range for preserving muscle. Heavier weights with lower reps can work but require more…
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Why this subcategory is stricter about sourcing than most Replied, post #42 · Compounds › Secretagogues & GH axis · 13 Jun 2026 · 2 likes Coming back to post #40, because the follow-up matters more than the original answer. What a well-designed human trial of a secretagogue would look like: randomised,…
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[2026 update] Interpreting a result that disagrees with the supplier's certificate Started this topic · Sourcing › Independent verification · 3 Jun 2026 · 38 likes On the subject in the title: Interpreting a result that disagrees with the supplier's certificate Working notes rather than a conclusion. Structured report rather than…
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GLP-1 receptor distribution: central and peripheral Replied, post #58 · Pharmacology › Receptor biology · 28 May 2026 · 0 likes Pharmacological class effects: all GLP-1 agonists slow gastric emptying and suppress appetite. Those are class effects, not unique to one compound. Effects that differ…
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Why the titration planner refuses to produce a schedule below a floor Replied, post #77 · Data & Tools › Calculators · 23 May 2026 · 3 likes Mass error checking: enter your observed mass and theoretical mass and check whether the difference in ppm is within reasonable bounds for your instrument. Useful…