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Topics ordered by when they were created rather than by activity. This is where a question that nobody has answered yet is easiest to find — and answering one is the fastest route to a first solution badge.

1,535 topics · page 17 of 40

Topic	Participants	Replies	Views	Activity
Chain of custody for a sample you posted yourself — one year on Sourcing › Independent verification VendorInvestigate Janoshik Analytical blind sampling third-party testing Posting this under the heading it deserves: Chain of custody for a sample you posted yourself — one year on Everything below is what sits behind that. Structured report rather than an opinion, following the…	+28	32	50k	15h
[2026 update] What a purity-only report leaves out Sourcing › Independent verification PeptideMeter third-party testing Janoshik Analytical The question in the title: What a purity-only report leaves out I will give what I have already checked below so nobody repeats it. Structured report rather than an opinion, following the format the…	+97	103	5.2k	3mo
A plateau that disappeared when I changed how I measured — the long version Outcomes › Progress reports effect size data table long read A plateau that disappeared when I changed how I measured — the long version — setting out what I have, and where I think it stops being reliable. Longitudinal report with the method stated, because a number…	+49	54	9.4k	1mo
Muscle cramps: the ordinary causes before the exotic ones Practice › Side effects vomiting delayed gastric emptying nausea fatigue Closed Muscle cramps: the ordinary causes before the exotic ones Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+80	90	27k	6mo
A 10 mg vial reconstituted three different ways, compared Practice › Reconstitution bacteriostatic water worked example concentration maths Posting this under the heading it deserves: A 10 mg vial reconstituted three different ways, compared Everything below is what sits behind that. Practical question with the units stated, because I have seen…	+30	34	55k	17h
Validating a calculator against hand arithmetic Data & Tools › Calculators syringe units concentration maths worked example Solved Validating a calculator against hand arithmetic Writing it up because I had to work it out twice and would rather nobody else did. Working through the identity arithmetic and I would like it checked.…	+17	21	12k	3mo
About the N-of-1 designs category Research Methods › N-of-1 designs worked example confounding effect size Pinned Wiki Designing a personal experiment that could actually change your mind, including washouts and blinding. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	22k	14h
A parcel stationary at a customs facility for nine days — does this still hold? Sourcing › Logistics temperature excursion packaging cold chain customs Solved The question in the title: A parcel stationary at a customs facility for nine days — does this still hold? I will give what I have already checked below so nobody repeats it. A logistics question, since the…	+23	27	12k	1mo
Where to report an adverse event officially, by region Safety › Adverse events pancreatitis gallbladder vomiting hypoglycaemia Solved Where to report an adverse event officially, by region Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…		2	27k	1h
Restarting after a long gap: what the labelling implies — the long version Practice › Dosing & titration tirzepatide worked example dose reduction semaglutide Restarting after a long gap: what the labelling implies — the long version Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I…	+12	17	2.4k	2mo
Designing a personal experiment that could change your mind Research Methods › N-of-1 designs confounding worked example data table effect size Posting this under the heading it deserves: Designing a personal experiment that could change your mind Everything below is what sits behind that. Session topic: STEP 8 ( JAMA , 2022). Please read it before…	+2	6	695	6mo
A calculator that gives a right answer to the wrong question Data & Tools › Calculators concentration maths worked example site feedback syringe units Posting this under the heading it deserves: A calculator that gives a right answer to the wrong question Everything below is what sits behind that. I would like to understand what this number means before I…	+32	36	1.9k	17h
Second pass at: Which categories are strict and which are relaxed, honestly Start Here › Welcome guidelines beginner friendly trust levels onboarding Wiki On the subject in the title: Second pass at: Which categories are strict and which are relaxed, honestly Working notes rather than a conclusion. Question in the title. Context below, and I have tried to…	+93	99	36k	3d
Request: export my own posts Meta › Feature requests translation site feedback wiki post Posting this under the heading it deserves: Request: export my own posts Everything below is what sits behind that. Nominating something for promotion into the documentation commons. The topic in question…		2	57k	6mo
The SOUL trial and oral semaglutide cardiovascular outcomes Compounds › Oral incretins orforglipron oral semaglutide SOUL trial PIONEER programme Posting this under the heading it deserves: The SOUL trial and oral semaglutide cardiovascular outcomes Everything below is what sits behind that. Session topic: SCALE ( N Engl J Med , 2015). Please read it…		2	7.1k	9h
