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Research Methods · subcategory

N-of-1 designs

Designing a personal experiment that could actually change your mind, including washouts and blinding.

14 topics713 posts4 solved Moderators: owen.brady, dr_okonkwo About this category

14 topics

TopicParticipantsRepliesViewsActivity
Pre-registering a personal experiment, seriously
Pre-registering a personal experiment, seriously — setting out what I have, and where I think it stops being reliable. Comparing STEP 4 ( JAMA , 2021) with SUSTAIN 6 ( N Engl J Med , 2016) and finding the…
PADAVSSJL+96 119 58k 14mo
An ABAB design with a data table and honest limitations — a second dataset
On the subject in the title: An ABAB design with a data table and honest limitations — a second dataset Working notes rather than a conclusion. Session topic: STEP 2 ( Lancet , 2021). Please read it before…
VELIGRAC+106 118 25k 4mo
Washout with a one-week half-life: the arithmetic
Washout with a one-week half-life: the arithmetic — setting out what I have, and where I think it stops being reliable. I have seen LEADER ( N Engl J Med , 2016) cited in support of a claim I do not think it…
SKTPBLCSF+90 96 44k 20mo
Pre-registering a personal experiment, seriously — a second dataset
Posting this under the heading it deserves: Pre-registering a personal experiment, seriously — a second dataset Everything below is what sits behind that. I have seen STEP 8 ( JAMA , 2022) cited in support of…
DMVKAFCVCL+60 66 35k 3mo
Designing a personal experiment that could change your mind — one year on
Designing a personal experiment that could change your mind — one year on — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it before…
TKNMPMBSMC+74 80 17k 2d
Blinding yourself: practical methods and their limits
On the subject in the title: Blinding yourself: practical methods and their limits Working notes rather than a conclusion. Comparing PIONEER 6 ( N Engl J Med , 2019) with STEP 4 ( JAMA , 2021) and finding the…
AZMBCRJNC+40 44 33k 5d
Coming back to: Why most self-reports here are not experiments, and that is fine
The question in the title: Why most self-reports here are not experiments, and that is fine I will give what I have already checked below so nobody repeats it. Comparing LEADER ( N Engl J Med , 2016) with…
MHAPNTKNK+56 62 11k 4mo
Washout with a one-week half-life: the arithmetic — does this still hold?
Washout with a one-week half-life: the arithmetic — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Comparing SURPASS-2 ( N Engl J Med , 2021)…
AFANABANNN+41 45 12k 1d
Second pass at: Designing a personal experiment that could change your mind
Second pass at: Designing a personal experiment that could change your mind Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURPASS-4 ( Lancet , 2021). Please…
JSJISTGBM+39 44 632 14mo
An ABAB design with a data table and honest limitations
An ABAB design with a data table and honest limitations Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURPASS-4 ( Lancet , 2021). Please read it before…
SSDSEF 2 45k 5mo
Why most self-reports here are not experiments, and that is fine
Why most self-reports here are not experiments, and that is fine — that is the question, and I have not found it answered plainly anywhere I have looked. I have seen SURPASS-2 ( N Engl J Med , 2021) cited in…
SBSKGF 2 46k 11mo
About the N-of-1 designs category
Designing a personal experiment that could actually change your mind, including washouts and blinding. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…
OBDOKAGRIA 4 22k 14h
Blinding yourself: practical methods and their limits — the long version
Blinding yourself: practical methods and their limits — the long version Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURMOUNT-OSA ( N Engl J Med , 2024)…
CTSDNGJEMD+7 11 1.8k 22h
Designing a personal experiment that could change your mind
Posting this under the heading it deserves: Designing a personal experiment that could change your mind Everything below is what sits behind that. Session topic: STEP 8 ( JAMA , 2022). Please read it before…
MGECFACHG+2 6 695 6mo