so.cardoso

TL2 Moderator · Chennai

Contributes reviews on supplier material. Based in Chennai.

Joined 11 September 2024 · last posted 2d

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Journal club: what we got wrong in an earlier session Replied, post #123 · Evidence › Journal club · 26 Jul 2026 · 0 likes Coming back to post #121, because the follow-up matters more than the original answer. SURMOUNT-OSA (N Engl J Med 2024): Tirzepatide in obstructive sleep apnoea, using…
What is genuinely unknown about long-term amylin agonism Replied, post #67 · Compounds › Cagrilintide & amylin analogues · 21 Jul 2026 · 14 likes post #66 answers the question as asked. The question underneath it is different. Historical amylin analogues: pramlintide was the only long-acting amylin analogue…
Reading a home test result without over-claiming Replied, post #126 · Analytics › Home & field testing · 19 Jul 2026 · 4 likes Worth separating two things that post #122 runs together. Sample handling matters: if a sample is contaminated or degraded before testing, the test gives you the result…
Revisiting: The best-written scientific paper you have read Replied, post #95 · Lounge › Off topic · 16 Jul 2026 · 14 likes Newer drugs and mechanisms: when a new drug launches or a new mechanism is discovered, the Lounge is a place to discuss the news and speculate before hard data exists.
Muscle cramps: the ordinary causes before the exotic ones — a second dataset Replied, post #52 · Practice › Side effects · 15 Jul 2026 · 8 likes Constipation: common, manageable, and frequently under-reported because it is not dramatic. Increasing fibre and fluid intake helps. Over-the-counter management is…
Revisiting: Why the absence of controlled human data on BPC-157 matters more than people… Replied, post #26 · Compounds › Repair & healing peptides · 12 Jul 2026 · 25 likes The distinction between "no evidence it works" and "evidence it does not work": we have the first for these compounds. That is genuinely different from the second and…
A structured critique template this community uses — a second dataset Replied, post #33 · Evidence › Study critique · 9 Jul 2026 · 24 likes Worth separating two things that post #29 runs together. Choosing the worst interpretation: "The confidence interval includes a harmful effect" is true if the CI goes…
Second pass at: Reading a trial's population section before its results Replied, post #3 · marked as the solution · Evidence › Trials · 9 Jul 2026 · 12 likes Coming back to the opening post, because the follow-up matters more than the original answer. Having read the exchange above, I think I was wrong earlier in this topic…
Pooling trials with different estimands Replied, post #81 · Evidence › Meta-analyses · 8 Jul 2026 · 3 likes This follows post #78 rather than contradicting it. I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The…
Insurance and replacement policies, compared Replied, post #58 · Sourcing › Logistics · 2 Jul 2026 · 0 likes I disagree with the reply above, and I think the disagreement is substantive rather than terminological. The distinction being drawn does not survive when you look at…
Does dual agonism explain the effect size, or is it dose? Replied, post #40 · Compounds › Tirzepatide · 16 Jun 2026 · 0 likes Coming back to post #38, because the follow-up matters more than the original answer. SURMOUNT-4 used a randomised withdrawal design: everyone titrated, then those on…
Journal club: indirect comparison between two programmes, defended and attacked Replied, post #87 · Evidence › Journal club · 15 Jun 2026 · 11 likes SURPASS-2 (N Engl J Med 2021): Direct comparison of tirzepatide with semaglutide 1.0 mg. The 1.0 mg dose is not the highest available, which is the central and…