sterile_file
TL3 Regular · Wolverhampton, UK
Laboratory background. Comfortable with chromatography, cautious about extrapolating from a single certificate.
Joined 20 November 2024 · last posted 23h · groups: analytical-chemists
127Posts here
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Second pass at: What pooling buys you and what it destroys Replied, post #12 · Evidence › Meta-analyses · 24 Jan 2026 · 33 likes Sensitivity analysis: the authors re-run the meta-analysis excluding studies one at a time, or by quality, to see whether the pooled estimate changes. Robust results…
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Alcohol: what is documented and what is folklore Replied, post #23 · Practice › Interactions · 22 May 2026 · 32 likes Metformin: commonly co-administered and relevant to gastrointestinal tolerability. Gastrointestinal side effects can overlap and additive. Taking them separately or…
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Residual solvents and scavengers: what is looked for — what changed since Replied, post #6 · marked as the solution · Analytics › Impurities & related substances · 9 Feb 2026 · 32 likes Picking up post #3: that is the part I would want checked first. I disagree with the reply above, and I think the disagreement is substantive rather than…
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Converting between mg/mL and units per dose, both directions — the long version Replied, post #66 · Practice › Reconstitution · 22 Apr 2026 · 31 likes post #65 is right about the mechanism and I think understates the practical bit. Osmolarity and reconstitution: the osmolarity of the reconstituted solution affects…
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System suitability injections: if they failed, the run did not happen Replied, post #25 · Analytics › HPLC & UHPLC · 23 Aug 2025 · 31 likes On integration: where the baseline is drawn matters more than most people realise. On a clean chromatogram with well-resolved peaks the choice is inconsequential. On a…
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Forced degradation studies: designing one that is informative Replied, post #10 · Analytics › Method validation · 22 Feb 2026 · 30 likes Worth separating two things that post #6 runs together. Stability-indicating method: one that can separate a compound from its degradation products. Critical for assay…
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