A partial dose because the pen emptied mid-injection Practice › Administration subcutaneous injection needle gauge & length injection site rotation missed dose Solved A partial dose because the pen emptied mid-injection Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+108	120	1.5k	7mo
Designing a personal experiment that could change your mind — one year on Research Methods › N-of-1 designs effect size data table worked example Designing a personal experiment that could change your mind — one year on — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it before…	+74	80	17k	2d
Managing an unplanned gap in supply Access › Shortages shortage formulary FDA compounding Managing an unplanned gap in supply — setting out what I have, and where I think it stops being reliable. A coverage question with the paperwork detail included, since that is what determines the answer.…	+105	110	5.1k	3mo
Second pass at: What to keep a record of at the point of payment Sourcing › Payments payments research use only documentation quality Second pass at: What to keep a record of at the point of payment — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better than…	+14	18	1.9k	4mo
Adducts: sodium, potassium, and the peak you did not expect — does this still hold? Analytics › Mass spectrometry high-resolution MS charge states mass error (ppm) MALDI-TOF Solved Asking directly, because I could not find a straight answer: Adducts: sodium, potassium, and the peak you did not expect — does this still hold? Posting the method first, because I know what the first three…	+113	119	1.7k	3mo
What a certificate commits its issuer to — one year on Analytics › COA interpretation reference standards certificate of analysis documentation quality batch & lot numbers Wiki What a certificate commits its issuer to — one year on — that is the question, and I have not found it answered plainly anywhere I have looked. A documentation question rather than an analytical one. I have a…	+107	117	6.5k	1d
Foaming during reconstitution and whether it matters — the long version Practice › Reconstitution reconstitution bacteriostatic water worked example concentration maths Foaming during reconstitution and whether it matters — the long version — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the…	+100	117	6k	3mo
Pharmacy supply in the UK and the questions you will be asked Regional › UK & Ireland personal import cost per milligram MHRA NHS On the subject in the title: Pharmacy supply in the UK and the questions you will be asked Working notes rather than a conclusion. A coverage question with the paperwork detail included, since that is what…	+95	105	1.3k	4mo
About the COA interpretation category Analytics › COA interpretation certificate of analysis documentation quality batch & lot numbers Pinned Wiki What a certificate of analysis commits its issuer to, which fields matter, and how to spot one that says almost nothing. This post is a community wiki: any member at trust level 3 or above can edit it, and…	+8	12	8.5k	2mo
Recording a dissent on a document rather than suppressing it Documentation › Doc review maintainership promoted to docs citation check Solved Recording a dissent on a document rather than suppressing it Writing it up because I had to work it out twice and would rather nobody else did. Process question about how this site works. I have read the…	+15	19	25k	1mo
Coming back to: A newcomer's list of things that confused me, and the fixes Start Here › Welcome guidelines onboarding trust levels beginner friendly Posting this under the heading it deserves: A newcomer's list of things that confused me, and the fixes Everything below is what sits behind that. Question in the title. Context below, and I have tried to…	+4	8	57k	23d
Non-inferiority margins: how they are chosen and how they are abused — a second dataset Evidence › Trials randomised trial discontinuation & dropout intention to treat estimand Non-inferiority margins: how they are chosen and how they are abused — a second dataset — setting out what I have, and where I think it stops being reliable. Comparing FLOW ( N Engl J Med , 2024) with…	+32	37	574	5mo
The most common factual error about semaglutide on the internet — what changed since Compounds › Semaglutide effect size randomised trial SELECT trial type 2 diabetes The most common factual error about semaglutide on the internet — what changed since — setting out what I have, and where I think it stops being reliable. Comparing SURMOUNT-2 ( Lancet , 2023) with STEP 1 ( N…	+42	46	1.7k	5mo
Tag proliferation and whether we should prune — what changed since Meta › Site feedback site feedback guidelines moderation Tag proliferation and whether we should prune — what changed since — setting out what I have, and where I think it stops being reliable. Nominating something for promotion into the documentation commons. The…	+5	9	709	5mo
Distinguishing expected GI effects from something that needs urgent attention Practice › Side effects nausea hair shedding vomiting delayed gastric emptying Closed Distinguishing expected GI effects from something that needs urgent attention Writing it up because I had to work it out twice and would rather nobody else did. Reporting something rather than asking about…	+88	101	32k	6mo