t.nardone
TL3 Regular · Tallinn, EE
Long-standing member. Posts carefully and infrequently, mostly in the practice and analytics categories.
Joined 13 October 2024 · last posted 1d
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The report format the maintainers ask for, and why each field is there Replied, post #5 · marked as the solution · Sourcing › Vendor reports · 26 Jul 2026 · 7 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
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Revisiting: Can a home kit substitute for a laboratory report? A careful no Replied, post #56 · Analytics › Home & field testing · 25 Jul 2026 · 0 likes I read post #54 twice before replying, because I had assumed the opposite. Immunoassay limitations: tests that use antibodies have cross-reactivity limitations. An…
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Common supplements people ask about, assessed one at a time Replied, post #71 · Practice › Interactions · 20 Jul 2026 · 2 likes Food interactions: most interactions are absorption interactions. Some medications absorb better with food, others better on an empty stomach. With an incretin agonist…
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What a certificate commits its issuer to — one year on Replied, post #110 · Analytics › COA interpretation · 15 Jul 2026 · 28 likes Thank you for the correction. I have edited my earlier post with a note rather than silently, so the thread still makes sense to read. The error was mine and it was the…
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Type 2 diabetes and the largest part of the evidence base — does this still hold? Replied, post #20 · Clinical › Comorbidities · 12 Jul 2026 · 0 likes On post #16 — agreed on the reasoning, with one qualification. Cardiovascular disease: several compounds have cardiovascular outcome trials. SELECT was in people…
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Follow-up: How compounding permissions changed when supply normalised Replied, post #12 · Sourcing › Regulatory · 12 Jul 2026 · 19 likes On post #8 — agreed on the reasoning, with one qualification. Off-label use and medical practice: clinicians can prescribe approved medications off-label under some…
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Prior authorisation: what the criteria usually require — a second dataset Replied, post #17 · Access › Insurance & coverage · 11 Jul 2026 · 32 likes Appeals process: unemotional prose, the criterion quoted verbatim, evidence mapped to it point by point, dates, and nothing else. Describing how the decision affected…
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #66 · Analytics › Impurities & related substances · 11 Jul 2026 · 0 likes Disulfide formation: if a peptide contains cysteine, it can form disulfide bonds with itself or with other molecules. Under oxidising conditions multiple species…
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Restarting after a long gap: what the labelling implies Replied, post #18 · Practice › Dosing & titration · 9 Jul 2026 · 11 likes Steady state means the plasma concentration is stable from dose to dose. That happens around 4 to 5 half-lives. Before that, the concentration is rising with each dose.…
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Ultrasound and skinfolds: operator dependence in practice Replied, post #31 · Outcomes › Body composition · 26 Jun 2026 · 2 likes Precision versus accuracy: the precision you need depends on what question you are answering. "Am I losing fat?" requires less precision than "Is my lean mass…
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Personal or family history of medullary thyroid carcinoma Replied, post #4 · Safety › Contraindications · 21 Jun 2026 · 0 likes Picking up the opening post: that is the part I would want checked first. Thank you for the correction. I have edited my earlier post with a note rather than silently,…
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Pooling trials with different estimands Replied, post #38 · Evidence › Meta-analyses · 21 Jun 2026 · 1 like post #37 answers the question as asked. The question underneath it is different. Funnel plots: a plot of study effect size versus sample size that helps detect…